Serological markers of persistent C. trachomatis infections in women with tubal factor subfertility

Hartog, J.E. den; Land, J. A.; Stassen, Frank R. M.; Kessels, Alfons G.H.; Bruggeman, C. A.

doi:10.1093/humrep/deh710

Cited by 69 publications

(52 citation statements)

References 25 publications

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“…These high oestrogen levels may stimulate the production of CRP in the liver, resulting in a CRP pattern strongly different from the one seen in spontaneous, non-stimulated cycles. Similarly, elevated CRP levels have been found in women using oral contraceptives (37,38) and also in women with tubal factor subfertility due to persistent Chlamydia trachomatis infection (39). Another theoretical explanation could be the fact that in contrast to physiological cycles, 5000-10 000 IU of human chorionic gonadotrophin (hCG) is administered in IVF treatment cycles.…”

Section: Discussionmentioning

confidence: 99%

Serum leptin and C-reactive protein levels in the physiological spontaneous menstrual cycle in reproductive age women

Wunder¹,

Yared²,

Bersinger³

et al. 2006

eur j endocrinol

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Objective: Only a few studies have investigated variations of different markers for inflammatory processes during the physiological menstrual cycle. The results are conflicting, particularly concerning the correlation between the marker leptin and steroid hormones. The aim of the study was to investigate the inflammatory markers C-reactive protein (CRP) and leptin in the serum of healthy, normally ovulating women and to correlate these with each other and with the hormones of the gonadal axis. A cycle-dependence of the markers studied would imply an exact timing of the blood sampling for clinical needs. Design: Observational study investigating the two inflammatory markers CRP and leptin in relation to the hormonal pattern of the gonadal axis during the normal cycle. Methods: Ovulatory cycles of 36 healthy, young, normo-androgenic women, having a normal body mass index were evaluated. Serum concentrations of leptin and CRP, as well as of follicle-stimulating hormone, luteinising hormone, 17b-oestradiol, progesterone, prolactin (PRL) and free testosterone were measured every 1-2 days during one full cycle. Results: Serum levels of leptin and CRP behaved differently during ovulatory cycles, with higher concentrations for leptin only during certain phases. Significant correlations were found in the follicular phase between leptin and PRL and leptin and free testosterone. Conclusions: Leptin levels change during the menstrual cycle. Leptin levels are more stable on cycle days 1-5 than later in the cycle. For precise cycle-independent measurements, these fluctuations have to be taken into account. There is no similar cyclic pattern for CRP.European Journal of Endocrinology 155 137-142

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Section: Discussionmentioning

confidence: 99%

Serum leptin and C-reactive protein levels in the physiological spontaneous menstrual cycle in reproductive age women

Wunder¹,

Yared²,

Bersinger³

et al. 2006

eur j endocrinol

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“…3,15,16 It is the most prevalent and most active in causing tubal damage of all sexually transmitted diseases. 7,[16][17][18][19] Presumably the increasing incidence of infertility is consequent to a rising incidence of tubal infection with C. trachomatis and other sexually transmitted pathogens. It is estimated that in western countries and Nigeria by the end of one year of unprotected sexual intercourse, 10-15% and about 30% respectively of couples will fail to conceive.…”

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confidence: 99%

Burden of Chlamydia trachomatis infection amongst infertile women compared with pregnant controls in North-central Nigeria

2017

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Background: Female infertility due to tubal damage resulting from pelvic infections including Chlamydia trachomatis is common among women in our environment. The study aimed at determining the prevalence of Chlamydia trachomatis antibody amongst infertile women and to assess the relationship between exposure to Chlamydia trachomatis infection and tubal infertility in Garki Hospital, Abuja, Nigeria.Methods: This was a case control study among 76 infertile patients with tubal occlusion diagnosed with hysterosalpingography and confirmed by laparoscopy compared with 81 pregnant women recruited from the antenatal clinic. Both cases and control were investigated with a study protocol which solicited information on socio-demographic variables, sexual and reproductive risk factors and history of previous pelvic infection. Each subject and control had 5 ml of blood collected for serological assay for Chlamydial antibody titre using the immunocomb Chlamydia trachomatis 1gG kit. The data was analyzed using the SPSS version 20 (IBM, Armonk, NY, USA). A p-value of < 0.05 was considered statistically significant.Results: The prevalence of serum Chlamydial antibody was 57 (75.0%) and 19 (23.5%) among the cases and the pregnant controls respectively (P-value < 0.001). The results showed statistically significant associations between tubal infertility and early age at sexual debut, three or more sexual partners, nulliparity and positive Chlamydia trachomatis antibody titre (P-values < 0.001).Conclusions: The prevalence of Chlamydia trachomatis antibody titre was higher among women with infertility compared to the pregnant controls. The findings suggest that tubal infertility is associated with exposure to Chlamydial trachomatis infection.

