Serological markers in inflammatory bowel diseases

Reumaux, Dominique; Sendid, Boualem; Poulain, Daniel; Duthilleul, Patrick; Dewit, Olivier; Colombel, Jean–Frédéric

doi:10.1053/bega.2002.0347

Cited by 68 publications

(60 citation statements)

References 95 publications

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“…The opposite is true for patients with ulcerative colitis. 5 Given the temporal relationship between the use of large doses of sumatriptan and the onset of our patient's symptoms, the lack of infectious signs and symptoms, and the negative IBD studies, the gastroenterologist and the admitting team felt confident that the most likely diagnosis was ischemic colitis directly related to the use of sumatriptan.…”

Section: Casementioning

confidence: 93%

Ischemic Colitis Related to Sumatriptan Overuse

Hodge

Hodge²

2010

The Journal of the American Board of Family Medicine

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Background: Serotonin-1 5-hydroxytryptamine (5-HT 1) receptor agonists are first line agents for migraine headaches. Patients with refractory headaches may use supratherapeutic doses of these medications. Described is a case of ischemic colitis related to overuse of sumatriptan.Case: A 35-year-old woman presented with severe abdominal pain without diarrhea or hematochezia. For several days prior she had been self-treating a refractory migraine headache with frequent doses of sumatriptan. She is a nonsmoker and took no oral contraceptives or other serotonin agonists. A computed tomography scan of the abdomen revealed left-sided colitis. A colonoscopy with biopsy confirmed ischemic colitis and excluded inflammatory bowel disease (IBD).Discussion: Previously published case reports have suggested an association between 5-HT 1 receptor agonists and ischemic colitis. These reports have been dismissed because the patients were taking oral contraceptives, serotonin agonists, or had other comorbidities. This healthy patient lacked risk factors for ischemia, is the youngest to be reported, and is the first without hematochezia.Conclusion :

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Section: Casementioning

confidence: 93%

Ischemic Colitis Related to Sumatriptan Overuse

Hodge

Hodge²

2010

The Journal of the American Board of Family Medicine

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“…Several antibodies have been reported in serum from patients with both Crohn’s disease (CD) and ulcerative colitis (UC) [1]. Among these, two are the most studied: the anti-neutrophil cytoplasm autoantibodies (ANCA) [2] and the anti- Saccharomyces cerevisiae mannan antibodies (ASCA).…”

Section: Introductionmentioning

confidence: 99%

Diagnostic Value of Serological Assays in Pediatric Inflammatory Bowel Disorders

Mainardi

Villanacci²,

Bassotti

et al. 2007

Digestion

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Background: Pediatric studies reported that the combined use of the anti-neutrophil cytoplasm autoantibodies (ANCA) and the anti-Saccharomyces cerevisiae mannan antibodies (ASCA) may be a specific useful noninvasive test in the diagnosis of inflammatory bowel diseases (IBD). Aims: To evaluate the diagnostic accuracy of ANCA and ASCA in children with suspected IBD, and to see whether different commercially available assays (indirect immunofluorescence vs. ELISA) agree well enough in terms of analytical performance. Patients and Methods: Sixty-nine children (30 males, 39 females, age range 2–18 years) with suspicion of IBD entered the study. Before colonoscopy, a blood sample was also drawn to assess ASCA and ANCA. Results: A diagnosis of IBD was established in 47 patients; the remainder had infective or other causes of colitis. For ulcerative colitis, the association ASCA–/ANCA+ had 70% sensitivity and 86% specificity, with a positive predictive value of 82%. The association ASCA+/ANCA– had 86% sensitivity and 93% specificity for Crohn’s disease, with a positive predictive value of 75%. Conclusion: Although more experience is needed to state the diagnostic power of serologic assay, determination of ANCA and ASCA in IBD children may help both in distinguish these conditions from other entitiesand ulcerative colitis from Crohn’s disease, particularly in doubtful cases.

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“…[37][38][39][40] These biomarkers predict and are qualitatively and quantitatively associated with an aggressive and complicated course of Crohn's disease, including stricturing and/or penetrating phenotype, both in adult and paediatric patients. 13 However, a recent study showed that none of the anti-glycan antibodies ASCA, AMCA, ACCA, ALCA, anti-L and anti-C correlates with disease phenotype.…”

Section: Antimicrobial Antibodiesmentioning

confidence: 99%

Biomarkers of intestinal fibrosis – one step towards clinical trials for stricturing inflammatory bowel disease

Giuffrida

Pinzani

Corazza

et al. 2016

United European Gastroenterology Journal

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Intestinal fibrosis, caused by an excessive deposition of extracellular matrix components, and subsequent stricture development are a common complication of inflammatory bowel disease. However, currently there are no biomarkers which reliably predict the risk of developing intestinal strictures or identify early stages of fibrosis prior to clinical symptoms. Candidate biomarkers of intestinal fibrosis, including gene variants (i.e. nucleotide-binding oligomerization domain-2 gene), serum microRNAs (miR-19, miR-29), serum extracellular matrix proteins (i.e. collagen, fibronectin) or enzymes (i.e. tissue inhibitor of matrix metalloproteinase-1), serum growth factors (i.e. basic fibroblast growth factor, YKL-40), serum anti-microbial antibodies (i.e. anti-Saccharomyces cerevisiae) and circulating cells (i.e. fibrocytes) have shown conflicting results on relatively heterogeneous patients' cohorts, and none of them was proven to be strictly specific for fibrostenosis, but rather predictive of a disease disabling course. In this review we critically reassess the diagnostic and prognostic value of serum biomarkers of intestinal fibrosis in inflammatory bowel disease.

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Serological markers in inflammatory bowel diseases

Cited by 68 publications

References 95 publications

Ischemic Colitis Related to Sumatriptan Overuse

Ischemic Colitis Related to Sumatriptan Overuse

Diagnostic Value of Serological Assays in Pediatric Inflammatory Bowel Disorders

Biomarkers of intestinal fibrosis – one step towards clinical trials for stricturing inflammatory bowel disease

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