Serological survey of SARS-CoV-2 in companion animals in China

Wang, Aiping; Zhu, Xifang; Chen, Yumei; Sun, Yong; Liu, Hongliang; Ding, Peiyang; Zhou, Jingming; Liu, Yankai; Liang, Chao; Yin, Jun; Zhang, Gaiping

doi:10.3389/fvets.2022.986619

Cited by 5 publications

(8 citation statements)

References 51 publications

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“…In summary, our data confirmed that cats and dogs in close contact with people can develop an antibody response against SARS-CoV-2 infection, and similar to other studies, the seroprevalence of SARS-CoV-2 among cats and dogs belonging to owners of unknown COVID-19 status was low [ 28 , 29 , 30 , 31 , 32 ]. This study also highlights the need to establish species-specific serological assays that can assess neutralizing antibodies in companion animals to provide accurate measurements of active infection in households and communities to ensure that all transmission opportunities are prevented.…”

Section: Discussionsupporting

confidence: 91%

“…Natural SARS-CoV-2 infection has been sporadically detected in companion animals, with human-to-animal transmission suspected in almost all cases [ 16 , 21 , 22 , 23 , 24 , 25 , 26 , 27 ]. Serological surveillance of cats and dogs has been conducted in different countries since the early phases of the COVID-19 pandemic [ 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 ]. Specifically, the seroprevalence of SARS-CoV-2 in cats with an unknown history of exposure to the virus was found to be 0.015% (2/13397) in China [ 28 ], 0.69% (6/920) in Germany [ 29 ], 0.76% (1/131) in Croatia [ 30 ], 0.4% (2/500) in the Netherlands [ 31 ], 3.3% (15/451) in Italy [ 32 ], 18.9% (46/243) in Poland [ 33 ] and 7.3% (40/547) in Brazil [ 34 ].…”

Section: Introductionmentioning

confidence: 99%

“…Serological surveillance of cats and dogs has been conducted in different countries since the early phases of the COVID-19 pandemic [ 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 ]. Specifically, the seroprevalence of SARS-CoV-2 in cats with an unknown history of exposure to the virus was found to be 0.015% (2/13397) in China [ 28 ], 0.69% (6/920) in Germany [ 29 ], 0.76% (1/131) in Croatia [ 30 ], 0.4% (2/500) in the Netherlands [ 31 ], 3.3% (15/451) in Italy [ 32 ], 18.9% (46/243) in Poland [ 33 ] and 7.3% (40/547) in Brazil [ 34 ]. In dogs, the seroprevalence was 0.014% (1/7159) in China [ 28 ], 0.31% (2/654) in Croatia [ 30 ], 0.2% (1/500) in the Netherlands [ 31 ], 3.3% (15/451) in Italy [ 32 ] and 16% in Poland (62/388) [ 33 ].…”

Section: Introductionmentioning

confidence: 99%

“…Specifically, the seroprevalence of SARS-CoV-2 in cats with an unknown history of exposure to the virus was found to be 0.015% (2/13397) in China [ 28 ], 0.69% (6/920) in Germany [ 29 ], 0.76% (1/131) in Croatia [ 30 ], 0.4% (2/500) in the Netherlands [ 31 ], 3.3% (15/451) in Italy [ 32 ], 18.9% (46/243) in Poland [ 33 ] and 7.3% (40/547) in Brazil [ 34 ]. In dogs, the seroprevalence was 0.014% (1/7159) in China [ 28 ], 0.31% (2/654) in Croatia [ 30 ], 0.2% (1/500) in the Netherlands [ 31 ], 3.3% (15/451) in Italy [ 32 ] and 16% in Poland (62/388) [ 33 ]. Not surprisingly, the seroprevalence of animals from COVID-19-affected households was generally higher than in those with unknown exposure, ranging from 10% to 12.8% in dogs and 4.5% to 43.8% in cats [ 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 ].…”

Section: Introductionmentioning

confidence: 99%

“…In dogs, the seroprevalence was 0.014% (1/7159) in China [ 28 ], 0.31% (2/654) in Croatia [ 30 ], 0.2% (1/500) in the Netherlands [ 31 ], 3.3% (15/451) in Italy [ 32 ] and 16% in Poland (62/388) [ 33 ]. Not surprisingly, the seroprevalence of animals from COVID-19-affected households was generally higher than in those with unknown exposure, ranging from 10% to 12.8% in dogs and 4.5% to 43.8% in cats [ 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 ]. Increases in seroprevalence were also reported between the first and second waves of the pandemic; in Germany, the seroprevalence of SARS-CoV_2 increased from 0.65% to 1.36% in cats [ 29 , 39 ], while in the UK it increased from 0–2.2%% in cats and from 0–1.4% in dogs [ 40 ].…”

Section: Introductionmentioning

confidence: 99%

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Low Prevalence of SARS-CoV-2 Antibodies in Canine and Feline Serum Samples Collected during the COVID-19 Pandemic in Hong Kong and Korea

Carrai

Choi

et al. 2023

Viruses

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Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has affected millions of people worldwide since its emergence in 2019. Knowing the potential capacity of the virus to adapt to other species, the serological surveillance of SARS-CoV-2 infection in susceptible animals is important. Hong Kong and Seoul are two of Asia’s most densely populated urban cities, where companion animals often live in close contact with humans. Sera collected from 1040 cats and 855 dogs during the early phase of the pandemic in Hong Kong and Seoul were tested for SARS-CoV-2 antibodies using an ELISA that detects antibodies against the receptor binding domain of the viral spike protein. Positive sera were also tested for virus neutralizing antibodies using a surrogate virus neutralization (sVNT) and plaque reduction neutralization test (PRNT). Among feline sera, 4.51% and 2.54% of the samples from Korea and Hong Kong, respectively, tested ELISA positive. However, only 1.64% of the samples from Korea and 0.18% from Hong Kong tested positive by sVNT, while only 0.41% of samples from Korea tested positive by PRNT. Among canine samples, 4.94% and 6.46% from Korea and Hong Kong, respectively, tested positive by ELISA, while only 0.29% of sera from Korea were positive on sVNT and no canine sera tested positive by PRNT. These results confirm a low seroprevalence of SARS-CoV-2 exposure in companion animals in Korea and Hong Kong. The discordance between the RBD-ELISA and neutralization tests may indicate possible ELISA cross-reactivity with other coronaviruses, especially in canine sera.

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Section: Discussionsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Low Prevalence of SARS-CoV-2 Antibodies in Canine and Feline Serum Samples Collected during the COVID-19 Pandemic in Hong Kong and Korea

Carrai

Choi

et al. 2023

Viruses

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SARS-CoV-2 exposure in hunting and stray dogs of southern Italy

Ferrara,

Pagnini,

Montagnaro

2024

Vet Res Commun

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Evidence of exposure to the pandemic SARS-CoV-2 has been described in numerous animal species, including pets, which are predisposed to coming into contact with this virus due to their close relationship with owners. It has been accepted that dogs are poorly susceptible to this virus and that seroconversion, rather than shedding, occurs following infection, which can occur directly through contact with infected owners or indirectly through environmental contamination. In this study, the seroprevalence of SARS-CoV-2 was evaluated in apparently health hunting and stray dogs of Campania region, southern Italy (sampled in September 2023). A total of 5/112 (4.5%) animals tested seropositive using two different commercial ELISAs. Stray animals had greater exposure than hunting dogs. The feces and blood of each animal were tested with a real-time PCR targeting the nucleocapsid and ORF1ab coding sequences. No animal tested positive in molecular investigations, indicating a past exposure without active infection at the time of sampling.

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