Serological markers of erosive hand osteoarthritis

Ramonda, Roberta; Lorenzin, Mariagrazia; Modesti, Valentina; Campana, Carla; Ortolan, Augusta; Frallonardo, Paola; Punzi, Leonardo

doi:10.1016/j.ejim.2012.10.002

Cited by 23 publications

(19 citation statements)

References 40 publications

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“…Elevated levels of COMP are released during erosive joint disease such as rheumatoid arthritis and osteoarthritis [33]. The concentration of COMP in OA group was found to be increased over reference levels in the early stages of knee OA development.…”

Section: Discussionmentioning

confidence: 99%

A putative Chondroprotective role for IL-1β and MPO in herbal treatment of experimental osteoarthritis

Aborehab

Bishbishy

Refaiy

et al. 2017

BMC Complement Altern Med

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BackgroundHerbal treatment may have a chondroprotective and therapeutic effect on Osteoarthritis (OA). We investigated the mechanism of action of ginger and curcumin rhizomes cultivated in Egypt in treatment of OA in rat model.MethodsThirty-five albino rats were intra-articularly injected with Monosodium Iodoacetate in the knee joint. Ginger and curcumin was orally administered at doses of 200 and 400 mg/kg (F200 and F400). Serum levels of cartilage oligomeric matrix protein (COMP), hyaluronic acid (HA), malondialdehyde (MDA), myeloperoxidase (MPO), Interleukin-1 beta (IL-1β) and superoxide dismutase activity (SOD) were measured using ELISA. The composition of the herbal formula hydro-ethanolic extract was characterized using UPLC-ESI-MS. Histopathological changes in injected joints was examined using routine histopathology. Statistical analysis was performed using one-way ANOVA.ResultsSerum levels of COMP, HA, MPO, MDA, and IL-1β were significantly decreased in F 200, F 400 and V groups when compared to OA group (P value <0.0001). On the other hand SOD levels were significantly elevated in treated groups compared to OA groups (P value <0.0001).ConclusionsThe ginger/curcumin at 1:1 had chondroprotective effect via anti-inflammatory and antioxidant effect in rat OA model. Further pharmacological and clinical studies are needed to evaluate this effect.

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Section: Discussionmentioning

confidence: 99%

A putative Chondroprotective role for IL-1β and MPO in herbal treatment of experimental osteoarthritis

Aborehab

Bishbishy

Refaiy

et al. 2017

BMC Complement Altern Med

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“…Inflammatory factors such as IL-1β are indicators of the existence and severity of osteoarthritis. And IL-1β will promote the production of NO and accelerate the degradation of the cartilage by up-regulating the matrix metalloproteinase (MMP-1,13) and down-regulating the synthesis of the ECM [17]. So the concentration of IL-1β in the synovial fluid and in the serum would be obviously up-regulated, while there is barely any in normal joints.…”

Section: Discussionmentioning

confidence: 99%

A Comparison between Platelet-Rich Plasma (PRP) and Hyaluronate Acid on the Healing of Cartilage Defects

et al. 2014

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Platelet-rich plasma (PRP) has offered great promise for the treatment of cartilage degradation, and has been proved to have positive effects on the restoration of cartilage lesions. But no comparative work has been done between PRP and hyaluronate acid (HA) concerning their restoring effect on cartilage defect, especially by means of animal experiments and histologic assessments. The purpose of the study was to compare the therapeutic effects of P-PRP and HA on osteoarthritis in rabbit knees. Thirty rabbits were used to establish the animal models by creating a cartilage defect of 5 mm in diameter on the condyles of the femurs, and were randomly divided into three groups: the P-PRP group, HA group and the control group. Then each group was treated with P-PRP, HA or saline solution, respectively. Six and twelve weeks later the rabbits were sacrificed and the samples were collected. The platelet number, the concentrations of growth factors of P-PRP and whole blood, and the IL-1β concentration in the joint fluid were investigated, and the histological assessment of the cartilage were performed according to Mankin's scoring system. Micro-CT was also used to evaluate the restoration of subchondral bone. The platelet concentration in P-PRP is 6.8 fold of that in the whole blood. The IL-1β level in the P-PRP group was lower than in the HA group (p<0.01) and in the control group (p<0.01). The restoration of the defected cartilage as well as the subchondral bone was better in the P-PRP group than in the HA group or the control group (P<0.05). Our data showed that P-PRP is better than HA in promoting the restoration of the cartilage and alleviating the arthritis caused by cartilage damage.

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“…Furthermore, myeloperoxidase which is released by activated neutrophils is known to affect degradation of collagen components of cartilage via regulating oxidant factors [114], so that myeloperoxidase (MPO) is suggested as diagnostic marker for detection of early OA. In the erosive hand OA, increased value of serum MPO may reflex more expression of inflammatory signs.…”

Section: Inflammatory Markersmentioning

confidence: 99%

Review of Prospects of Biological Fluid Biomarkers in Osteoarthritis

Nguyen

Sharma

Chakraborty

et al. 2017

IJMS

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Osteoarthritis (OA) is a degenerative disease of the joints and is one of the leading causes of disability in adults. However, there are no key therapeutics for OA and medical treatment is based on managing the symptoms and slowing down progression of the disease. Diagnostics based on clinical examination and radiography have provided little information about metabolic changes in joint tissues, disease onset and progression. Due to lack of effective methods for early detection and evaluation of treatment outcome, the measurement of biochemical markers (biomarkers) shows promise as a prospective method aiding in disease monitoring. OA biomarkers that are present in biological fluids such as blood, urine and synovial fluid, sources that are easily isolated from body, are of particular interest. Moreover, there are increasingly more studies identifying and developing new biomarkers for OA. In this review, efforts have been made to summarize the biomarkers that have been reported in recent studies on patients. We also tried to classify biomarkers according to tissue metabolism (bone, cartilage and synovial metabolism markers), pathological pathways (inflammatory and genetic markers) and biological function (chemokines, growth factors, acute phase proteins, etc.).

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Serological markers of erosive hand osteoarthritis

Cited by 23 publications

References 40 publications

A putative Chondroprotective role for IL-1β and MPO in herbal treatment of experimental osteoarthritis

A putative Chondroprotective role for IL-1β and MPO in herbal treatment of experimental osteoarthritis

A Comparison between Platelet-Rich Plasma (PRP) and Hyaluronate Acid on the Healing of Cartilage Defects

Review of Prospects of Biological Fluid Biomarkers in Osteoarthritis

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