Serological Responses of FldA and Small‐Molecular‐Weight Proteins of Helicobacter pylori: Correlation with the Presence of the Gastric MALT Tissue

Abstract

Patients with gastric MALT and dense lymphoid follicles had different anti-H. pylori serological responses to those with scanty or an absence of lymphoid follicles. The negative seroconversion of the smaller-molecular-weight proteins, but not CagA and FldA, may correlate with the regression of MALT by H. pylori eradication.

The Family Helicobacteraceae

“…Although the mechanisms of tumorigenesis in MALT lymphoma have not been clearly demonstrated, H. pylori flavodoxin A has been associated with an increased risk of developing gastric MALT lymphoma (Chang et al 1999;Yang et al 2004).…”

“…infection than in H. pylori infection Morgner et al 2000). Of note, a homologus fldA encoding the flavodoxin A of H. pylori that has been associated with an increased risk of gastric MALT lymphoma has been detected in H. suis (Chang et al 1999;Yang et al 2004). The eradication of H. heilmannii s.l.…”

Flavodoxins: sequence, folding, binding, function and beyond

“…This is of great interest since they include human pathogens such as Helicobacter pylori [39]. Flavodoxin is thus a potential target for drug design [39,[104][105][106]. Indeed, the flavodoxin from Helicobacter pylori displays a peculiar structural feature that can be exploited to bind inhibitory molecules next to the active site [9].…”

Quantitative Analysis of Representative Proteome Components and Clustering of Helicobacter pylori Clinical Strains

“…More than 30 immunogenic proteins, including heat‐shock protein 60 (GroEL), 50S ribosomal proteins, and catalase, have been identified [36]. Alkyl hydroperoxide reductase (AhpC/TsaA), 3‐dehydroquinase II, elongation factor P (EF‐P), GroEL, inorganic pyrophosphatase (Ppa), ATPase alpha, and flavodoxin (FldA) have been examined for strain specificity or disease association [37–40].…”