Serological classification of infectious pancreatic necrosis (IPN) virus and other aquatic birnaviruses

Hill, Barry; Way, K.

doi:10.1016/0959-8030(95)00011-9

Cited by 155 publications

(156 citation statements)

References 36 publications

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“…Aquabirnaviruses were initially grouped into 10 serotypes (Hill & Way, 1995), with a certain relationship to the geographical origin. The genotyping of these viruses by Blake et al (2001) also demonstrated some correlation between serotyping and the geographical origin of the strains.…”

Section: Introductionmentioning

confidence: 99%

Aquabirnavirus polyploidy: a new strategy to modulate virulence?

Lago

Rodrı́guez

Bandı́n

et al. 2016

Journal of General Virology

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One of the main research issues regarding infectious pancreatic necrosis virus (IPNV) is its virulence mechanisms. The basis for understanding the molecular virulence determinants of this virus was established over the last decade when it was demonstrated that certain amino acid domains in the VP2 and VP2-NS inter-region determined the level of virulence of IPNV. However, certain variability was still inexplicable and therefore other factors may also be involved. To this end, it was demonstrated recently that infectious bursal disease virus (IBDV), a virus in a different genus of the same family as IPNV, can package more than two dsRNA segments, and that polyploidy may be associated with virulence. In the present report, we analysed the viral fractions obtained after gradient centrifugation to demonstrate that IPNV virions can also package more than two segments, thus indicating that polyploidy is a common birnavirus trait. The differential replication ex vivo and virulence in vivo additionally suggested that such a characteristic is involved in the modulation of virus infectivity. However, although the ex vivo results clearly demonstrated that the replication capacity was enhanced as the viral ploidy increased, the in vivo results could not strongly support a direct relationship between ploidy and virulence to the host, thus suggesting that other virulence determinants are also involved.

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Section: Introductionmentioning

confidence: 99%

Aquabirnavirus polyploidy: a new strategy to modulate virulence?

Lago

Rodrı́guez

Bandı́n

et al. 2016

Journal of General Virology

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“…IPNV causes high mortality in young salmonid fish but in older salmonid fish and various non-salmonid fishes, it usually causes subclinical or persistent infection1, 5,6). MABV is of marine origin which causes mortality to fry and finger lings of many marine fishes such as yellowtail Seriola quinqueradiata, Japanese flounder Paralichthys olivaceus and red sea bream Pagrus major3,7, and shellfish such as Agemaki (Jack Knife Clam) Sinonovacura constricta8) and Japanese pearl oyster Pinctada fucata9).…”

Section: Pathogenicity Histopathologymentioning

confidence: 99%

Pathogenicity of Marine Birnavirus against Ayu Plecoglossus altivelis.

Jung¹,

Oh²,

Kawai³

2001

Fish Pathol.

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ABSTRACT--Pathogenicity of a marine birnavirus ) isolated from diseased ayu Plecoglossus altivelis was investigated.Cumulative mortalities in the intrap eritoneally injected groups of ayu in two weeks were 70% (dose 105.4 TCID50/fish)-71%(105.8 TCID50/fish) in dupli cated experiments.Histologically, the naturally and ex perimentally infected fish showed brain congestion and pancreatic necrosis. From the symptoms of body defor mity and congestion in the brain, it was thought that AY-98 is similar to viral deformity virus, the birnavirus iso lated from yellow tail Seriala quinqueradiata with defor mity.

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“…IPNV causes infectious pancreatic necrosis, an acute and serious disease in juvenile salmonid fish worldwide (Hill and Way, 1995) Birnaviruses possess a bi-segmented, double-stranded RNA genome contained within a medium-sized, unenveloped, icosahedral capsid. The protein products of four unrelated major genes undergo various post-translational cleavage processes to generate three to five different structural proteins (Dobos, 1995).…”

Section: Introductionmentioning

confidence: 99%