Serological survey of toxoplasmosis in the Santa Cruz region of Bolivia

Paradisi, Franco; Bartoloni, Alessandro; Aquilini, Donatella; Roselli, Mimmo; Núñez, Lorena; Manzone, Giovanni; Majo, E. De; Parri, F.

doi:10.1016/0035-9203(89)90651-2

Cited by 6 publications

(2 citation statements)

References 3 publications

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“…A prevalência de 66% de soropositividade para a toxoplasmose na população humana da zona rural de Jaguapitã está de acordo com os resultados obtidos por diversos autores, ainda que em localidades diferentes e com a utilização de diferentes testes sorológicos (6,9,17,(29)(30)(31)(32). Contudo, os resultados observados no presente estudo diferem dos dados obtidos por Goldsmith et al (33) no México, onde foi observada uma prevalência de 4% na população rural.…”

Section: Discussionunclassified

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Soroprevalência, epidemiologia e avaliação ocular da toxoplasmose humana na zona rural de Jaguapitã (Paraná), Brasil

Garcia

Navarro

Ogawa³

et al. 1999

Rev Panam Salud Publica

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Toxoplasmosis is a protozoal zoonosis common among a great variety of species worldwide. The objective of this study was to assess the presence of toxoplasmosis among 345 residents in a rural area in Jagupitã municipality, Paraná state, Brazil. The frequency of titers in human serum samples was compared with the frequency of titers found in 1,420 samples obtained from various animal species with which local residents came into contact. Titers > or = 16 were considered positive. The highest titer found was 65,536 (1%), and the most frequent titer levels were 256 (29%) and 1,024 (19%). The comparisons between humans and animals revealed a positive and significant correlation between humans and felines (r = 0.78; P = 0.01) and humans and canines (r = 0.64; P = 0.05) in terms of titer distribution. Study participants were also tested with the Amsler grid. Seventy-five of the 345 people (22%) reported some type of ocular degradation. Of these 75, 58 of them (77%) were seropositive for toxoplasmosis. Forty-one of these 58 people underwent an ophthalmologic exam. Of these 41, 9 of them, who were between 34 and 78 years old, presented lesions characteristic of healed chorioretinitis, suggesting ocular toxoplasmosis. None of the 9 had ocular inflammation. Six of the 9 patients (67%) had unilateral lesions; 4 of these 6 presented a titer level of 256. The epidemiological survey showed that the probability of presenting ocular problems was 2.06 times as great for reactive patients as for nonreactive ones. No significant differences were observed in terms of sex, contact with felines or other animals, consumption of raw or rare meat and raw milk, and slaughtering of animals for personal consumption. Our results suggest that toxoplasmosis is common in the region, with a significant incidence of ocular lesions caused by Toxoplasma gondii. Health authorities should increase their monitoring and control activities in order to decrease the risk of toxoplasmic infections, especially among pregnant women.

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“…O presente inquérito revelou uma soropositividade proporcional à faixa etária, resultado também já citado na literatura (6,9,24,29,(31)(32)(33). Observou-se uma prevalência de 44% entre meninas menores do que 15 anos, e de 70% entre mulheres com idades entre 16 e 40 anos.…”

Section: Discussionunclassified

Soroprevalência, epidemiologia e avaliação ocular da toxoplasmose humana na zona rural de Jaguapitã (Paraná), Brasil

Garcia

Navarro

Ogawa³

et al. 1999

Rev Panam Salud Publica

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Toxoplasma gondii Infection: A Feline Zoonosis with Potential Dangers for the Unborn Foetus and AIDS Sufferer

Cook

1990

Parasitic Disease in Clinical Practice

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Synthesis and evaluation of some pyrimidine analogs against toxoplasmosis

et al. 2008

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Toxoplasmosis is a worldwide infection caused by the obligate intracellular protozoan parasite Toxoplasma gondii. Some pyrimidine analogs were synthesized to be evaluated for their antitoxoplasma effects in animal experiments. Results were assessed by studying parasite density, estimation of serum Toxoplasma antigen, studying the ultrastructural changes of the parasite, and the histopathological changes of the affected organs and inhibitory activity for dihydrofolate reductase (DHFR) isolated from Cryptosporidium parvum. The result showed that 4 out of 12 synthesized compounds have promising antitoxoplasma potentials. The animals that received these four compounds showed statistically significant decrease in the mean number of the parasite count in the liver and the spleen when compared to the corresponding control group. Moreover, Toxoplasma antigen was very low or even absent in the serum of animals receiving these compounds. Light microscopic examination of the peritoneal exudates of animals receiving these compounds showed stoppage of movement and deformity in shape of the tachyzoites, whereas scanning electron microscopy revealed that the organisms had lost their crescent shape, with dimples and deep ridges on their surfaces. Very mild histopathological changes were noticed in liver, spleen, and lungs of the groups of animals receiving these compounds in comparison to the other groups. Thus, these compounds proved their effectiveness in eradication of the experimental Toxoplasma infection and inhibition of DHFR from C. parvum.

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Serological survey of toxoplasmosis in the Santa Cruz region of Bolivia

Cited by 6 publications

References 3 publications

Soroprevalência, epidemiologia e avaliação ocular da toxoplasmose humana na zona rural de Jaguapitã (Paraná), Brasil

Soroprevalência, epidemiologia e avaliação ocular da toxoplasmose humana na zona rural de Jaguapitã (Paraná), Brasil

Toxoplasma gondii Infection: A Feline Zoonosis with Potential Dangers for the Unborn Foetus and AIDS Sufferer

Synthesis and evaluation of some pyrimidine analogs against toxoplasmosis

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