Serological Markers of Enterocyte Damage and Apoptosis in Patients With Celiac Disease, Autoimmune Diabetes Mellitus and Diabetes Mellitus Type 2

Hoffmanová, Iva; Sánchez, Daniel; Hábová, Věra; Andĕl, M; Tučková, Ludmila; Tlaskalová‐Hogenová, Helena

doi:10.33549/physiolres.932916

Cited by 41 publications

(35 citation statements)

References 49 publications

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“…LPS induce secretion of sCD14 from immune cells ; hence, high plasma levels of sCD14 are thought to reflect exposure to LPS . sCD14 is increased in conditions thought to be characterized by greater gut permeability such as celiac disease , potentially as a consequence of bacterial translocation across enterocytes . However, given that sCD14 is a non‐specific marker of monocyte activation that can be released from immune cells via other, non‐LPS dependent, mechanisms , any specificity as a biomarker of gut permeability is yet to be determined.…”

Section: Introductionmentioning

confidence: 99%

Leaky gut biomarkers in depression and suicidal behavior

Ohlsson

Gustafsson

Lavant

et al. 2018

Acta Psychiatr Scand

144

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Objective Inflammation is associated with major depressive disorder (MDD) and suicidal behavior. According to the ‘leaky gut hypothesis’, increased intestinal permeability may contribute to this relationship via bacterial translocation across enterocytes. We measured plasma levels of gut permeability markers, in patients with a recent suicide attempt (rSA), MDD subjects with no history of a suicide attempt (nsMDD), and healthy controls (HC), and related these markers to symptom severity and inflammation. Method We enrolled rSA (n = 54), nsMDD (n = 13), and HC (n = 17). Zonulin, intestinal fatty acid binding protein (I‐FABP), soluble CD14, and interleukin‐6 (IL‐6) were quantified in plasma. Montgomery–Åsberg Depression Rating Scale (MADRS) and Suicide Assessment Scale (SUAS) were used for symptom assessments. Results The rSA group displayed higher I‐FABP and lower zonulin levels compared with both the nsMDD and the HC groups (all P < 0.001). IL‐6 correlated positively with I‐FABP (r = 0.24, P < 0.05) and negatively with zonulin (r = −0.25, P < 0.05). In all subjects, I‐FABP levels correlated positively with MADRS (r = 0.25, P < 0.05) and SUAS scores (r = 0.38, P < 0.001), and the latter correlation was significant also in the nsMDD group (r = 0.60, P < 0.05). Conclusion The ‘leaky gut hypothesis’ may improve our understanding of the link between inflammation and suicidal behavior. These findings should be considered preliminary until replicated in larger cohorts.

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Section: Introductionmentioning

confidence: 99%

Leaky gut biomarkers in depression and suicidal behavior

Ohlsson

Gustafsson

Lavant

et al. 2018

Acta Psychiatr Scand

144

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“…Plasma levels of I-FABP are known to be a reliable biomarker of small intestine epithelial cell homeostasis in various enteropathies in adults and children [14,21,47]. Taking into consideration the very short halflife of this protein in circulation, the steady state circulating levels of I-FABP represents continuous release from senescent enterocytes.…”

Section: Discussionmentioning

confidence: 99%

“…Citrulline catabolism remains stable in absence of kidney disease and the small intestine therefore appears as the most important determinant of plasma citrulline levels. Reduced plasma citrulline levels were also documented in conditions characterized with lower enterocyte mass such as celiac disease, acquired immunodeficiency syndrome (AIDS), small intestine transplantation and sepsis-induced intestinal dysfunctions [14][15][16][17][18][19].…”

Section: Introductionmentioning

confidence: 99%

Plasma biomarkers of small intestine adaptations in obesity-related metabolic alterations

Lalande

Drouin‐Chartier

Tremblay

et al. 2020

Diabetol Metab Syndr

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Background: Evidence suggests that pathophysiological conditions such as obesity and type 2 diabetes (T2D) are associated with morphologic and metabolic alterations in the small intestinal mucosa. Exploring these alterations generally requires invasive methods, limiting data acquisition to subjects with enteropathies or undergoing bariatric surgery. We aimed to evaluate small intestine epithelial cell homeostasis in a cohort of men covering a wide range of adiposity and glucose homoeostasis statuses. Methods: Plasma levels of citrulline, a biomarker of enterocyte mass, and I-FABP, a biomarker of enterocyte death, were measured by UHPLC-MS and ELISA in 154 nondiabetic men and 67 men with a T2D diagnosis. Results: Plasma citrulline was significantly reduced in men with insulin resistance and T2D compared to insulin sensitive men. Decreased citrulline levels were, however, not observed in men with uncontrolled metabolic parameters during T2D. Plasma I-FABP was significantly higher in men with T2D, especially in presence of uncontrolled glycemic and lipid profile parameters. Integration of both parameters, which estimate enterocyte turnover, was associated with glucose homeostasis as well as with T2D diagnosis. Differences in biomarkers levels were independent of age and BMI and glucose filtration rates. Conclusions: Our study supports a decreased functional enterocyte mass and an increased enterocyte death rate in presence of metabolic alterations but emphasizes that epithelial cell homeostasis is especially altered in presence of severe insulin resistance and T2D. The marked changes in small intestine cellularity observed in obesity and diabetes are thus suggested to be part of gut dysfunctions, mainly at an advanced stage of the disease.

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“…Nach einjähriger glutenfreier Ernährung waren Negativierung von EMA und IgA-anti-tTG-Antikörpern ein guter Prädiktor für die Adhärenz zu einer glutenfreien Diät [113,114]. Eine Erfassung der Ernährungsgewohnheiten mittels Fragebögen [115,116] Künftig könnte die Bestimmung des intestinalen "Fatty Acid-Binding Protein" (I-FABP) ein sensitiver Marker für eine noch bestehende Schädigung der Dünndarmschleimhaut darstellen [117,118]. Bei Verwandten ersten Grades von Zöliakiepatienten (mögliche potenzielle Zöliakie) konnten damit auch diskrete Schleimhautläsionen [119] inkl.…”

Section: Wie Kann Die Adhärenz Zu Einer Glutenfreien Ernährung üBerprunclassified

Glutenfreie Ernährung – Update 2017

Leiß¹

2017

Z Gastroenterol

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Since sixty years, the gluten-free diet (GFD) is the only therapeutic option for patients with celiac disease or dermatitis herpetitormis to normalize symptoms and prevent complications. In recent years, the use of a gluten-free diet is rapidly growing because of presumed effects on well-being and control of body weight. GFD is becoming a popular health choice for everybody.In the present review, evidence-based indications for a gluten-free diet are stressed, the need for profound dietary counselling and education of the patient is underlined, problems and pitfalls of the implementation of a gluten-free diet in daily practice and possible side effects of long-term gluten-free diets are mentioned. New methods to control adherence to a gluten-free diet and aspects of nutritional quality of commercial gluten-free products are discussed in detail.

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Serological Markers of Enterocyte Damage and Apoptosis in Patients With Celiac Disease, Autoimmune Diabetes Mellitus and Diabetes Mellitus Type 2

Cited by 41 publications

References 49 publications

Leaky gut biomarkers in depression and suicidal behavior

Leaky gut biomarkers in depression and suicidal behavior

Plasma biomarkers of small intestine adaptations in obesity-related metabolic alterations

Glutenfreie Ernährung – Update 2017

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