Serological observations in patients suffering from acute manic episodes

Wadee, Ahmed A.; Kuschke, Reverie H.; Wood, Lesley; Berk, Michael; Ichim, Liuvu; Maes, Michaël

doi:10.1002/hup.390

Cited by 94 publications

(57 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…All this is consistent with episode-specific differential gene expression of PTGDS and AKR1C3 as revealed in the present case. Alterations in inflammatory markers in serum of bipolar patients, such as cytokines, c-reactive protein and components of the complement system, have been reported previously (32)(33)(34)(35)(36)(37)(38). There might well be an interaction between the prostaglandin system found to be episodically regulated here, in the described case, and these inflammatory molecules, also in the CNS (35,39,40).…”

supporting

confidence: 72%

Episode-Specific Differential Gene Expression of Peripheral Blood Mononuclear Cells in Rapid Cycling Supports Novel Treatment Approaches

Begemann

Sargin

Rossner

et al. 2008

Mol Med

View full text Add to dashboard Cite

Molecular mechanisms underlying bipolar affective disorders are unknown. Difficulties arise from genetic and phenotypic heterogeneity of patients and the lack of animal models. Thus, we focused on only one patient (n = 1) with an extreme form of rapid cycling. Ribonucleic acid (RNA) from peripheral blood mononuclear cells (PBMC) was analyzed in a three-tiered approach under widely standardized conditions. Firstly, RNA was extracted from PBMC of eight blood samples, obtained on two consecutive days within one particular episode, including two different consecutive depressive and two different consecutive manic episodes, and submitted to (1) screening by microarray hybridizations, followed by (2) detailed bioinformatic analysis, and (3) confirmation of episode-specific regulation of genes by quantitative real-time polymerase chain reaction (qRT-PCR). Secondly, results were validated in additional blood samples obtained one to two years later. Among gene transcripts elevated in depressed episodes were prostaglandin D synthetase (PTGDS) and prostaglandin D2 11-ketoreductase (AKR1C3), both involved in hibernation. We hypothesized them to account for some of the rapid cycling symptoms. A subsequent treatment approach over 5 months applying the cyclooxygenase inhibitor celecoxib (2 × 200 mg daily) resulted in reduced severity rating of both depressed and manic episodes. This case suggests that rapid cycling is a systemic disease, resembling hibernation, with prostaglandins playing a mediator role.

show abstract

supporting

confidence: 72%

Episode-Specific Differential Gene Expression of Peripheral Blood Mononuclear Cells in Rapid Cycling Supports Novel Treatment Approaches

Begemann

Sargin

Rossner

et al. 2008

Mol Med

View full text Add to dashboard Cite

show abstract

“…C-reactive protein, a proinflammatory marker elevated in systemic inflammation and involved in chronic inflammatory processes, was elevated during both manic and depressive episodes [13]. In some studies such an elevation was found only in manic states [14,15], and in some it was higher in mania than in depression [16]. Depression has been accompanied by an elevation of C-reactive protein and treatment of the depressive symptoms resulted in its reduction [17,18].…”

Section: Introductionmentioning

confidence: 99%

Selected Cytokine Profiles during Remission in Bipolar Patients

Remlinger-Molenda

Wójciak

Michalak³

et al. 2012

Neuropsychobiology

View full text Add to dashboard Cite

Objectives: The aim of the study was to examine the cytokine status in bipolar patients during immediate remission after acute episodes of mania or depression and in patients with sustained (≥6 months) remission, compared with healthy controls. Methods: The study was performed on 121 bipolar patients, of whom 35 were in immediate remission after mania, 41 were in immediate remission after depression, and 45 were in >6-month remission on lithium monotherapy or lithium combined with other drugs. The control group consisted of 78 healthy individuals without any history of psychiatric or immunological illnesses. Serum concentrations of IL-1β, IL-2, IL-6, IL-10, TNF-α and IFN-γ were determined using the Human Th1/Th2 Cytometric Bead Array method. Results: The concentration of IL-10 was higher in patients in remission after mania and the concentration of IFN-γ was higher in those in remission after depression than in healthy controls. On the other hand, cytokine concentrations in patients with sustained remission were not different from those of healthy subjects. Conclusions: The results obtained in this study show that sustained remission in bipolar patients achieved mostly by lithium maintenance brings the cytokine status to a level similar to healthy control subjects.

show abstract

“…These discrepancies may be explained by heterogeneity in mood state, methodological differences, and not controlling for known confounds, such as obesity (6). In addition to inflammatory markers, increasing production of antibodies (20 -22) and immunoglobulins (23,24) may be implicated with BD.…”

mentioning

confidence: 99%

Antibody Profiling of Bipolar Disorder Using Escherichia coli Proteome Microarrays

Chen

Syu

Chung

et al. 2015

Molecular & Cellular Proteomics

View full text Add to dashboard Cite

To profile plasma antibodies of patients with bipolar disorder (BD), an E. coli proteome microarray comprising ca. 4200 proteins was used to analyze antibody differences between BD patients and mentally healthy controls (HCs). The plasmas of HCs and patients aged 18 -45 years with bipolar I disorder (DSM-IV) in acute mania (BD-A) along with remission (BD-R) were collected. The initial samples consisting of 19 BD-A, 20 BD-R, and 20 HCs were probed with the microarrays. After selecting protein hits that recognized the antibody differences between BD and HC, the proteins were purified to construct BD focus arrays for training diagnosis committees and validation. Additional six BD-A, six BD-R, six HCs, and nine schizophrenic disorder (SZ, as another psychiatric control) samples were individually probed with the BD focus arrays. The trained diagnosis committee in BD-A versus HC combined top six proteins, including rpoA, thrA, flhB, yfcI, ycdU, and ydjL. However, the optimized committees in BD-R versus HC and BD-A versus BD-R were of low accuracy (< 0.6). In the single blind test using another four BD-A, four HC, and four SZ samples, the committee of BD-A versus HC was able to classify BD-A versus HC and SZ with 75% sensitivity and 80% specificity that both HC and SZ were regarded as negative controls. The consensus motif of the six proteins, which form the committee of BD-A versus HC, is [KE]DIL[AG]L[LV]I[NL][IC][SVKH]G[LV][VN][LV] byGapped Local Alignment of Motifs. We demonstrated that the E. coli proteome microarray is capable of screening BD plasma antibody differences and the selected proteins committee was successfully used for BD diagnosis with

show abstract

Serological observations in patients suffering from acute manic episodes

Cited by 94 publications

References 17 publications

Episode-Specific Differential Gene Expression of Peripheral Blood Mononuclear Cells in Rapid Cycling Supports Novel Treatment Approaches

Episode-Specific Differential Gene Expression of Peripheral Blood Mononuclear Cells in Rapid Cycling Supports Novel Treatment Approaches

Selected Cytokine Profiles during Remission in Bipolar Patients

Antibody Profiling of Bipolar Disorder Using Escherichia coli Proteome Microarrays

Contact Info

Product

Resources

About