Serological identification of past and recent <scp>SARS‐CoV</scp>‐2 infection through antibody screening in Luanda, Angola

Sebastião, Cruz S.; Galangue, Manuela; Gaston, Celestina; Van‐Dunen, Rui; Jandondo, Domingos; Neto, Zoraima; Vasconcelos, Jocelyne Neto de; Morais, José

doi:10.1002/hsr2.280

Cited by 6 publications

(8 citation statements)

References 10 publications

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“…The rate of SARS-CoV-2 infection increased from 0.3% in parturients under 20 to 0.4% in parturients aged 20 years and over (Table 1). These results are similar to those observed by a study carried out by our research team in the general population of Luanda, where we observed that the rate, as well as the risk of SARS-CoV-2 infection, increased with increasing age [16,17], leading to the belief that these are people who are in the active stage of life and who perform work or other activities that expose them more frequently to the virus. Our results also corroborate those of previous studies in terms of the decrease in infection (0.6% to 0.1%, p = 0.012) and risk of infection (OR: 0.18, p = 0.025) in non-urbanized to urbanized areas, respectively (Table 1).…”

Section: Discussionsupporting

confidence: 91%

Prevalence and Risk Factors of SARS-CoV-2 Infection among Parturients and Newborns from Luanda, Angola

et al. 2021

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SARS-CoV-2 emerged in China in December 2019, creating a massive public health concern. Although previous studies have identified SARS-CoV-2 in pregnant women, the possibility of transmission to newborns remains uncertain. Herein, we investigated SARS-CoV-2 infection and risk factors among parturients and newborns. This was a cross-sectional study carried out with 3633 parturients from Luanda, Angola, between January and April 2021, with an age ranging from 13 to 48 years. SARS-CoV-2 infection of the parturients was further confirmed with RT-PCR after COVID-19 Ag Rapid Testing. About 0.4% of parturients tested positive on the day of delivery. Surprisingly, parturients from urbanized areas (OR: 0.18, p = 0.025) had a low chance of infection. None of the newborns tested positive in the first 24 h after birth, while one (9.1%, 1/10) of the newborns tested positive with pharyngeal swabs seven days after birth. However, whether the case was due to vertical transmission from mother to child remains to be confirmed. The mother’s residence, education level, antenatal follow-up, and delivery category were related to SARS-CoV-2 transmission (p < 0.05). Our findings showed a relatively low SARS-CoV-2 infection from parturients to newborns, regardless of the severity of the maternal disease. Furthermore, these findings are an early assessment of COVID-19 cases in late pregnancy, which could indicate the need for intensive management of SARS-CoV-2 infection among parturients in Angola. Further studies are needed on the consequences of SARS-CoV-2 among pregnant women and neonates from Angola.

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Section: Discussionsupporting

confidence: 91%

Prevalence and Risk Factors of SARS-CoV-2 Infection among Parturients and Newborns from Luanda, Angola

et al. 2021

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“…Similar to our results, other studies carried out among COVID-19 patients from China, have reported several risk factors, such as older age, male gender, and the presence of underlying chronic comorbidities with SARS-CoV-2 positivity and/or unfavorable clinical outcome among COVID-19 patients. [18,19] Also, in line with prior studies carried out by our research team in Angola [20,21], we observed an increase in SARS-CoV-2 infection rate with increasing age, men were the most affected, and the urbanized areas with the highest rate of infection (Table 1).…”

Section: Discussionsupporting

confidence: 89%

The impact of the ABO/Rh blood group on susceptibility and severity among COVID-19 patients in Luanda, Angola

