Serological markers of hepatitis B and C in patients with HIV/AIDS and active tuberculosis

Araújo-Mariz, Carolline; Lopes, Edmundo Pessoa; Ximenes, Ricardo A. A.; Lacerda, Heloísa Ramos; Miranda-Filho, Demócrito Barros; Montarroyos, Ulísses Ramos; Barreto, Silvana; Salustiano, Daniela Medeiros; Albuquerque, M. F. P. M.

doi:10.1002/jmv.24432

Cited by 8 publications

(10 citation statements)

References 24 publications

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“…There were no statistically significant associations between the prevalence of the viral infections and age (p > 0.05). This observation corresponds with report from similar studies [10,12,15,16]. This indicates that being young is a possible risk factor for contracting these viruses.…”

Section: Ethical Approvalsupporting

confidence: 92%

“…However, there was a statistically significant association among patients with respect to gender (p < 0.05). This observation did not correspond with previous findings [2,4,5,12,15]. There is no obvious reason for such outcome but it is probably related to the higher incidence of HIV and HBV infections in females which might predispose them to TB as the formers are known to activate dormant TB.…”

Section: Ethical Approvalcontrasting

confidence: 82%

“…Several studies report an increased coinfection with HIV and/or HBV in TB patients [2,[10][11][12]. However, there is paucity of published data on these viral infections among tuberculosis patients in Nigeria.…”

Section: Introductionmentioning

confidence: 99%

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Parallel and Overlapping Infection of Human Immunodeficiency Virus and Hepatitis B Virus Among Tuberculosis Patients Attending A Tuberculosis/Leprosy Referral Centre in Central Nigeria: A Cross-Sectional Study

Gri¹,

Oti²,

Ca³

2018

J Transl Gastroenterol Clin Hepatol

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Tuberculosis (TB) is a global health problem. Coinfection with Human Immunodeficiency Virus (HIV) and Hepatitis B virus (HBV) among TB patients has paved way for the resurgence of Mycobacterium tuberculosis infection as well as increased risk of hepatotoxicity during tuberculosis therapy. There is paucity of published data on HIV/HBV infection in TB patients in Nigeria. This was a baseline study carried out to determine coinfection of HIV and HBV in Tuberculosis confirmed patients attending a TB/Leprosy referral healthcare Centre in Central Nigeria. Blood samples were collected from 400 confirmed TB patients and their sociodemograph information were obtained using a structured questionnaire. Samples were analyzed for anti-HIV and HbsAg using Enzyme Linked Immunosorbent Assay (J. Mitra and Co. Pvt. Ltd, India and Shantha Biotechnics Ltd, India respectively). Data were analyzed using SSP version 2.80. P value ≤ 0.05 was considered statistically significant. Of the 400 patients, 68(17.0%) tested positive for HIV and 48(12.0%) for HBV while 6 (1.5%) had HIV/HBV coinfection. Gender, history of STI, history of HBV vaccine and educational status were associated risk factors for the viral infection. Age, history of blood transfusion and scarification mark did not show any statistically significant association to the viral infections. The prevalence rates of HIV and HBV recorded in this population is a cause for alarm. There is therefore a need to introduce the monitoring of TB patients for therapyrelated hepatotoxicity and performance of these viral infections.

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Section: Ethical Approvalsupporting

confidence: 92%

Section: Ethical Approvalcontrasting

confidence: 82%

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Parallel and Overlapping Infection of Human Immunodeficiency Virus and Hepatitis B Virus Among Tuberculosis Patients Attending A Tuberculosis/Leprosy Referral Centre in Central Nigeria: A Cross-Sectional Study

Gri¹,

Oti²,

Ca³

2018

J Transl Gastroenterol Clin Hepatol

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“…Diagnosis of HIV seropositivity during the screening of tuberculosis is common [33]. In addition, among the HIV infected person, HCV co-infection is more prevalent due to overlapping transmission routes (sexual, parenteral and vertical) [34].…”

