Serological Investigation of<i>Bartonella henselae</i>Infections in Clinically Cat‐Scratch Disease‐Suspected Patients, Patients with Cardiovascular Diseases, and Healthy Veterinary Students in Japan

Kikuchi, Eisaku; Maruyama, Soichi; Sakai, Takeo; Tanaka, Shigeo; Yamaguchi, Fukumitsu; Hagiwara, Toshikatsu; Katsube, Yasuji; Mikami, Takeshi

doi:10.1111/j.1348-0421.2002.tb02701.x

Cited by 18 publications

(20 citation statements)

References 17 publications

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“…The seroprevalence of B. henselae was 1.7% in veterinary-associated individuals. This prevalence was lower than in previous reports from Japan, which were 15% in veterinary professionals [20] and 10.9% in veterinary school students [17]. It was also lower than the 7.1% in the veterinary population that attended the veterinary Conference in Ohio, USA [30].…”

Section: Discussioncontrasting

confidence: 49%

“…Furthermore, year of experience with cats was the only identified variable associated with seropositivity [30]. There were also two serological investigations in veterinary populations in Japan [17,20]. Kumasaka et al [20] reported that 15% (35/233) of veterinary professionals were seropositive for B. henselae, and young female veterinary assistants and animal beauticians were more likely to be infected.…”

Section: Introductionmentioning

confidence: 99%

“…Kumasaka et al [20] reported that 15% (35/233) of veterinary professionals were seropositive for B. henselae, and young female veterinary assistants and animal beauticians were more likely to be infected. Kikuchi et al [17] reported that 10.9% (14/ 129) and 0.8% (1/129) of healthy veterinary students were IgG-and IgM-positive for B. henselae, respectively. History of catexposure was the main risk factor in this study population [17].…”

Section: Introductionmentioning

confidence: 99%

“…Kikuchi et al [17] reported that 10.9% (14/ 129) and 0.8% (1/129) of healthy veterinary students were IgG-and IgM-positive for B. henselae, respectively. History of catexposure was the main risk factor in this study population [17].…”

Section: Introductionmentioning

confidence: 99%

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Cat-scratch disease in veterinary-associated populations and in its cat reservoir in Taiwan

Chang

Lee²,

Maruyama³

et al. 2006

Vet. Res.

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-In Taiwan, the first human case of cat-scratch disease (CSD) was diagnosed by a serologic test in 1998. Since then, no studies have been conducted to understand the epidemiology of the infection in Taiwan. Therefore, this study is the first epidemiologic survey of CSD in cats and humans in this country. Using veterinary-associated individuals as the study population, it was identified that 1.7% of them were seropositive for B. henselae, and residence was the only factor associated with seropositivity. Bartonella species were successfully isolated from 25 (19.1%) of the 131 cats tested. Only B. henselae and B. clarridgeiae were obtained from bacteremic cats. Furthermore, 9.2% of 131 cats were dually-infected with genotypes I and II of B. henselae. It is the highest prevalence of co-infection that has ever been reported worldwide. In cats, the seroprevalence was 23.7% by indirect immunofluorescence antibody assay with B. henselae Houston-1 (type I) as the antigen. When 12 bacteremic but seronegative cats were re-tested by IFA slides coated with B. henselae U-4 antigen (type II), 9 cats were identified to be seropositive. Our study further suggested that using only direct PCR of 16S-23S rRNA intergenic region or the combination of the PCR method and indirect immuno-fluorescence test will be useful to diagnose Bartonella-free cats.Bartonella / cat scratch disease / cat / veterinary-associated population / Taiwan

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Section: Discussioncontrasting

confidence: 49%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Cat-scratch disease in veterinary-associated populations and in its cat reservoir in Taiwan

Chang

Lee²,

Maruyama³

et al. 2006

Vet. Res.