Sebastião¹,

Teixeira

Luisa³

et al. 2022

Preprint

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SARS-CoV-2 is a public health concern worldwide. Identification of biological factors that could influence transmission and worsen the disease has been the subject of extensive investigation. Herein, we investigate the impact of the ABO/Rh blood group on susceptibility and severity among COVID-19 patients in Luanda, Angola. This was a multicentric cohort study conducted with 101 COVID-19 patients. Chi-square and logistic regression were calculated to check factors related to the worsening of the disease and deemed significant when p<0.05. Blood type O (51.5%) and Rh-positive (93.1%) were the most frequent. Patients from blood type O had a high risk to severe disease [OR: 1.33 (95% CI: 0.42 - 4.18), p=0.630] and hospitalization [OR: 2.59 (95% CI: 0.84 - 8.00), p=0.099]. Also, Rh-positive blood type presented a high risk for severe disease (OR: 10.6, p=0.007) and hospitalization (OR: 6.04, p=0.026). We find a high susceptibility, severity, hospitalization, and mortality, respectively, among blood group O and Rh-positive patients, while blood group AB presented a low susceptibility, severity, hospitalization, and mortality, respectively. Our findings add to the body of evidence suggesting that ABO/Rh blood groups play an important role in the course of SARS-CoV-2 infection.

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“…These measures also showed positive results in the spread of SARS-CoV-2 infection in low prevalence among the Angolan population residing in different settings, as reported by our research team in previous studies. [13][14][15][16][17] A cohort study carried out in Italy, found that about 88% of the population was fully vaccinated which was slightly low compared with the 98% rate of vaccinates observed in our study (Table 1). Also, our study presents about 10% of the unvaccinated population and there were mainly non-healthcare professionals,…”

Section: Discussioncontrasting

confidence: 66%

Immune profile of healthcare professionals six months after vaccination or exposure to SARS‐CoV‐2 in Angola

Sebastião

Sacomboio

Francisco³

et al. 2023

Health Science Reports

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Background and Aims Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection is a public health concern. Until 2021, more than 2 million cumulative deaths were reported worldwide. Herein, we investigated the immune profile of healthcare professionals 6 months after vaccination or exposure to SARS‐CoV‐2 in Angola. Methods This was a prospective study conducted with 1068 Angolan healthcare professionals between August and December 2021. Participants were screened for the presence of IgG and IgM against SARS‐CoV‐2. Results About 9.6% and 98.2% of the participants had prior exposure to SARS‐CoV‐2 or vaccination against it, respectively. Participants aged between 20 and 40 years (11.2%), female (12.4%), with higher educational level (12.8%), from Luanda (60.3%), and nonhealthcare professionals (8.1%) were the most affected by the SARS‐CoV‐2. Gender, education, and local residence were related to SARS‐CoV‐2 exposure ( p < 0.05). About 7.3% and 98% of the exposed population developed IgM and IgG after 3 months of exposure, respectively. The AstraZeneca vaccine was the most used, followed by the Jonhson & Johnson and Sputinik. Almost all (98%) participants vaccinated with AstraZeneca had immunity >3 months. Individuals who received only the first dose regardless of the type of vaccine had a higher immunity duration (>3 months) than those who received two doses. For individuals who received the Sputnik and Johnson, the average immunity was lower (<3 months), especially among those who were older (over 40 years old) and exposed to SARS‐CoV‐2. Conclusion We observed a high adherence rate to vaccination and a long immunity duration. The immunity duration depended on the type of vaccine. Further studies on the immunity profile in the population exposed to SARS‐CoV‐2 must be carried out in the general population from Angola to assess antibody‐waning periods.

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Serological identification of past and recent SARS‐CoV‐2 infection through antibody screening in Luanda, Angola

Cited by 6 publications

References 10 publications

Prevalence and Risk Factors of SARS-CoV-2 Infection among Parturients and Newborns from Luanda, Angola

Prevalence and Risk Factors of SARS-CoV-2 Infection among Parturients and Newborns from Luanda, Angola

The impact of the ABO/Rh blood group on susceptibility and severity among COVID-19 patients in Luanda, Angola

Immune profile of healthcare professionals six months after vaccination or exposure to SARS‐CoV‐2 in Angola

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