Seromucinous ovarian tumor A comparison with the rest of ovarian epithelial tumors

Karpathiou, Georgia; Chauleur, Céline; Corsini, Thomas; Venet, Melany; Habougit, Cyril; Honeyman, Freschia; Forest, Fabien; Péoc’h, Michel

doi:10.1016/j.anndiagpath.2017.01.002

Cited by 26 publications

(24 citation statements)

References 10 publications

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“…A characteristic feature of mucinous ovarian tumor is the presence of a morphological continuum with benign, borderline and malignant lesions occurring simultaneously. This tumor heterogeneity is thought to reflect the nature of its biological progression . Ovarian IECA, which is the equivalence of an ovarian precancerous lesion or an ovarian carcinoma in situ, is thought to be a transitional stage in the process of malignant transformation from MBOTs to mucinous carcinoma.…”

Section: Discussionmentioning

confidence: 99%

“…This tumor heterogeneity is thought to reflect the nature of its biological progression. 9,10 Ovarian IECA, which is the equivalence of an ovarian precancerous lesion or an ovarian carcinoma in situ, is thought to be a transitional stage in the process of malignant transformation from MBOTs to mucinous carcinoma. However, the clinical prognoses of these diseases are greatly different.…”

Section: Discussionmentioning

confidence: 99%

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Mucinous borderline ovarian tumors with and without Intraepithelial Carcinoma: Differences in clinicopathologic features and fertility results

Chen

Tao

et al. 2020

J of Obstet and Gynaecol

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Aim To investigate the clinicopathologic characteristic and fertility results of patients with mucinous borderline ovarian tumors (MBOTs), and the effects of intraepithelial carcinoma (IECA) on them. Methods Fifty‐two patients treated for MBOTs with or without IECA were retrospectively analyzed. Results Patients with IECA were more frequently observed at stage Ic (3/12 vs 1/40, P = 0.034) and accompanied by microinvasive carcinoma (3/12 vs 1/40, P = 0.034). The detected rate of IECA by intraoperative frozen section (5/12, 41.7%) was much lower than that of MBOTs (82.5%, P = 0.010). About 61.5% patients in our study underwent fertility‐sparing surgery. Follow‐up information was retained completely in 41 patients. And all four tumor recurrences were observed (9.8%) in conservative surgery group in 66 months, though there was no statistical association (P = 0.280). There were three patients who recurred more than once, even one occurred tumor‐related death. Only one recurrent patient was in IECA group (P > 0.05). However, patients with IECA were more likely to receive adjuvant chemotherapy (3 of 12 vs 0 of 40, P = 0.010) and surgical staging (75% vs 52.5%, P = 0.200). As for fertility results, nine patients wished to be pregnant and seven of them (77.8%) were successful. Conclusion For young patients with MBOTs, fertility results are satisfactory after conservative surgery. But patients should be fully informed about the relative high recurrent rate. And IECA has no statistical negative effects on MBOTs till now, but a long‐term follow‐up is required.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Mucinous borderline ovarian tumors with and without Intraepithelial Carcinoma: Differences in clinicopathologic features and fertility results

Chen

Tao

et al. 2020

J of Obstet and Gynaecol

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“…Due to limited experience, the small number of reported cases, and possible inter-observer variability on diagnosis (as mentioned below), the exact incidence and prognosis of SMCA are unclear. One study found SMCA comprised 4% (6/149 cases) of all ovarian carcinomas, with lower 5-year survival (55%) than for clear cell carcinoma (75%); however, the difference was not statistically significant [22].…”

Section: Seromucinous Carcinomamentioning

confidence: 98%

“…Seromucinous carcinoma (SMCA) is relatively rare; fewer than 40 cases have been described in the English literature, and no stage IV disease has been reported yet [20][21][22]. SMCA shares gross and microscopic features with SMBT ( Figure 5), demonstrating papillary projections resembling those of SBT and admixture of several müllerian cell types, and shows high-grade cytologic atypia and architectural complexity.…”

