Serological Tests for Staphylococcal Infection

Lack, C. H.; Towers, A. G.

doi:10.1136/bmj.2.5314.1227

Cited by 42 publications

(24 citation statements)

References 4 publications

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“…and novobiocin 5 ,ug. Serum anticz-lysin titres were measured using the method described by Lack & Towers (1962).…”

Section: Methodsmentioning

confidence: 99%

The bacteriology of tropical pyomyositis in Uganda

Foster

1965

Epidemiol. Infect.

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1. The bacteriology of the pus from 79 cases of tropical pyomyositis has been studied. In 74 cases Staphylococcus aureus was isolated in pure culture.2. Phage typing showed that 60% of the pyomyositis strains belonged to phage Group II as compared with 22% for miscellaneous hospital infections and 21% for nasal carrier strains.3. A high proportion of the Group II strains from pyomyositis were found to be penicillin resistant and it is thought that this is unlikely to be due to the use of penicillin therapeutically but is probably a natural characteristic of the strains.4. Other suggested aetiological factors in pyomyositis such as leptospirosis and syphilis have been investigated but no association has been found.5. The phage types of staphylococci found in Uganda have been compared with those reported from England and Australia and found not to be strikingly different.

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“…and novobiocin 5 ,ug. Serum anticz-lysin titres were measured using the method described by Lack & Towers (1962).…”

Section: Methodsmentioning

confidence: 99%

The bacteriology of tropical pyomyositis in Uganda

Foster

1965

Epidemiol. Infect.

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“…However, it is well recognized that a raised anti-alpha haemolysin titre is found only in about two-thirds of patients who have staphylococcal bone infections (Queneau, Lejeune, Bertoye, Bouvier, Bertrand, and Perrier, 1972). At the Royal National Orthopaedic Hospital during the past 12 years a second staphylococcal antibody, antileucocidin, has also been quantitated as recommended by Towers and Gladstone (1958) and Lack and Towers (1962), using an indirect haemagglutination technique (Towers, 1961). Although lacking specificity this is the only simple method available for the measurement of antileucocidin levels suitable for routine use.…”

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confidence: 99%

Serological tests in the differentiation of staphylococcal and tuberculous bone disease.

Taylor¹,

Cook²,

Fincham³

et al. 1975

J Clin Pathol

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SYNOPSISThe haemagglutination test for antileucocidin is frequently positive in cases of bone tuberculosis in the absence of obvious staphylococcal infection. This test is therefore of little practical use in the differentiation of staphylococcal and tuberculous bone disease, and its use has been discontinued at the Royal National Orthopaedic Hospital.The antigamma haemolysin test in bone tuberculosis appears to give rise to few false positive results. Our observations confirm that the anti-alpha haemolysin and antigamma haemolysin tests used together reveal about 80% of cases of staphylococcal bone infection on first presentation or relapse.

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“…Staphylococcal infection is experienced by most of the population at some point in their lives, and raised agglutinin levels to Staph. aureus may be present in normal healthy persons (Towers and Gladstone, 1958;Quie and Wannamaker, 1964), although skin lesions and chronic staphylococcal infections may fail to produce a rise in antibody titre (Lack and Towers, 1962;Wilson and Miles, 1964), whereas acute illnesses, such as staphylococcal osteomyelitis, can give a sevenfold or greater increase in titre (Lack, 1957;Towers and Gladstone, 1958).…”

Section: Discussionmentioning

confidence: 99%

Agglutinin response to bacterial infection in acute exacerbations of chronic bronchitis.

Nicholls¹,

Pease²,

Green³

1975

J Clin Pathol

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syNopsIs Agglutinin titres to Haemophilus influenzae, Streptococcus pneumoniae, Klebsiella pneumoniae, Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli, and Proteus vulgaris in the serum of patients with acute exacerbations of chronic bronchitis, patients producing mucoid sputum, and healthy controls were determined. Serological evidence of infection with H. influenzae was found in 38 of 57 patients with acute exacerbations, and Str. pneumoniae infection in 10 of the 57 patients, but was generally absent from healthy control subjects and from patients producing mucoid sputum. No serological evidence of infection with other organisms named above was found to be associated with exacerbations of chronic bronchitis. Ten patients with acute exacerbations were without serological evidence of infection by any of the bacteria tested.Antibody response during chronic bronchitis was studied for the purpose of guidance in antibiotic therapy, since isolations of suspected microorganisms do not produce rapid or reliable information. The problem has been investigated by several workers, and, despite the complex antigenic structure of Haemophilus influenzae, most of the earlier workers agreed that bronchitic patients had specific antibodies to this bacterium in their serum, whereas control subjects had not (Faunce, 1958;Murdoch, Leckie, Downie, Swain, and Gould, 1959;Glynn, 1959). Wilson, Dunn, and Blair (1924), studying agglutinins to H. influenzae in the sera of patients suffering from influenza and other respiratory diseases, found that 208 of 220 control sera gave negative results while infected patients had titres above 1/80. These titres were seen to subside rapidly in convalescence. May (1965) found that agglutinins at high titre were commonest in patients with purulent sputum and rare in normal subjects. Burns and May (1968) found precipitins to Streptococcus pneumoniae. May (1965) found inconsistencies in the occurrence of agglutinins and precipitins to H. influenzae, whereas Jenne, MacDonald, Lapinski, Bratberg, and Hall (1970) found that precipitin and passive haemagglutination titres reflected acute infections and exacerbations although 'Present address:

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Serological Tests for Staphylococcal Infection

Cited by 42 publications

References 4 publications

The bacteriology of tropical pyomyositis in Uganda

The bacteriology of tropical pyomyositis in Uganda

Serological tests in the differentiation of staphylococcal and tuberculous bone disease.

Agglutinin response to bacterial infection in acute exacerbations of chronic bronchitis.

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