Serological evidence of hepatitis E virus infection in dromedary camels in Ethiopia

Li, Tiancheng; Yoshizaki, Sayaka; Zhou, Xianfeng; Sentsui, Hiroshi; Shirato, Kunio; Matsuyama, Shutoku; Melaku, Simenew Keskes; Boldbaatar, Bazartseren; Takeda, Naokazu; Wakita, Takaji

doi:10.1016/j.jviromet.2017.04.008

Cited by 21 publications

(32 citation statements)

References 15 publications

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“…HEV prevalence among dromedary camels, has been studied in the past and following literature review we realise that our finding (68.6%) is higher than the 22.4% seroprevalence rates reported in Ethiopia [31], but similar to the 62.9% seropositivity among dromedary camels recently reported in Egypt, a nearby country [32]. Together, these results suggest that the 1-humped camels in our region are highly seropositive for HEV.…”

Section: Discussionsupporting

confidence: 79%

Seroprevalence of hepatitis E virus in dromedary camels, Bedouins, Muslim Arabs and Jews in Israel, 2009–2017

et al. 2019

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Hepatitis E virus (HEV) is an emerging cause of viral hepatitis worldwide. Recently, HEV-7 has been shown to infect camels and humans. We studied HEV seroprevalence in dromedary camels and among Bedouins, Arabs (Muslims, none-Bedouins) and Jews and assessed factors associated with anti-HEV seropositivity. Serum samples from dromedary camels (n = 86) were used to determine camel anti-HEV IgG and HEV RNA positivity. Human samples collected between 2009 and 2016 from >20 years old Bedouins (n = 305), non-Bedouin Arabs (n = 320) and Jews (n = 195), were randomly selected using an age-stratified sampling design. Human HEV IgG levels were determined using Wantai IgG ELISA assay. Of the samples obtained from camels, 68.6% were anti-HEV positive. Among the human populations, Bedouins and non-Bedouin Arabs had a significantly higher prevalence of HEV antibodies (21.6% and 15.0%, respectively) compared with the Jewish population (3.1%). Seropositivity increased significantly with age in all human populations, reaching 47.6% and 34.8% among ⩾40 years old, in Bedouins and non-Bedouin Arabs, respectively. The high seropositivity in camels and in ⩾40 years old Bedouins and non-Bedouin Arabs suggests that HEV is endemic in Israel. The low HEV seroprevalence in Jews could be attributed to higher socio-economic status.

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Section: Discussionsupporting

confidence: 79%

Seroprevalence of hepatitis E virus in dromedary camels, Bedouins, Muslim Arabs and Jews in Israel, 2009–2017

et al. 2019

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“…The seroprevalence of HEV antibodies recorded for dromedaries (8.11%) in our study, suggest that DcHEV infection is common among dromedary camels in the Sahelian zone of West Africa. The prevalence observed in our study is lower than that recorded in East African cost: Ethiopia 22.4% in 2013 (using In-house test) [13], in Somalia 40% in 2016 (using HEV-ELISA-EU-ROIMMUN) [9], 15% in Soudan in 2016 (using HEV-ELISA-EU-ROIMMUN) [9], 62.9% in Egypt (using HEV-ELISA-EU-ROIMMUN) and 31.4% in Kenya in 2016 (using HEV-ELISA-EU-ROIMMUN) [9]. In Middle Est area, seroprevalence of 37.1% in United Arab Emirates [9] and 60.0% in Pakistan [9] were recorded.…”

Section: Seroprevalence Of Hevcontrasting

confidence: 79%

“…DcHEV has the same serotype as that of G1, G3 and G4 HEV [12,13], for this purpose, sera of dromedaries were tested for the detection of HEV antibodies by multi-species ELISA kit (ID Screen® Hepatitis E Indirect Multi-species, Paris, France). This commercially available double antigen sandwich ELISA (das-ELISA) test developed strictly for veterinary use, is indirect ELISA for the detection of anti-Hepatitis E total antibodies in serum and plasma from swine and other animal species using a recombinant genotype 3 capsid antigen and a multispecies conjugate.…”

