SEROLOGICAL EVIDENCE OF INFECTION WITH <i>HELICOBACTER PYLORI</i> MAY PREDICT GASTROINTESTINAL INTOLERANCE TO NON-STEROIDAL ANTI-INFLAMMATORY DRUG (NSAID) TREATMENT IN RHEUMATOID ARTHRITIS

Jones, Sian; Clague, R B; Eldridge, J.; Jones, D. M.

doi:10.1093/rheumatology/30.1.16

Cited by 57 publications

(4 citation statements)

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“…Endoscopic evidence is flawed in patients undergoing endoscopy for clinical reasons since H. pylori infection is associated with NSAID‐induced dyspepsia, 20 , 25 , 32 –34 making it likely that H. pylori positive individuals would be endoscoped more readily than H. pylori negative individuals 25 and increasing the chances that an incidental ulcer would be discovered by chance. In large studies where patients taking NSAIDs (without ulcer prophylaxis) were endoscoped involuntarily to a set protocol, the incidence of ulceration was almost exactly the same in those who were H. pylori positive or negative 35 .…”

Section: Nsaid and H Pylori—the Endoscopic Evidencementioning

confidence: 99%

Helicobacter pylori, NSAIDs and cognitive dissonance

Hawkey¹

1999

Aliment Pharmacol Ther

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Helicobacter pylori and non‐steroidal anti‐inflammatory drugs (NSAIDs) each cause peptic ulcers but by different mechanisms. As a result, the effect of both of these risk factors together is not a synergistic enhancement of injury, ulceration or rates of complications. Indeed, there are circumstances under which patients infected with H. pylori are less prone to NSAID‐induced ulcers than those who are not infected or who have undergone eradication treatment. This may be because of opposite effects on gastric mucosal prostaglandin synthesis or for other reasons. Reluctance to accept that there may be specific circumstances where H. pylori is beneficial may arise because of the psychological process of cognitive dissonance.

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Section: Nsaid and H Pylori—the Endoscopic Evidencementioning

confidence: 99%

Helicobacter pylori, NSAIDs and cognitive dissonance

Hawkey¹

1999

Aliment Pharmacol Ther

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“…These results could imply that the presence of H. pylori in NERD prevents the development of gastric mucosal erosion, as shown in ERD through its acid regulation [ 28 ]. In addition, reflux symptoms observed in NERD patients could overlap with other diseases such as IBD and heartburn related to H. pylori infection [ 29 , 30 ]. Our study results also suggested evaluating H. pylori infection in patients with reflux symptoms.…”

Section: Discussionmentioning

confidence: 99%

Analysis of gastric microbiota and Helicobacter pylori infection in gastroesophageal reflux disease

et al. 2022

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Background We evaluated the microbiota in the stomach of Gastroesophageal Reflux Disease (GERD) patients. We compared Erosive Reflux Disease (ERD) to gastritis and Non-erosive Reflux Disease (NERD) subjects by 16S rRNA approach on gastric biopsy specimens. A total of 197 subjects were included consisting of gastritis (68; 34.52%), ERD (55; 27.92%), and NERD (74; 37.56%). After quality filtering, 187 samples were included for OTU analysis using Qiime2. Results We observed a significant difference in alpha diversity (Shannon and Simpson indexes were P = 0.0016 and P = 0.017, respectively). A significant decrease in alpha diversity index was observed in NERD with Helicobacter pylori (H. pylori)-positive subjects than in gastritis (Simpson index P = 0.022; Shannon index P = 0.029), indicating a significant influence of H. pylori on the diversity in the stomach despite the diseases. In H. pylori-negative samples, alpha diversity measurement by the abundance coverage estimates (ACE) and Fisher Test revealed that ERD had significantly lower richness than gastritis and NERD groups (P = 0.00012 and P = 0.00043, respectively). Anaerobacillus sp. could only be found in ERD patients by LEFse analysis. Conclusions The presence of ERD could alter microbiome diversity. A negative correlation between H. pylori and ERD is shown in this microbiome study but not in NERD.

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“…Moreover, they found that H. pylori seropositive RA patients who also had a positive cytotoxinassociated gene A protein (CagA) also scored significantly higher on disease activity score 28 (DAS28) and visual analogue scale (VAS) than their CagA negative counterparts [23]. Jones et al estimated the presence of H. pylori infection to be 43-68% among RA patients, [24] which is consistent with the findings of the study performed by Ebrahimi et al [23]. Zentilin et al confirmed the results of the aforementioned study on the higher rate of ESR and CRP in RA patients with H. pylori infection in comparison to those who are not infected by H. pylori [25].…”

Section: Funding_______________________________mentioning

confidence: 99%

Comparison of serum and synovial fluid markers of Herpes simplex virus and Helicobacter pylori infection between rheumatoid arthritis and osteoarthritis patients: A Retrospective Case-Control Study

et al. 2021

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43Recently, several infectious agents including Epstein-Barr virus and Escherichia coli have been suggested as possible contributing factors to the pathogenesis of rheumatoid arthritis (RA). This study was designed to compare serum and synovial fluid markers of herpes simplex virus (HSV) and Helicobacter pylori of RA and osteoarthritis (OA) patients. This comparative study was conducted on two hundred OA and RA patients who referred to the Rheumatic Diseases Research Center (RDRC) affiliated with Mashhad University of Medical Sciences, Mashhad, Iran, from March 2015 to 2016. Synovial fluid was obtained from all individuals. Two years later, participants attended a follow-up session to collect blood samples for serum markers of these two infectious agents. Twenty-five patients (96.15%) in the RA group and 23 individuals (92%) in the OA group had positive serum IgG antibodies for HSV. As for Helicobacter pylori, 13 individuals (50%) in RA and 12 individuals (48%) had positive serum IgG antibodies (p value = 0.66). In addition, 9 (34.6%) and 8 (30.8%) in the RA group and 10 (40%) and 3 (12%) in the OA group had positive serum IgA and IgM antibodies for Helicobacter pylori, respectively (p value = 0.89 and p value = 0.13, respectively). Collected fluid samples were negative for both Helicobacter pylori and HSV1 and 2 DNA particles in all individuals. Based on the results of the current study, there is no difference between RA and OA patients in terms of Herpes simplex virus and Helicobacter pylori infection.

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SEROLOGICAL EVIDENCE OF INFECTION WITH HELICOBACTER PYLORI MAY PREDICT GASTROINTESTINAL INTOLERANCE TO NON-STEROIDAL ANTI-INFLAMMATORY DRUG (NSAID) TREATMENT IN RHEUMATOID ARTHRITIS

Cited by 57 publications

References 0 publications

Helicobacter pylori, NSAIDs and cognitive dissonance

Helicobacter pylori, NSAIDs and cognitive dissonance

Analysis of gastric microbiota and Helicobacter pylori infection in gastroesophageal reflux disease

Comparison of serum and synovial fluid markers of Herpes simplex virus and Helicobacter pylori infection between rheumatoid arthritis and osteoarthritis patients: A Retrospective Case-Control Study

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