Serological studies on patients with suspected legionellosis in New Zealand

Chereshsky, A; Rv, Metcalfe; Bettelheim, K. A.

doi:10.1007/bf01642804

Cited by 7 publications

(15 citation statements)

References 6 publications

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“…that year is the result of low awareness of the availability of Legionella testing and the limited range of antigens available for testing either using DFA or IFA [29]. By 1985 New Zealand was testing against 11 different Legionella spp.…”

Section: Discussionmentioning

confidence: 99%

Changing epidemiological trends of legionellosis in New Zealand, 1979–2009

Graham

White²,

Harte

et al. 2011

Epidemiol. Infect.

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SUMMARYThis study evaluated the spatio-temporal variation of Legionella spp. in New Zealand using notification and laboratory surveillance data from 1979 to 2009 and analysed the epidemiological trends. To achieve this we focused on changing incidence rates and occurrence of different species over this time. We also examined whether demographic characteristics such as ethnicity may be related to incidence. The annual incidence rate for laboratory-proven cases was 2 . 5/100 000 and 1 . 4/100 000 for notified cases. Incidence was highest in the European population and showed large geographical variations between 21 District Health Boards. An important finding of this study is that the predominant Legionella species causing disease in New Zealand differs from that found in other developed countries, with about 30-50% of cases due to L. longbeachae and a similar percentage due to L. pneumophila for any given year. The environmental risk exposure was identified in 420 (52 %) cases, of which 58 % were attributed to contact with compost ; travel was much less significant as a risk factor (6 . 5 %). This suggests that legionellosis has a distinctive epidemiological pattern in New Zealand.

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Section: Discussionmentioning

confidence: 99%

Changing epidemiological trends of legionellosis in New Zealand, 1979–2009

Graham

White²,

Harte

et al. 2011

Epidemiol. Infect.

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“…Both patients had a previous history of immunological disorders treated with steroids (idiopathic thrombocytopenic purpura and rheumatoid arthritis, respectively), possibly rendering them more susceptible to infection. Pleural effusion was also present in the three previously reported cases of human L. oakridgensis infection (4,10,11), suggesting that this species might produce specific virulence factors (adhesins and/or extracellular products) favoring tropism for pleural tissue.…”

mentioning

confidence: 70%

“…L. oakridgensis was originally isolated from water in the environment (7,13) and was subsequently found to be responsible for several human cases of pleurisy (4,10,11). However, these human infections were diagnosed by DFA on clinical specimens and were not confirmed by culture of the organism (4, 10, 11).…”

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confidence: 99%

Isolation of Legionella oakridgensis from Two Patients with Pleural Effusion Living in the Same Geographical Area

et al. 2000

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“…L. pneumophila serogroup 1 is the most commonly isolated agent, while other legionellae are recovered only rarely [21]. Therefore, the lower sensitivity of the ELISA was not a consequence of a lack of detection of antibodies to L. micdadei .…”

Section: Discussionmentioning

confidence: 99%

Comparison of serologic tests with urinary antigen detection for diagnosis of legionnaires’ disease in patients with community-acquired pneumonia

Sočan

Marinič-Fišer

Keše

1999

Clinical Microbiology and Infection

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OBJECTIVE: To compare serologic methods and detection of urinary antigen in the diagnosis of community-acquired pneumonia. METHODS: Paired sera from 84 patients with community-acquired pneumonia were tested for Legionella pneumophila serogroup (LP SG) 1-7 and Legionella micdadei by use of the indirect immunofluorescence antibody test (IIF), enzyme-linked immunosorbent assay (ELISA) for LP SG 1-7 and complement-fixation (CF) test for LP SG 1. All patients were evaluated by ELISA urinary antigen detection for LP SG 1. RESULTS: Seven patients met the CDC criteria for acute Legionella infection, while in the rest of them we failed to detect urinary Legionella antigen. Thirty-three patients had non-diagnostic IIF antibody titers. Serum ELISA (IgG and/or IgM) was positive in 40 patients. Nine patients showed at least one CF titer of >/=1:32. The sensitivities of ELISA IgM for the first and the second serum samples compared with IIF were 42.8% and 46.6%, respectively, while the specificities were higher, i.e. 87% and 88.4%, respectively. The sensitivities of ELISA IgG for the first and the second samples were 42.8% and 53.3%, and the specificities were 77.9% and 76.8%, respectively. CONCLUSIONS: Although ELISA is simple to perform and easy to automate, we think that its advantages over indirect immunofluorescence and urinary antigen detection remain questionable.

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Serological studies on patients with suspected legionellosis in New Zealand

Cited by 7 publications

References 6 publications

Changing epidemiological trends of legionellosis in New Zealand, 1979–2009

Changing epidemiological trends of legionellosis in New Zealand, 1979–2009

Isolation of Legionella oakridgensis from Two Patients with Pleural Effusion Living in the Same Geographical Area

Comparison of serologic tests with urinary antigen detection for diagnosis of legionnaires’ disease in patients with community-acquired pneumonia

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