Serological Survey for the Major Viral Diseases in the Layers

Lee, Hae Rim; Kim, Jong Man; Kim, Jin Hyung; Kim, Chang Moon; So, Hyun Hee; Lee, Dong Woo; Ha, Bong Do; Hong, Song; Mo, In-Pil

doi:10.5536/kjps.2010.37.4.361

Cited by 8 publications

(13 citation statements)

References 24 publications

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“…Previous studies indicated that APMV type 1 and 4 fell into the same subgroup (Lipkind et al, 1986). Further, there were concerns of possible cross reaction between APMV type 1 and 4 due to the high titer and almost all positive serum rates (Lee et al, 2010) of APMV type 1 considering massive vaccination in the poultry industry (Warke et al, 2008b). Thus, the nonexistence of cross reaction between the La Sota strain, APMV type 1 and the strains selected in this study was considered to be significant and confirmed the reliability of the serological test results.…”

Section: Discussionmentioning

confidence: 72%

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Epidemiological Studies of Avian Paramyxovirus Type 4 and 6 in Commercial Chicken Flocks in Korea

Lee¹,

Koo²,

Jeon³

et al. 2013

Korean Journal of Poultry Science

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Avian paramyxovirus (APMV) type 4 and 6 were isolated during an avian influenza (AI) surveillance program of wild birds. This study also conducted experimental infection of wild-bird-origin APMV type 4 and 6 in specific pathogen free (SPF) chickens to study pathogenicity and transmission within domestic flocks. In addition, serological prevalence data of APMV type 4 and 6 in domestic fowls was conducted with chicken sera collected from 2007 to 2009 in order to understand infection status. The results of the animal experiment showed that APMV type 4 and 6 had the ability to infect chickens with sero-conversion and to transmit the virus from infected birds to contacted birds, but showed low pathogenicity. Serological tests revealed that APMV type 4 was widespread in the poultry industry, especially in layer flocks, but the positive rate for APMV type 6 was very low. This study concluded that wild bird-origin APMV type 4 and 6 could infect the chickens by inter-species transmission and the seroprevalence of APMV type 4 was quite high in Korean poultry. However, since almost all the chicken flocks had a high level of antibody titer against APMV type 1, there was possibility of cross reaction between APMV type 1 and 4, which made the interpretations more complicated. In order to understand infection status in the natural environment, additional study is necessary regarding the seroprevalence of APMV type 4 and 6 in the wild bird population.(Key words : avian paramyxovirus type 4 and 6, experimental infection, inter-species transmission, seroprevalence, commercial chicken flocks) † To whom correspondence should be addressed : moip@cbu.ac.kr

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Section: Discussionmentioning

confidence: 72%

“…The serum samples were from layers, breeders, and broilers flocks and divided into seven age classes considering the effect of maternal antibodies and growth or production stages (Lee et al, 2010).…”

Section: ) Serum Samplesmentioning

confidence: 99%

Epidemiological Studies of Avian Paramyxovirus Type 4 and 6 in Commercial Chicken Flocks in Korea

Lee¹,

Koo²,

Jeon³

et al. 2013

Korean Journal of Poultry Science

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“…Despite the abundance of serologic tests, only limited comprehensive analysis of the results has been conducted. The majority of the serologic surveys in Korea have been conducted on breeder focusing on trans-ovarian transmission disease such as salmonellosis or mycoplasmosis (Lee et al, 2010). In case of layers, despite their importance layers in Korean poultry industry, serologic studies on layers have been limited even compared to breeders.…”

Section: Introductionmentioning

confidence: 99%

“…This discrepancy seems to occur from the absence of effective management of serologic data and wellestablished criteria. Recently, studies on major viral diseases in layers using serologic survey methods were published (Lee et al, 2010). This study analyzed 5,385 serum samples collec- …”

Section: Introductionmentioning

confidence: 99%

“…In layer and breeder flocks, which chickens are periodically bred for a long time, serologic tests are actively conducted to monitor flock health and to evaluate the efficacy of vaccine programs (Saif et al, 2011;Sharma, 1999). Diseases which have negative effect on egg production and requiring extensive management include: Low pathogenic avian influenza (LPAI), Infectious bronchitis (IB), Avian meta-pneumoviral infection and Egg drop syndrome' 76 (EDS'76) (Lee et al, 2010;Mo et al, 2003;McFerran, 1979;Song et al, 1998;Sugiyama et al, 2006). On the other hand, the diseases which affects the immune system such as Chicken infectious anemia (CIA) and Infectious bursal disease (IBD) are also regarded as key diseases for monitoring because of their ability to undermine vaccine efficacy (Boer et al, 1994;Lee et al, 2010;Kibenge et al, 1988;Otaaki et al, 1988;Otaki et al, 1988).…”