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“…Bias ini juga dibahas pada penelitian lain yang serupa dan menjadi salah satu kekurangan yang disadari. 21 Bila dilihat secara kualitatif, kadar antibodi terhadap IgG Chlamydia trachomatis yang diperiksa dengan metode ELISA tampak berbeda antara kelompok dengan tuba fallopi yang mengalami kerusakan dan yang normal (gambar 1). Berdasarkan uji MannWhitney U didapatkan hasil bahwa distribusi kadar antibodi IgG Chlamydia trachomatis berbeda signifikan antara kelompok tuba fallopi rusak dan normal dengan nilai p = 0.…”

Section: Pemeriksaan Igg Chlamydia Trachomatisunclassified

Tingginya Infeksi Chlamydia trachomatis pada Kerusakan Tuba Fallopi Wanita Infertil

Sariroh

Primariawan

2015

MOG

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Tujuan: Untuk mengetahui gambaran infeksi C. trachomatis pada kerusakan tuba fallopi wanita infertil. Bahan dan Metode: Penelitian ini melibatkan 42 wanita yang menjalani laparoskopi dalam tata laksana infertilitasnya. Infeksi C. trachomatis diperiksa menggunakan metode PCR dari usapan endoserviks dan IgG C. trachomatis diperiksa menggunakan metode ELISA dari darah vena. Kondisi tuba fallopi dilakukan evaluasi saat laparoskopi. Hasil: Didapatkan C. trachomatis sebesar 14,29% dari PCR usapan endoserviks dan 38,10% dari IgG C. trachomatisdi darah. Sebagian besar tuba fallopi pada subyek dengan infeksi C. trachomatis menunjukkan kerusakan, ditandai adanya adhesi perituba, oklusi tuba, fimosis fimbria atau hidrosalping saat laparoskopi. IgG C. trachomatis berbeda signifikan pada kerusakan tuba fallopi (p = 0. 01), sedangkan endometriosis dan riwayat operasi sebagai faktor risiko tidak didapatkan perbedaan yang signifikan (p = 0. 26 dan p = 0. 27). Subyek dengan IgG C. trachomatis memiliki OR: 5. 5 (95% CI 1. 42-21. 7)untuk terjadi kerusakan tuba fallopi. IgG C. trachomatis memiliki sensitifitas 62,5%, spesifisitas 81,25%, PPV 62,5% dan NPV 81,25% dalam mendeteksi kerusakan tuba fallopi bila dikonfirmasi dengan hasil laparoskopi. Simpulan: Angka kejadian infeksi C. trachomatis pada wanita infertil cukup tinggi. Pemeriksaan IgG C. trachomatis dapat menjadi penanda adanya kerusakan tuba fallopi.Kata Kunci: C. trachomatis, infertilitas, kerusakan tuba fallopi, IgG, PCR Objectives: To know the description of C. trachomatis infection in tubal dysfunction of infertile women Materials and Methods: This study involves 42 women who underwent laparoscopy procedure in their infertility work up. Chlamydia trachomatis was detected using PCR from endocervical swabs and IgG was detected using ELISA from blood. Evaluation of the fallopian tube was done during laparoscopy procedure. Results: C. trachomatis was detected in 14,29% by PCR of endocervical swab and IgGin serum was detected in 38,10%. Most of the infected women in this study have fallopian tube dysfunction, confirmed by laparoscopic visualization of peritubal adhesion, tubal occlusion, fimbriae phimosis, or hydrosalphing. IgG C. trachomatis is significantly different between normal and dysfunctional fallopian tube (p = 0. 01). The occurrence of endometriosis and previous surgery was not statistically different (p = 0. 26 and p = 0. 27). Women with IgG C. trachomatis had OR: 5. 5 to get fallopian tube dysfunction(95% CI, 1. 42-21. 7). IgG C. trachomatis has sensitivity of 62. 5% and specificity of 81. 25%, PPV of 62,5% and NPV of 81,25% in detecting dysfunctional tube compared to laparoscopy. Conclusion:The incidence of C. trachomatis infection is quite high in infertile women. IgG Chlamydia trachomatis can be used as a marker of fallopian tube dysfunction. Keywords: Chlamydia trachomatis, infertility, fallopian tube dysfunction, IgG, PCRCorrespondence: Wafi Sariroh, Departemen Obstetri dan Ginekologi, Fakultas Kedokteran Universitas Airlangga, RSUD Dr. Soetomo, Sur...

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Serological markers of persistent C. trachomatis infections in women with tubal factor subfertility

Cited by 69 publications

References 25 publications

Serum leptin and C-reactive protein levels in the physiological spontaneous menstrual cycle in reproductive age women

Serum leptin and C-reactive protein levels in the physiological spontaneous menstrual cycle in reproductive age women

Burden of Chlamydia trachomatis infection amongst infertile women compared with pregnant controls in North-central Nigeria

Tingginya Infeksi Chlamydia trachomatis pada Kerusakan Tuba Fallopi Wanita Infertil

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