Serological cross-reactions between Bartonella quintana, Bartonella henselae, and Coxiella burnetii

Scola, Bernard La; Raoult, Didier

doi:10.1128/jcm.34.9.2270-2274.1996

Cited by 273 publications

(96 citation statements)

References 34 publications

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“…22 A low level of cross-reaction with C burnetii also has been reported in Bartonella infections. 27 However, none of the dogs that had a high serum antibody titer to Bartonella were seroreactive for C burnetii in this study. Sensitivity could not be determined because the affected valves of all dogs with IE in the current study were not available for PCR analysis of Bartonella.…”

Section: Discussioncontrasting

confidence: 53%

A Prospective Study of Canine Infective Endocarditis in Northern California (1999–2001): Emergence of Bartonella as a Prevalent Etiologic Agent

MacDonald¹,

Chomel²,

Kittleson³

et al. 2004

J Vet Int Med

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A prospective study was performed (June 1999 to May 2001) to determine the incidence of infective endocarditis (IE) due to Bartonella in dogs in northern California and to compare these patients with other dogs with IE. IE was diagnosed antemortem based on clinical signs and echocardiography in 18 dogs. The etiologic agent was Bartonella sp. in 5 dogs (28%) and was diagnosed by high seroreactivity to Bartonella (titer > 1:512; range, 1:1,024-1:4,096); and confirmed postmortem by positive polymerase chain reaction (PCR)-restriction fragment length polymorphism (RFLP) from the infected valve and partial DNA sequencing of the citrate synthase gene (glt A). Conventional bacteria were causative agents in 7 dogs (39%). An etiologic agent was not identified in 6 dogs (33%). Bartonella vinsonii berkhoffii (n = 3), B clarridgeiae (n = 1), and a B clarridgeiae-like organism (n = 1) were identified. Blood culture was positive only for the IE case due to B clarridgeiae. All dogs with IE due to Bartonella were also seroreactive to Anaplasma phagocytophilum. All dogs with IE due to Bartonella had lesions only on the aortic valve. Of the cases of IE not due to Bartonella, 31% involved the aortic valve, 61% the mitral valve, and 8% both valves. Dogs with mitral valve IE lived longer than all dogs with aortic valve IE (P = .004) and dogs with IE of the aortic valve due to Bartonella (P = .002). In conclusion, Bartonella is a common cause of IE in dogs of northern California. A high Bartonella serologic titer (> 1:512) is useful antemortem to diagnose aortic valve IE due to Bartonella.

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Section: Discussioncontrasting

confidence: 53%

A Prospective Study of Canine Infective Endocarditis in Northern California (1999–2001): Emergence of Bartonella as a Prevalent Etiologic Agent

MacDonald¹,

Chomel²,

Kittleson³

et al. 2004

J Vet Int Med

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“…However, care should be taken when interpreting positive Q fever serology, especially lowlevel immunoglobulin M, as cross-reactions are common with organisms such as Legionella and Bartonella species. 11,12…”

Section: Discussionmentioning

confidence: 99%

Two rare severe and fulminant presentations of Q fever in patients with minimal risk factors for this disease

Munckhof

Runnegar

Gray

et al. 2007

Internal Medicine Journal

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“…The most troublesome aspects of serology in this sense are the cross-reactivity with Chlamydia, Legionella and Bartonella spp. 9,12,13 all causative agents of very close clinical syndromes. Other rickettsial agents are also prone in inducing cross-reactivity with C. burnetii usually in lower titers 4,5,7,12 as observed in some cases here reported.…”

Section: Discussionmentioning

confidence: 99%

Questing one Brazilian query: reporting 16 cases of Q fever from Minas Gerais, Brazil

Costa

Brigatte²,

Greco

2006

Rev. Inst. Med. trop. S. Paulo

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Q fever has been considered non-existing in Brazil where reports of clinical cases still cannot be found. This case-series of 16 patients is a result of a systematic search for such illness by means of clinical and serologic criteria. Serologic testing was performed by the indirect microimmunofluorescence technique using phase I/II C. burnetii antigens. Influenza-like syndrome was the most frequent clinical form (eight cases--50%), followed by pneumonia, FUO (fever of unknown origin), mono-like syndrome (two cases--12.5% each), lymphadenitis (one case--6.3%) and spondylodiscitis associated with osteomyelitis (one case--6.3%). The ages varied from four to 67 years old with a median of 43.5. All but one patient had positive serologic tests for phase II IgG whether or not associated with IgM positivity compatible with acute infection. One patient had both phase I and phase II IgG antibodies compatible with chronic Q fever. Seroconvertion was detected in 10 patients. Despite the known limitations of serologic diagnosis, the cases here reported should encourage Brazilian doctors to include Q fever as an indigenous cause of febrile illness.

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Serological cross-reactions between Bartonella quintana, Bartonella henselae, and Coxiella burnetii

Cited by 273 publications

References 34 publications

A Prospective Study of Canine Infective Endocarditis in Northern California (1999–2001): Emergence of Bartonella as a Prevalent Etiologic Agent

A Prospective Study of Canine Infective Endocarditis in Northern California (1999–2001): Emergence of Bartonella as a Prevalent Etiologic Agent

Two rare severe and fulminant presentations of Q fever in patients with minimal risk factors for this disease

Questing one Brazilian query: reporting 16 cases of Q fever from Minas Gerais, Brazil

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