Serological Parameters and Vascular Investigation for a Better Assessment in DVT during Pregnancy—A Systematic Review

Abstract

Pregnancy and the postpartum period represent a condition characterized by a thrombotic predisposition. The majority of pregnant women do not face acute or severe thrombotic events. In general, mild inconveniences such as leg swelling or moderately painful thrombotic events (phlebitis) are encountered. However, when pregnancy is associated with inherited or acquired deficits that affect homeostasis, the risk of acute or even life-threatening events can increase significantly. The major consequence is the loss of the fetus or the venous thromboembolism that endangers the mother’s life. Venous thromboembolism is caused by deep vein thrombosis, therefore timely detection and especially the assessment of the extent of the thrombotic event are crucial. In this paper we have summarized the most important paraclinical investigations. The study emphasizes the importance of selecting the methods of investigation. The right choice allows establishing a correct diagnosis and individualizing the treatment.

The effect of low molecular weight heparin combined with air pressure in the prevention of lower extremity venous thrombosis after cesarean section: A single-center retrospective study

“…[ 25 ] Almost all coagulation factors increas to varying degrees during the middle of the pregnancy, and peak at the time of delivery. [ 26 ] Post-operatively, patients are usually advised bed-rest for 24 hours. The reduced activity of the lower limbs as well as reduced mobility leads to slowing and stasis of the blood flow, predisposing these patients to the development of deep vein thrombosis.…”

Managing Fetal Ovarian Cysts: Clinical Experience with a Rare Disorder

“…Differential diagnosis is an important step in the prenatal and postnatal evaluation of fetal ovarian cysts, as many other abdominal or pelvic masses can mimic this pathology [19,20], and serological markers could be helpful in the postnatal differentiation of various types of masses [21,22]. Thus, we included only cases with highly suggestive ultrasound appearances of FOC in our study.…”

Hereditary Thrombophilia in the Era of COVID-19

“…To date, a large number of studies indicate that Hcy is an independent risk factor for cardiovascular disease and that there is a higher correlation between homocysteine and atherosclerosis levels than between cholesterol and atherosclerosis levels [ 78 , 83 ]. Hcy is thought to be associated with vascular dysfunction through the following mechanisms: generation of reactive species (ROS), triggering/maintaining the inflammatory response; initiation of thrombotic phenomena [ 80 , 84 ]. Endothelial dysfunction is one of the major events in the pathogenic mechanism of cardiovascular disease.…”

“…The literature indicates a link between homocysteine and reactive species. Hcy is a risk factor for thrombophilia and is associated with both venous thrombosis and arterial thrombosis [ 84 ]. A study by Ridker et al, over a period of 10 years, showed that the combination of hyperhomocysteinemia and Leiden factor V further increases the risk of venous thromboembolism [ 88 ].…”