Seroma following breast cancer surgery

Pogson, Caroline; Adwani, Asha; Ebbs, S. R.

doi:10.1016/s0748-7983(03)00096-9

Cited by 176 publications

(162 citation statements)

References 54 publications

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“…Seroma is formed by acute inflammatory exudates in response to surgical trauma and acute phase of wound healing [4]. Oertli et al [5] believed that the fibrinolytic activity contribute to seroma formation.…”

Section: Pathogenesismentioning

confidence: 99%

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Seroma Formation after Mastectomy: Pathogenesis and Prevention

Sampathraju

Rodrigues

2010

Indian J Surg Oncol

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Post mastectomy seroma remains an unresolved quandary as the risk factors for its formation have still not been identified. Seromas of the axillary space following breast surgery can lead to significant morbidity and delay in the initiation of adjuvant therapy. Various techniques and their modifications have been practiced and published in English literature, but there seems to be no consensus. In this article, all aspects of seroma formation from pathogenesis to prevention including drug therapies have been discussed.

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Section: Pathogenesismentioning

confidence: 99%

“…It thus can lead to significant morbidity such as wound hematoma, delayed wound healing, wound infec-tion, wound dehiscence, prolonged hospitalization, delayed recovery and initiation of adjuvant therapy [4].…”

Section: Pathogenesismentioning

confidence: 99%

Seroma Formation after Mastectomy: Pathogenesis and Prevention

Sampathraju

Rodrigues

2010

Indian J Surg Oncol

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“…It has been proposed that the low fibrinogen levels and net fibrinolytic activity within lymphatic fluid collections account for seroma formation [23,24]. The closed spaces of lumpectomy cavities, axillary wounds, and the anterior chest wall cavity left under mastectomy skin flaps can all harbor seroma.…”

Section: Seromamentioning

confidence: 99%

“…Aspiration usually is well tolerated because the mastectomy and axillary incisions tend to be insensate; these procedures can be repeated as frequently as necessary to ensure that the skin flaps are densely adherent to the chest wall. Seroma aspiration is necessary in 10% to 80% of ALND and mastectomy cases, according to reported series and as reviewed in detail by Pogson and colleagues [23]. Axillary surgery limited to the sentinel lymph node biopsy seems to confer a lower risk of seroma formation, but this procedure usually is performed without drain insertion; therefore occasional patients require subsequent seroma aspiration [25].…”

Section: Seromamentioning

confidence: 99%

“…The tissue effects of electrocautery are a well-recognized risk factor for increased seroma formation [23]. Two prospective clinical trials have randomly assigned patients who have breast cancer to undergo surgery with electrocautery or with scalpel only and have confirmed the lower incidence of seroma formation with the latter technique [32,33].…”

Section: Seromamentioning

confidence: 99%

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Complications in Breast Surgery

Vitug

Newman

2007

Surgical Clinics of North America

156

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The breast is a relatively clean organ comprised of skin, fatty tissue, and mammary glandular elements that have no direct connection to any major body cavity or visceral structures. In the absence of concurrent major reconstruction, breast surgery generally is not accompanied by large-scale fluid shifts, infectious complications, or hemorrhage. Thus, most breast operations are categorized as low-morbidity procedures. Because the breast is the site of the most common cancer afflicting American women, however, a variety of complications can occur in association with diagnostic and multidisciplinary management procedures. Some of these complications are related to the breast itself, and others are associated with axillary staging procedures. This article first addresses some general, nonspecific complications (wound infections, seroma formation, hematoma). It then discusses complications that are specific to particular breast-related procedures: lumpectomy (including both diagnostic open biopsy and breast-conservation therapy for cancer), mastectomy; axillary lymph node dissection (ALND), lymphatic mapping/sentinel lymph node biopsy, and reconstruction. Complications related to reconstruction are discussed in a separate article in this issue. General wound complications related to breast and axillary surgeryBecause it is a peripheral soft tissue organ, many wound complications related to breast procedures are relatively minor and frequently are managed on an outpatient basis. It therefore is difficult to establish accurate incidence rates for these events. As discussed later, however, reported studies

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