Section: Introductionmentioning

confidence: 99%

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Serological Survey of Major Avian Viral Diseases Related with Egg Production in Commercial Chicken Flocks in Korea

Jang¹,

Lee²,

Koo³

et al. 2014

Korean Journal of Poultry Science

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While use of mass rearing systems improved poultry production, chances of exposing to contagious diseases have been increased, making flocks more vulnerable to diseases. Diseases of interest which affects egg production adversely include Low pathogenic avian influenza (LPAI), Infectious bronchitis (IB), Avian meta-pneumoviral infection (aMPV) and Egg drop syndrome'76 (EDS'76). This report collected and analyzed 5,385 serum samples, which were collected from 1,330 different chicken flock, provided by Chungbuk National University, Avian Disease Laboratory at 2009. Serums were analyzed based on rearing stages; 0∼1.3weeks (wks) (maternal antibody period), >1.3∼3 wks (starting period), >3∼10 wks (growing period), >10∼22 wks (developing period), >22∼40 wks (peak laying period), >40∼60 wks (late laying period) and over 60 wks (post-molting period). Results showed the 99.7% of the tested flocks were immunized against ND and73.8%, 97.1%, 78,2% and 78% of the flocks were immunized against other 4 agents (LPAI, IB, EDS'76, aMPV). Maternal antibody was transferred to enough quantity for NDV. Generally, antibody titers which were developed at 22 weeks were stabilized permanently for life. In case of IB and aMPV, infection titer emerged as early as 10 weeks and the titer was increased from 99.4% to 100% for life. EDS76 showed increase in titers, reflecting decreased frequency of vaccination programs. Overall, this study displayed general trends of major viral disease in layers, but considering the trend of development of preventive measures and evolution of pathogens, conducting serological surveys on a regular basis is important.(Key words : serological survey, avian influenza, infectious bronchitis, avian metapenumovirus, commercial layer) † To whom correspondence should be addressed : moip@cbu.ac.kr

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Efficacy of a novel avian metapneumovirus live vaccine candidate based on vaccination route and age

Youn

Noh²,

Kim³

et al. 2021

Poultry Science

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This article describes a series of animal studies for the development of an avian metapneumovirus ( aMPV ) live vaccine. Although aMPV causes continual economic loss in the poultry industry, there are no live aMPV vaccines available in Korea. Furthermore, information is limited with respect to standard field practices for vaccinations at an early age. Here, the development of an aMPV live vaccine was attempted, and its efficacy was investigated with respect to the vaccination route and age to develop a method for controlling aMPV. Before vaccine development, an animal challenge model was established using the aMPV field isolate to identify the most effective time and site for collecting samples for evaluation. After attenuation of the virulent aMPV in Vero cells, a safety and efficacy test was conducted for the vaccine candidate. As a novel aMPV live vaccine candidate, aMPV K655/07HP displayed sufficient safety in day-old chicks with 10 vaccine doses. The efficacy test using 1-week-old chicks showed weaker humoral immune response than that in 4-week-old chicks. However, the candidate vaccine provided complete protection against infection caused by the challenge virus for all ages of vaccinated chicks. In conclusion, an effective aMPV challenge model was established for studying aMPV in chickens, which offered important, insightful information. The safety and efficacy study suggested that the new aMPV candidate vaccine could be used to effectively reduce the economic losses incurred because of aMPV infection.

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Serological Survey for the Major Viral Diseases in the Layers

Cited by 8 publications

References 24 publications

Epidemiological Studies of Avian Paramyxovirus Type 4 and 6 in Commercial Chicken Flocks in Korea

Epidemiological Studies of Avian Paramyxovirus Type 4 and 6 in Commercial Chicken Flocks in Korea

Serological Survey of Major Avian Viral Diseases Related with Egg Production in Commercial Chicken Flocks in Korea

Efficacy of a novel avian metapneumovirus live vaccine candidate based on vaccination route and age

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