Section: Detection Of Total Antibodies Against Hev In Serummentioning

confidence: 99%

Serological Evidence of Hepatitis E Virus in Dromedary Camels in the Sahelian Zone of West Africa

Ouoba¹,

Ouedraogo²,

Traoré³

et al. 2019

JAMB

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Aim: This study was undertaken to determine the sero-epidemiological information and associated risk factors, of Hepatitis E virus (HEV) among dromedaries in Sub-sahelian region. Study Design: Cross sectional epidemiological survey. Place and Duration: The study was carried out in three countries of West Africa (Burkina Faso, Mali and Niger), over a two month period from February to March 2015. Methodology: A total of 133 serum samples collected from dromedaries (Camelus dromedarius) were examined for the detection of anti-DcHEV total antibody by a mammals targeted ELISA kit (ID vet, France), using a multispecies conjugate. Results: Eleven of the 133 (8.33%; 95%CI [3.6 – 13.0]) dromedaries were positive for anti-DcHEV antibodies. Positive cases had a random geographic distribution (p˃0.05) and all seropositive dromedaries were in close contact with other domestic animals. Conclusion: This study highlight the circulation of HEV in West African mammals and specifically in dromedaries. This is the first study reporting HEV circulation in dromedaries in West Africa. Further studies is needed to identify the HEV genotype involved in the dromedary camel infection, and evaluation of potential transmission to dromedary’s care keepers.

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“…The seroprevalence of DcHEV infection has not been well studied, even in areas where camels are most frequently available for use in transportation and for meat and milk, due to the lack of an accurate method for detecting anti-DcHEV antibodies. A previous study showed that an enzyme-linked immunosorbent assay (ELISA) using virus-like particles of DcHEV (DcHEV-LPs) could detect anti-DcHEV IgG and IgM [31] in camels and was utilized for investigating the prevalence of anti-DcHEV in camels from Ethiopia [32].…”

Section: Introductionmentioning

confidence: 99%

Seroprevalence of Dromedary Camel HEV in Domestic and Imported Camels from Saudi Arabia

El‐Kafrawy

Hassan

El-Daly

et al. 2020

Viruses

Self Cite

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Hepatitis E Virus (HEV) imposes a major health concern in areas with very poor sanitation in Africa and Asia. The pathogen is transmitted mainly through ingesting contaminated water or food, coming into contact with affected people, and blood transfusions. Very few reports including old reports are available on the prevalence of HEV in Saudi Arabia in humans and no reports exist on HEV prevalence in camels. Dromedary camel trade and farming are increasing in Saudi Arabia with importation occurring unidirectionally from Africa to Saudi Arabia. DcHEV transmission to humans has been reported in one case from the United Arab Emeritus (UAE). This instigated us to perform this investigation of the seroprevalence of HEV in imported and domestic camels in Saudi Arabia. Serum samples were collected from imported and domestic camels. DcHEV-Abs were detected in collected sera using ELISA. The prevalence of DcHEV in the collected samples was 23.1% with slightly lower prevalence in imported camels than domestic camels (22.4% vs. 25.4%, p value = 0.3). Gender was significantly associated with the prevalence of HEV in the collected camels (p value = 0.015) where males (31.6%) were more infected than females (13.4%). This study is the first study to investigate the prevalence of HEV in dromedary camels from Saudi Arabia. The high seroprevalence of DcHEV in dromedaries might indicate their role as a zoonotic reservoir for viral infection to humans. Future HEV seroprevalence studies in humans are needed to investigate the role of DcHEV in the Saudi human population.

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Serological evidence of hepatitis E virus infection in dromedary camels in Ethiopia

Cited by 21 publications

References 15 publications

Seroprevalence of hepatitis E virus in dromedary camels, Bedouins, Muslim Arabs and Jews in Israel, 2009–2017

Seroprevalence of hepatitis E virus in dromedary camels, Bedouins, Muslim Arabs and Jews in Israel, 2009–2017

Serological Evidence of Hepatitis E Virus in Dromedary Camels in the Sahelian Zone of West Africa

Seroprevalence of Dromedary Camel HEV in Domestic and Imported Camels from Saudi Arabia

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