Serology of <i>Chlamydia pneumoniae</i> in patients with chronic cough

Kim, Woo Jin; Lee, Hui Young; Lee, Mi Eun; Lee, Seung-Joon

doi:10.1111/j.1440-1843.2006.00929.x

Cited by 5 publications

(4 citation statements)

References 20 publications

(42 reference statements)

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“…(2000), who used amoxicillin and erythromycin, this should have improved the performance of the trial therapy in culture negative patients since we thus covered more non‐mycobacterial pathogens, including ‘atypical’ agents such as Mycoplasma pneumoniae and Chlamydia pneumoniae , which are not covered by amoxicillin and can produce long episodes of cough (Vincent et al. 2000; Kim et al. 2006).…”

Section: Discussionmentioning

confidence: 99%

Performance of an algorithm based on WHO recommendations for the diagnosis of smear‐negative pulmonary tuberculosis in patients without HIV infection

Soto

Solari

Gotuzzo

et al. 2011

Tropical Med Int Health

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Summaryobjective To evaluate the performance of an algorithm based on WHO recommendations for diagnosis of smear-negative pulmonary tuberculosis in HIV-negative patients.methods We recruited HIV-negative patients with clinical suspicion of tuberculosis who had had three negative sputum smears in Lima, Peru. All included subjects underwent a complete anamnesis, physical examination and chest X-ray, and had a sputum specimen cultured in Ogawa, Middlebrook 7H9 media and MGITÒ. We applied an algorithm based on WHO recommendations to classify patients as having tuberculosis or not. The diagnostic performance of the algorithm was evaluated comparing its results against the reference standard of a positive culture for M. tuberculosis in either of the media used.results A total of 264 of the 285 patients included (92.6%) completed evaluation and follow up. Of these, 70 (26.5%) had a positive culture for M. tuberculosis. Clinical response to a broad spectrum course of antibiotics was good in 32 of these 70 patients (45.7; 95%CI 34.0-57.4%). Overall, the algorithm attained a sensitivity of 22.9% (95% CI 13.1-32.7%) and a specificity of 95.4 % (95% CI 92.4-98.3%) compared to culture results. The positive likelihood ratio was 4.93 and the negative likelihood ratio was 0.81.conclusions The sensitivity and negative likelihood ratio of the algorithm is poor. It should be reevaluated, and possibly adapted to local circumstances before further use. The clinical response to an antibiotic trial is the most important component to reassess. We also suggest considering performing chest X-ray earlier in the diagnostic work-up.

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Section: Discussionmentioning

confidence: 99%

Performance of an algorithm based on WHO recommendations for the diagnosis of smear‐negative pulmonary tuberculosis in patients without HIV infection

Soto

Solari

Gotuzzo

et al. 2011

Tropical Med Int Health

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“…In another study of 310 adolescent and adult patients with cough of 1- to 8-week duration (in Seoul and Incheon, 2009–2011), the pertussis positivity rate in culture, PCR, and serology tests was 1.0%, 3.2%, and 24.5%, respectively [70]. A case-control study found a positive association between acute Chlamydia pneumoniae infection and chronic cough [71]. However, in another study, only 1 of 68 patients with cough ≥3 weeks had a positive PCR for Chlamydia [42].…”

Section: Common Comorbidities In Adult Patients With Chronic Cough Inmentioning

confidence: 99%

Chronic cough in Korean adults: a literature review on common comorbidity

Kang

Kim

Song

et al. 2016

Asia Pacific Allergy

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Chronic cough is a significant medical condition with high prevalence and a strong negative impact on the quality of life. Cough hypersensitivity is thought to underlie chronic cough, with several environmental and host factors interacting to cause neuronal sensitization and chronicity. Comorbid conditions affecting cough reflex pathways, such as upper airway diseases, asthma, and gastroesophageal reflux, play important roles in chronic cough. However, their prevalence may vary in patients living in different geographical regions or with different ethnicities. We conducted a literature review to examine common comorbidities in Korean adult patients with chronic cough, their clinical implications, and the issues that still need to be addressed in the development of clinical evidence of chronic cough in Korean adult patients.

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“…In a case-control study, serological evidence of acute, but not chronic, infection of C. pneumoniae was more commonly found (25% vs. 5%) in 37 patients with chronic cough compared with agematched controls. 89 The journal also included two cases of recurrence of bronchiectasis after bilateral lung transplantation-a concern for future recipients. 90 Extending the use of Factor VIIa in haemophilia to a patient with diffuse alveolar haemorrhage from pulmonary-renal syndrome was demonstrated to be successful.…”

Section: Respiratory Infectionsmentioning

confidence: 99%