Serological and Clinical Comparison of Children and Adults with Anti-Endomysial Antibodies

Bonaci-Nikolic, Branka; Andrejević, Sladjana; Radlovic, Nedeljko; Davidovic, Ivana; Sofronic, Ljiljana; Špuran, Milan; Micev, Marjan; Nikolić, Miloš

doi:10.1007/s10875-006-9062-y

Cited by 10 publications

(9 citation statements)

References 42 publications

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“…Treatment with a gluten-free diet contributed to clinical improvement in one DM patient, but not in the two IBM patients. This finding is consistent with other data indicating that subclinical CD may be more common than previously thought; the prevalence might be as high as 1% [10]. …”

Section: Discussionsupporting

confidence: 93%

Autoantibody profiles in two patients with non-autoimmune muscle disease implicate a role for gliadin autoreactivity

Olsen¹,

Prather²,

Li³

et al. 2010

Neuromuscular Disorders

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The objective of this case study was to characterize autoreactivity in two patients with non-autoimmune forms of muscle disease who had positivity for antinuclear antibodies (ANA) and Ro (SSA) autoantibodies. Serum samples from these two patients were applied to an autoantigen protein array with more than 70 specificities and were compared to samples from healthy controls and patients with systemic lupus erythematosus. Both myopathy patients had high levels of gliadin autoreactivity in serum and one patient had an overall autoantibody profile with lupus-like features. The findings suggest that some disorders of muscle that are considered nonautoimmune, may in fact have autoimmune features. Further examination of the role of subclinical gluten autoreactivity in the pathogenesis of myopathy syndromes has the potential to suggest improved approaches to diagnosis and treatment of these conditions.

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Section: Discussionsupporting

confidence: 93%

Autoantibody profiles in two patients with non-autoimmune muscle disease implicate a role for gliadin autoreactivity

Olsen¹,

Prather²,

Li³

et al. 2010

Neuromuscular Disorders

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“…These results corroborate with the higher predisposition of female including celiac relatives to the development of different AID (8,9) . The positivity of AAB between relatives > 60 years (17.65%) demonstrated a trend to the significance (P = 0.083) in relation to other individuals, suggesting that the persistent consumption of gluten can represent a trigger to these positivity in genetically susceptible individuals, such as celiac relatives.…”

Section: Discussionsupporting

confidence: 86%

Autoantibodies in relatives of celiac disease patients: a follow-up of 6-10 years

Nass

Kotze

Nisihara

et al. 2012

Arq. Gastroenterol.

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-Context -Autoimmune diseases are 3 to 10 times more frequently in patients with celiac disease and their relatives than in the general population. Objective -To investigate a broad spectrum of autoantibodies in celiac disease relatives from Southern Brazil, in a serological follow-up of 6-10 years, aiming to associate with other autoimmune diseases, degree of parentage, demographic and clinical data. Methods -Serum samples of 233 relatives were analyzed in two different phases: n = 186 in phase I (1997)(1998)(1999)(2000) and n = 138 (being 91 = follow-up group and 47 = newly tested) in phase II (2006II ( -2007. As controls, 100 unrelated individuals were evaluated. Autoantibodies to smooth muscle, mitochondrial, liver-kidney microssome, parietal cell and thyroid microssome were tested by indirect immunofluorescence. Results -A significant increase of autoantibodies, in both phases, was observed in the relatives when compared to the non-relatives (P = 0.0064), specifically to anti-thyroid microssome and anti-parietal cell. In both phases, the female/male proportion of autoantibodies was of 4:1 to 3:1 (P≤0.041). The frequency of autoantibodies amongst 1st and 2nd degree relatives was 11.8% and 9.68% in phase I and 4% and 6.67% in phase II. Conclusion -Celiac disease relatives presented other autoantibodies and serological screening is a useful instrument for identifying autoimmune diseases along the years.

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“…However, the presence of associated pathologies in adults seems to be more frequent and may have an autoimmune origin like CD. Autoimmune disorders such as autoimmune thyroiditis, type Ⅰ diabetes, Sjögren's syndrome or dermatitis herpetiformis have been linked to CD [14,15] . Even though malnutrition is a frequent manifestation in CD, mainly in adults, excessive weight or obesity may also be present at diagnosis.…”

Section: Symptomatologymentioning

confidence: 99%

Age-related differences in celiac disease: Specific characteristics of adult presentation

Vivas

Vaquero

Rodríguez-Martín

et al. 2015

WJGPT

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Celiac disease may appear both in early childhood and in elderly subjects. Current knowledge of the disease has revealed some differences associated to the age of presentation. Furthermore, monitoring and prognosis of celiac subjects can vary depending on the pediatric or adult stage. The main objective of this review is to provide guidance for the adult diagnostic and follow-up processes, which must be tailored specifically for adults and be different from pediatric patients.

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Serological and Clinical Comparison of Children and Adults with Anti-Endomysial Antibodies

Cited by 10 publications

References 42 publications

Autoantibody profiles in two patients with non-autoimmune muscle disease implicate a role for gliadin autoreactivity

Autoantibody profiles in two patients with non-autoimmune muscle disease implicate a role for gliadin autoreactivity

Autoantibodies in relatives of celiac disease patients: a follow-up of 6-10 years

Age-related differences in celiac disease: Specific characteristics of adult presentation

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