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“…Most cases are diagnosed based on clinical manifestations, the history of contacts with cats, serology (14,20,24,26,28,33) or PCR-based methods for examining the biopsy specimens (2, 10, 28). However, the isolation of the organism from patients is relatively difficult and only a few cases of the organism isolation have been reported worldwide (7,9,18,25), because suitable material is not available, the culture conditions are not appropriate or the organism shows fastidious, cytozoic and slow-growth properties.…”

mentioning

confidence: 99%

First Isolation of Bartonella henselae Type I from a Cat‐Scratch Disease Patient in Japan and Its Molecular Analysis

Maruyama

Izumikawa

Miyashita

et al. 2004

Microbiology and Immunology

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Cat-scratch disease (CSD) is a worldwide zoonosis primarily caused by Bartonella henselae (5,11,20,24,33,34), but Bartonella clarridgeiae has also been linked to a few human cases of CSD (17,19). The organism also causes bacillary angiomatosis (15,31) and peliosis (32) in immunocompromised individuals and bacteremia in immunocompetent individuals. The clinical manifestation of CSD is mainly characterized by pyrexia, papules on the site of the cat scratch or bite and unilateral lymphadenopathy, while cats themselves, the major reservoir of CSD, are asymptotic carriers, showing longterm bacteremia with antibody formation (1, 16).The number of human clinical cases of CSD has been increasing worldwide. Most cases are diagnosed based on clinical manifestations, the history of contacts with cats, serology (14,20,24,26,28,33) or PCR-based methods for examining the biopsy specimens (2, 10, 28). However, the isolation of the organism from patients is relatively difficult and only a few cases of the organism isolation have been reported worldwide (7,9,18,25), because suitable material is not available, the culture conditions are not appropriate or the organism shows fastidious, cytozoic and slow-growth properties. The isolation and establishment of Bartonella strains are extremely important for both etiological diagnosis and epidemiological and genetical analysis of the isolates. Though many clinical cases of CSD have been reported in Japan (20,24,33), there are to date no available reports of the isolation of B. henselae from human cases in Japan.B. henselae type II was detected in 18% of the isolates from CSD patients in the Netherlands (3), and 94% of cat isolates in Germany (27). In contrast, Maruyama et al. showed that type I is the predominant gene type in domestic cats in Japan (21). However, no data was available for the prevalence of gene type on the isolates from CSD patients in Japan.In this study, the authors describe a typical CSD case and the isolation of B. henselae from the patient in Medicine, Yame General Hospital, Fukuoka, Fukuoka 834-0034, Japan Received September 12, 2003; in revised form, October 27, 2003. Accepted November 20, 2003 Abstract: We isolated Bartonella henselae from an inguinal lymph node of a 36-year-old male patient with cat-scratch disease. The patient had many areas of erythema on his body, swelling of the left inguinal lymph nodes with pain and slight fever. The diagnosis was made on the basis of polymerase chain reaction for B. henselae DNA from the lymph node biopsies and blood sample, and isolation of the organism, histology of the lymph node and serology with an indirect immunofluorescent antibody test. We also analyzed the genome profiles for five strains of 90 isolates from the lymph node by pulsed-field gel electrophoresis after NotI endonuclease digestion. We found two different genomic profiles. These results suggest that the patient had been either co-infected or re-infected with two genetically different strains of B. henselae.

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Prevalence of Bartonella henselae Antibodies in Children and Blood Donors in Croatia

et al. 2009

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Serological Investigation ofBartonella henselaeInfections in Clinically Cat‐Scratch Disease‐Suspected Patients, Patients with Cardiovascular Diseases, and Healthy Veterinary Students in Japan

Cited by 18 publications

References 17 publications

Cat-scratch disease in veterinary-associated populations and in its cat reservoir in Taiwan

Cat-scratch disease in veterinary-associated populations and in its cat reservoir in Taiwan

First Isolation of Bartonella henselae Type I from a Cat‐Scratch Disease Patient in Japan and Its Molecular Analysis

Prevalence of Bartonella henselae Antibodies in Children and Blood Donors in Croatia

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