Section: Discussionmentioning

confidence: 99%

Screening for HBV, HCV, HIV and syphilis infections among bacteriologically confirmed tuberculosis prisoners: An urgent action required

et al. 2019

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Viral hepatitis, syphilis, HIV, and tuberculosis infections in prisons have been identified globally as a public health problem. Tuberculosis (TB) and viral hepatitis co-infection may increase the risk of anti-tuberculosis treatment-induced hepatotoxicity, leading to the frequent cause of discontinuation of the first-line anti-tuberculosis drugs. Therefore, the aim of this cross-sectional study was to investigate the epidemiological features of HCV, HBV, syphilis and HIV infections among bacteriologically confirmed tuberculosis prisoners in Campo Grande (MS), Central Brazil. The participants who agreed to participate (n = 279) were interviewed and tested for the presence of active or current HCV, HBV, syphilis and HIV infections. The prevalence of HCV exposure was 4.7% (13/279; 95% CI 2.2–7.1). HCV RNA was detected in 84.6% (11/13) of anti-HCV positive samples. Out of 279 participants, 19 (6.8%; 95% CI 4.4–10.4) were HIV co-infected, 1.4% (4/279, 95% CI 0.5–3.8) had chronic hepatitis B virus (HBsAg positive) and 9.3% (26/279, 95% CI 6.4–13.4) had serological marker of exposure to hepatitis B virus (total anti-HBc positive). The prevalence of lifetime syphilis infection (anti- T . pallidum positive) was 10% (28/279, 95% CI 7.0–14.2) and active syphilis (VDRL ≥ 1/8 titre) was 5% (14/279, 95% CI 2.9–8.3). The prevalence of TB/HCV co-infection among prisoners with HIV (15.8%) was higher than among HIV-non-infected prisoners (3.8%; P <0.05). These results highlight the importance of hepatitis testing among prisoners with bacteriologically confirmed case of TB who can be more effectively and safely treated in order to reduce the side effects of hepatotoxic anti-TB drugs.

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“…The prevalence of hepatitis B viral infection among tuberculosis patients ranges from 0.5 to 44% [8][9][10][11]. Hepatitis C virus burden among tuberculosis patients ranges from 3.4 -44.6% [12][13][14].…”

Section: Introductionmentioning

confidence: 99%

Impacts of hepatitis B and hepatitis C co-infection with tuberculosis, a prospective cohort study

Feleke

Adane

et al. 2020

Virol J

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Background This study was conducted to estimate the prevalence, determinants of hepatitis B, hepatitis C and the survival of tuberculosis patients until drug-induced hepatitis. Methods Prospective cohort study design was implemented. The data were collected from September 2016 – May 2019. Systematic random sampling was used to select the study participants. Baseline data were collected before the patient starts DOTS, the sign of liver toxicity was assessed every week. Tuberculosis treatment outcomes and WHO clinical stage was recorded at the end of 6th months. Descriptive statistics were used to estimate the prevalence of hepatitis B, hepatitis C viral infections and their effect on tuberculosis treatment outcomes. Binary logistic regression was used to identify the determinants of hepatitis B and C infections. The Kaplan Meier survival curve was used to estimate the survival of tuberculosis patient and Cox regression was used to identify the predictors of drug-induced hepatitis. Results A total of 3537 tuberculosis patients were followed. The prevalence of hepatitis B and C viral infection among tuberculosis patients were 15.1 and 17.3% respectively. Hepatitis B viral infection among tuberculosis patients was associated with alcohol, sex, HIV, chronic illness. Hepatitis C viral infection among tuberculosis patients was associated with alcohol, sex, HIV, chronic illness. The incidence density for liver toxicity among tuberculosis patients was 843/15707 person-months and liver toxicity was determined by HIV, Hepatitis B, Hepatitis C, the severity of tuberculosis and chronic illnesses. Conclusion Decision-makers should consider incorporating screening for hepatitis B and C viral infection during tuberculosis treatment.

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Serological markers of hepatitis B and C in patients with HIV/AIDS and active tuberculosis

Cited by 8 publications

References 24 publications

Parallel and Overlapping Infection of Human Immunodeficiency Virus and Hepatitis B Virus Among Tuberculosis Patients Attending A Tuberculosis/Leprosy Referral Centre in Central Nigeria: A Cross-Sectional Study

Parallel and Overlapping Infection of Human Immunodeficiency Virus and Hepatitis B Virus Among Tuberculosis Patients Attending A Tuberculosis/Leprosy Referral Centre in Central Nigeria: A Cross-Sectional Study

Screening for HBV, HCV, HIV and syphilis infections among bacteriologically confirmed tuberculosis prisoners: An urgent action required

Impacts of hepatitis B and hepatitis C co-infection with tuberculosis, a prospective cohort study

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