Seroma Formation in Pre-pectoral Implant-Based ADM Assisted Breast Reconstruction: A Comprehensive Review of Current Literature

Caputo, Glenda Giorgia; Mura, Sebastiano; Albanese, Roberta; Zingaretti, Nicola; Parodi, Pier Camillo

doi:10.21614/chirurgia.116.2suppl.s16

Cited by 13 publications

(23 citation statements)

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“…Moreover, early experiences with suboptimally processed cadaveric ADMs and xenogeneic matrices with added chemicals showed that such products could irritate tissues and cause an increased exudate production ( 5 , 21 ). Indeed, although an older review reports a higher rate of seroma formation with ADM compared to a completely submuscular expander, an up-to-date review by Caputo et al finds no increment in seroma formation with the use of BRAXON® and proposes operative strategies to improve outcomes further ( 17 , 21 ). Similarly, more recent data on PPBR performed with human ADMs on 2,270 breasts confirmed the low rate of seroma formation (4.8%) ( 22 ).…”

Section: Discussionmentioning

confidence: 99%

“…Seroma 0 (0) 1 (3. and proposes operative strategies to improve outcomes further (17,21). Similarly, more recent data on PPBR performed with human ADMs on 2,270 breasts confirmed the low rate of seroma formation (4.8%) (22).…”

Section: Complications Major Minormentioning

confidence: 99%

“…The breast implant wrapping ease allowed by the precut shape of BRAXON® ADM might have contributed to rendering it the most studied biological matrix for PPBR ( 17 ). In 2021, BRAXON® has been released in the new format BRAXON® Fast (DECOMED, Venezia, Italy).…”

Section: Introductionmentioning

confidence: 99%

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Novel three-dimensional acellular dermal matrix for prepectoral breast reconstruction: First year in review with BRAXON®Fast

Berna

Grazia²,

Antoniazzi³

et al. 2022

Front. Surg.

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Implant-based breast reconstruction is part of breast cancer treatment, and increasingly optimized reconstructive procedures exploit highly biocompatible materials to ensure enhanced aesthetic-functional results. Acellular dermal matrices (ADMs) are collagen-based materials that made prepectoral implant placement possible, thanks to their bioactive antifibrosis action. Recently, the first three-dimensional ADM, BRAXON®Fast, has been produced. Its 3D design represents the technological evolution of BRAXON® ADM, a flat collagen matrix, and allows for a time-saving complete wrapping of the synthetic prosthesis, thus creating a total biological interface on the implant with patient's tissues. Here, we report our experience on the first 23 eligible patients who received BRAXON®Fast-assisted prepectoral reconstruction. On a total of 27 breasts, the overall complication rate was 11.1%, including one minor seroma (3.7%), one case of necrosis (3.7%), and one implant removal due to infection. As new-generation devices, 3D ADMs showed an effective performance, allowing to reduce the overall exposure time for implant preparation and providing an optimal safety profile.

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Section: Discussionmentioning

confidence: 99%

Section: Complications Major Minormentioning

confidence: 99%

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Novel three-dimensional acellular dermal matrix for prepectoral breast reconstruction: First year in review with BRAXON®Fast

Berna

Grazia²,

Antoniazzi³

et al. 2022

Front. Surg.

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“…This confirms that the technical characteristics of the implanted material inevitably influence the clinical result (93), be it biological or synthetic. Together with the technical specificity of the material, however, the clinical evidence analyzed here suggests seroma as a side effect of surgery rather than a complication of breast reconstruction (44,111). In particular, there are three elements that contribute predominantly to fluid accumulation, namely (i) destruction of the lymphatic vessels, (ii) inflammatory fluids, and (iii) presence of dead spaces (44).…”

Section: Why Then Do We Perform Prepectoral Reconstruction Surgeries ...mentioning

confidence: 84%

“…This was also testified by Berna et al comparing the Braxon® seroma results with those of a previous additive version of Braxon® (25). However, this hypothesis would support an inflammatory origin of the seroma complication, which, even today, is often regarded as etiologically orphaned (44). A reference that helps to clarify this issue is a publication dated 2015, where it was investigated whether the presence of ADMs influenced the daily postoperative serum collection pattern (127).…”

Section: Why Then Do We Perform Prepectoral Reconstruction Surgeries ...mentioning

confidence: 99%

Braxon®-assisted prepectoral breast reconstruction: A decade later

et al. 2022

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We are sitting on the cusp of the bioengineered breast era, in which implant-based breast reconstruction is seeing a growing trend and biotechnology research progressively empowers clinical practice. As never before, the choice of biomaterials has acquired great importance for achieving reconstructive outcomes, and the increase in the use of acellular dermal matrices (ADMs) in the field of senology tells us a story of profound upheaval and progress. With the advent of prepectoral breast reconstruction (PPBR), plenty of devices have been proposed to wrap the silicone prosthesis, either completely or partially. However, this has caused a great deal of confusion and dissent with regard to the adoption of feasible reconstructive strategies as well as the original scientific rationale underlying the prepectoral approach. Braxon® is the very first device that made prepectoral implant positioning possible, wrapping around the prosthesis and exerting the proven ADM regenerative potential at the implant–tissue interface, taking advantage of the body's physiological healing mechanisms. To date, the Braxon® method is among the most studied and practiced worldwide, and more than 50 publications confirm the superior performance of the device in the most varied clinical scenarios. However, a comprehensive record of the working of this pioneering device is still missing. Therefore, our aim with this review is to lay a structured knowledge of surgery with BRAXON® and to provide a decision-making tool in the field of PPBR through a complete understanding on the very first device for prepectoral, one decade after its introduction.

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Prepectoral Implant-Based Breast Reconstruction with Anterior Implant Coverage

Reitsamer

Sir

2023

Prepectoral Breast Reconstruction

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Seroma Formation in Pre-pectoral Implant-Based ADM Assisted Breast Reconstruction: A Comprehensive Review of Current Literature

Cited by 13 publications

References 0 publications

Novel three-dimensional acellular dermal matrix for prepectoral breast reconstruction: First year in review with BRAXON®Fast

Novel three-dimensional acellular dermal matrix for prepectoral breast reconstruction: First year in review with BRAXON®Fast

Braxon®-assisted prepectoral breast reconstruction: A decade later

Prepectoral Implant-Based Breast Reconstruction with Anterior Implant Coverage

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