Serological Prediction of infections in Diabetic Patients with Diabetes Ketoacidosis in Penang, Malaysia

Gillani, Syed Wasif; Sulaiman, Syed Azhar Syed; Sundram, Shameni; Sari, Yelly Oktavia; Baig, Mirza Sharif Ahmed; Iqbal, Mian Muhammad Shahid

doi:10.4314/tjpr.v11i5.16

Cited by 2 publications

(2 citation statements)

References 21 publications

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“…In my study, the maximum number of Diabetics with infection were seen in 50 -59 years' age group (78.3%). This increase in incidence of infection with age was observed in a study by Gillani et al [27] However there was no statistical significance with age and infection in my study. In my study the infection rate was higher among females (53.7%).…”

Section: Table -2 Association Between With and Without Infection Amon...supporting

confidence: 46%

Clinical Profile and Risk Assessment of Infections Among Diabetics in a Community Health Hospital in Chennai: A Hospital Based Descriptive and Cross-Sectional Study

Shribalaji¹,

Naganathan²,

Chacko³

2021

Int J Med Sci and Nurs Res

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Background: Incidence of diabetes mellitus continues to rise, common focus areas for diabetes control are blood glucose levels, diet, and exercise. Controlling these factors are essential for a better quality of life in diabetes patients. Patients with diabetes have an increased risk of asymptomatic bacteriuria and pyuria, cystitis, and, more important, serious upper urinary tract infection. Materials and Methods: This was a hospital based descriptive and cross-sectional study which included 250 Study subjects who were admitted in CSI Kalyani General hospital during the period from July 2017 to July 2018 and who has Diabetic as a comorbidity were interviewed using structured protocol based proforma. Patient underwent routine clinical, pathological and biochemical investigations. Results: In this study, 250 in-patients were included and analyzed. The prevalence of Infection in Diabetes mellitus was 65.6%. There is no significant association between Age, Education, Occupation, HbA1C, Duration and type of treatment and biochemical values. The commonest organism in Urine sample among the study group was E.coli followed by Klebsiella. UTI is more common in females, Respiratory infection is more common in males and it is statistically significant (p<0.009) and it is statistically significant (p<0.007). Conclusion: From this study, we have concluded that patient with diabetes mellitus is at increased risk for common infections due to poor glycemic control and Obesity. Poor glycemic control suppresses the immunity and more prone for infection. Therefore, the challenges will be to attain good glycemic control, change in lifestyle to maintain normal BMI. This will prevent the morbimortality, reduce the long-term complication and maintenance to prolong the life without any sequele. More prospective case control studies on the management of infections in DM patients are needed. Keywords: type 2 diabetes mellitus, infections, clinical profile, hba1c, glycemic control

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Section: Table -2 Association Between With and Without Infection Amon...supporting

confidence: 46%

Clinical Profile and Risk Assessment of Infections Among Diabetics in a Community Health Hospital in Chennai: A Hospital Based Descriptive and Cross-Sectional Study

Shribalaji¹,

Naganathan²,

Chacko³

2021

Int J Med Sci and Nurs Res

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“…In a series of 967 patients admitted with DKA, 176 had a viral infection (presumed). The mean blood glucose in these 176 patients was 640.0 mg/dl, not strikingly different from that seen in the COVID-19 patients [ 44 ]. However, patients presenting with DKA/HHS had significantly higher blood glucose than patients with isolated DKA, a feature that has been described in the literature [ 29 ].…”

Section: Discussionmentioning

confidence: 67%

Clinical profile and outcomes in COVID-19 patients with diabetic ketoacidosis: A systematic review of literature

Pal

Banerjee

Yadav

et al. 2020

Diabetes & Metabolic Syndrome: Clinical Research & Revi

102

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Background and aim To conduct a systematic literature review and analyze the demographic/biochemical parameters and clinical outcomes of COVID-19 patients with diabetic ketoacidosis (DKA) and combined DKA/HHS (hyperglycemic hyperosmolar syndrome). Methods PubMed, Scopus, Embase, and Google Scholar databases were systematically searched till August 3, 2020 to identify studies reporting COVID-19 patients with DKA and combined DKA/HHS. A total of 19 articles reporting 110 patients met the eligibility criteria. Results Of the 110 patients, 91 (83%) patients had isolated DKA while 19 (17%) had DKA/HHS. The majority of the patients were male (63%) and belonged to black ethnicity (36%). The median age at presentation ranged from 45.5 to 59.0 years. Most of the patients (77%) had pre-existing type 2 diabetes mellitus. Only 10% of the patients had newly diagnosed diabetes mellitus. The median blood glucose at presentation ranged from 486.0 to 568.5 mg/dl, being higher in patients with DKA/HHS compared to isolated DKA. The volume of fluid replaced in the first 24 h was higher in patients with DKA/HHS in contrast to patients with DKA alone. The in-hospital mortality rate was 45%, with higher mortality in the DKA/HHS group than in the isolated DKA group (67% vs. 29%). pH was lower in patients who had died compared to those who were discharged. Conclusion DKA in COVID-19 patients portends a poor prognosis with a mortality rate approaching 50%. Differentiating isolated DKA from combined DKA/HHS is essential as the latter represents nearly one-fifth of the DKA cases and tends to have higher mortality than DKA alone.

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Serological Prediction of infections in Diabetic Patients with Diabetes Ketoacidosis in Penang, Malaysia

Abstract: Purpose: To determine the prevalence and predictors of infection in diabetic patients

Cited by 2 publications

References 21 publications

Clinical Profile and Risk Assessment of Infections Among Diabetics in a Community Health Hospital in Chennai: A Hospital Based Descriptive and Cross-Sectional Study

Clinical Profile and Risk Assessment of Infections Among Diabetics in a Community Health Hospital in Chennai: A Hospital Based Descriptive and Cross-Sectional Study

Clinical profile and outcomes in COVID-19 patients with diabetic ketoacidosis: A systematic review of literature

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