Section: Seromucinous Carcinomamentioning

confidence: 99%

Ovarian Seromucinous Tumors: Pathogenesis, Morphologic Spectrum, and Clinical Issues

Nagamine

Mikami

2020

Diagnostics

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Ovarian seromucinous tumors were introduced in the 2014 World Health Organization (WHO) classification as one of the seven types of ovarian epithelial tumors. They are characterized by frequent association with endometriosis and bilaterality, microscopic appearance of papillary architecture, and admixture of a variety of müllerian-type epithelium. They are considered to be endometriosis-related ovarian neoplasms, along with endometrioid and clear cell tumors; recent molecular studies suggest this particular tumor is a variant of endometrioid tumor. Discrepancies in nomenclature, definition, and morphology of seromucinous tumors appear to be a source of confusion, for both clinicians and general surgicalpathologists. This review summarizes the clinicopathological features of benign, borderline, and malignant seromucinous tumors, as well as controversies regarding these tumors.

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“…The revealed morphological features of borderline SMT and seromucinous carcinoma are similar to the literature data. Shappell et al [20] have studied the clinical morphological features of borderline SMT in 34 women, intraepithelial carcinoma in 5 patients, microinvasive carcinoma with stromal invasion less than 5 mm in 7 patients, and carcinoma in 8 women. They found a characteristic papillary structure resembling serous tumors and heterogeneity of the epithelial cells population, including not only serous (ciliated) and endocervical, but also endometrioid, clear-cell and undifferentiated cells with eosinophilic cytoplasm.…”

Section: оригинальные статьиmentioning

confidence: 99%

Seromucinous ovarian tumors and endometriosis in reproductive-aged wo

Shamarakova¹,

Adamyan²,

Asaturova³

et al. 2018

Akusherstvo i ginekologiia

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Endometriosis affects up to 15% of reproductive-aged women. Consideration of this nosological entity in a new aspect is impelled by the evidence that 0.5-1% of cases are complicated by endometriosis-associated ovarian neoplasms represented mainly by the endometrioid and clear-cell subtypes of tumors. This category also includes seromucinous ovarian tumors (SMOTs). Objective. To investigate the morphological and immunohistochemical (IHC) features of SMOTs in reproductiveaged women, including pregnant ones. Subjects and methods. Ovarian tumor samples from 15 patients who had been operated on in 2012-2016 were analyzed comprehensively at the National Medical Research Center of Obstetrics, Gynecology, and Perinatology: IHC examination was conducted using the biomarkers of estrogen and progesterone receptors and Ki-67. Results. Borderline SMOTs were characterized by papillary growths on the inner surface (in one case) and on the outer surface, with an adhesive process with the serous surface of the corpus uteri (FIGO Stage 1c), and mixed epithelial structures; leukocyte infiltration was observed in four cases. The epithelium of seromucinous carcinoma (n = 1) was similar to that of serous, endocervical, and endometrial types at the same time. All the samples exhibited low Ki-67 expression and high positive receptor immunoreactivity. Endometriosis diagnosed in nine women was accompanied by benign seromucinous cystadenomas (n = 4), borderline tumors (n = 4), and carcinoma (n = 1). Conclusion. Most of the examined SMOTs showed the areas, covered with the endometrioid epithelium, with adjacent endometrial stroma, which indicated the development of carcinoma in the presence of endometrioid cyst. The revealed facts suggest that endometriosis plays an etiological role in developing SMOTs. When detected, most neoplasms are localized (limited to ovarian tissue, FIGO stage 1a) and characterized by a favorable prognosis as a whole.

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Seromucinous ovarian tumor A comparison with the rest of ovarian epithelial tumors

Cited by 26 publications

References 10 publications

Mucinous borderline ovarian tumors with and without Intraepithelial Carcinoma: Differences in clinicopathologic features and fertility results

Mucinous borderline ovarian tumors with and without Intraepithelial Carcinoma: Differences in clinicopathologic features and fertility results

Ovarian Seromucinous Tumors: Pathogenesis, Morphologic Spectrum, and Clinical Issues

Seromucinous ovarian tumors and endometriosis in reproductive-aged wo

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