Serological response to Bartonella species in febrile patients from Nepal

Myint, Khin Saw Aye; Gibbons, Robert V.; Iverson, Jennifer; Shrestha, Sanjaya; Pavlin, Julie A.; Mongkolsirichaikul, Duangrat; Kosoy, Michael

doi:10.1016/j.trstmh.2011.08.002

Cited by 13 publications

(5 citation statements)

References 6 publications

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“…We tested the positive human serum samples for 3 other Bartonella species ( B. henselae , B. quintana , and B. elizabethae ) that circulate in Africa, and we did not detect any positive results. Given that immunofluorescence assays have good discriminatory ability for a wide range of antigens ( 40 – 42 ), the results lead us to conclude that the antibodies in these participants were indeed reactive with B. rousetti but not the other Bartonella species tested, although cross-reactivity with other non- Bartonella agents cannot be ruled out.…”

Section: Discussionmentioning

confidence: 90%

Human Exposure to NovelBartonellaSpecies from Contact with Fruit Bats

Bai¹,

Osinubi²,

Osikowicz³

et al. 2018

Emerg. Infect. Dis.

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Twice a year in southwestern Nigeria, during a traditional bat festival, community participants enter designated caves to capture bats, which are then consumed for food or traded. We investigated the presence of Bartonella species in Egyptian fruit bats (Rousettus aegyptiacus) and bat flies (Eucampsipoda africana) from these caves and assessed whether Bartonella infections had occurred in persons from the surrounding communities. Our results indicate that these bats and flies harbor Bartonella strains, which multilocus sequence typing indicated probably represent a novel Bartonella species, proposed as Bartonella rousetti. In serum from 8 of 204 persons, we detected antibodies to B. rousetti without cross-reactivity to other Bartonella species. This work suggests that bat-associated Bartonella strains might be capable of infecting humans.

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Section: Discussionmentioning

confidence: 90%

Human Exposure to NovelBartonellaSpecies from Contact with Fruit Bats

Bai¹,

Osinubi²,

Osikowicz³

et al. 2018

Emerg. Infect. Dis.

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“…McVea et al (2018) reported exposure to ratassociated Bartonella species among intravenous drug users in an impoverished neighborhood of Vancouver, Canada. A retrospective serological survey of archived specimens indicated that Bartonella antibodies are prevalent among febrile patients in the Kathmandu Valley of Nepal (Myint et al, 2011). When 11 cases with high titers were compared to eight different Bartonella antigens, the highest titers (ranged from 1:256 to 1:2,048) reported in three patients were against the antigen of B. elizabethae.…”

Section: Rat-associated Bartonellosis In Humansmentioning

confidence: 99%

Bartonella Bacteria in Urban Rats: A Movement From the Jungles of Southeast Asia to Metropoles Around the Globe

Kosoy

Bai

2019

Front. Ecol. Evol.

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Despite the widespread recognition of the risks of disease transmission associated with international trade in domestic animals and movement of exotic animals, less is known about the role of rats in carrying pathogens between continents. The genus Bartonella, a highly prevalent and extremely diverse group of bacteria, includes species that are excellent sentinel organisms for evaluating the transoceanic and intra-continental movement of the pathogens carried by rats of the genus Rattus. The patterns of spatial distribution, occurrence, and genetic diversity of Bartonella species infecting rats and their arthropod ectoparasites depend on the geographic locations within metropolitan areas of the Americas, Africa, Asia, and Europe. One of the points addressed in this review is a comparison of the diversity of Bartonella species carried by rats in their original habitats in Southeast Asia and in the cities occupied by rats recently. The invasion of Rattus rats into new urban territories create significant risk for human health.

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“…In addition, B. vinsonii subsp. arupensis –specific antibodies were reported in febrile patients from Nepal ( 10 ). Together, these reports suggest that the spectrum of animal hosts carrying B. vinsonii subsp.…”

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confidence: 99%