Seronegative Spondyloarthropathies: Evolving Concepts Regarding Diagnosis and Treatment

Papagoras, Charalampos; Drosos, Alexandros A.

doi:10.4172/2165-7939.1000e102

Cited by 4 publications

(7 citation statements)

References 45 publications

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“…The absence of rheumatoid factor was the basis for the Spa group being labeled 'seronegative'although this is no longer used. 5 Anterior uveitis is the most common extra-articular manifestation of AS. [6][7][8] About one-third of the patients with AS have one or more episodes of anterior uveitis.…”

Section: Hla-b27-related Disordersmentioning

confidence: 99%

Biologic Therapy for HLA-B27-associated Ocular Disorders

Gueudry

Thorne

Bansie

et al. 2016

Ocular Immunology and Inflammation

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The treatment of articular and extra-articular manifestations associated with HLA-B27 has undergone dramatic changes over the past two decades, mainly as a consequence of the introduction of biologic agents and in particular anti-tumor necrosis factor α (anti-TNFα) agents. Uveitis is known to be the most frequent extra-articular feature in HLA-B27-associated spondyloarthritides. Topical corticosteroids and cycloplegic agents remain the cornerstones of treatment. However, biologic therapy may be effective in the management of refractory or recurrent forms of uveitis. This review gives an update on the management of HLA-B27-associated ocular disorders with biologics, including anti-TNFα agents and non-anti-TNFα biologic modifier drugs. There is an emerging role for newer biologics targeting interleukin-12/23 and interleukin-17 for the treatment of spondyloarthritides but data on their efficacy on anterior uveitis are sparse.

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Section: Hla-b27-related Disordersmentioning

confidence: 99%

Biologic Therapy for HLA-B27-associated Ocular Disorders

Gueudry

Thorne

Bansie

et al. 2016

Ocular Immunology and Inflammation

View full text Add to dashboard Cite

show abstract

“…In RA, there is symmetrical involvement of the joints of the hands and feet accompanied by the presence of erosions and absence of new bone apposition. Auto-antibodies such as rheumatoid factor (RF) and anti-citrullinated peptide antibody (anti CCOP) are often present in RA [14]. On the other hand, SpA is characterised by human leukocyte antigen (HLA)-B27 association, and asymmetrical, oligoarticular peripheral arthritis that predominantly occurs in the lower extremities.…”

Section: Spondyloarthritismentioning

confidence: 99%

“…On the other hand, SpA is characterised by human leukocyte antigen (HLA)-B27 association, and asymmetrical, oligoarticular peripheral arthritis that predominantly occurs in the lower extremities. Other features that link the SpA group of diseases include sacroiliitis, spondylitis, dactylitis, enthesitis and an increased susceptibility for inflammatory eye disease [14,28].…”

Section: Spondyloarthritismentioning

confidence: 99%

“…Non-steroidal anti-inflammatory drugs (NSAIDs) remain [13][14][15]. Other supportive measures that play an important role in the management of SpA include patient education and exercise [41,42], as well as physical therapy, rehabilitation, surgical referrals, patient associations and self-help groups [41].…”

Section: Spondyloarthritismentioning

confidence: 99%

“…These diseases share various common features in their clinical presentation, as well as pathophysiology. To date, its classification [1][2][3], epidemiology [4][5][6], pathogenesis [7][8][9][10][11][12] and treatment [13][14][15] have been reviewed extensively in the published literature. In addition, there is an increasing interest and an expanding body of research concerning the use of stem cells of various origins in the treatment of autoimmune diseases including SpA.…”

Section: Introductionmentioning

confidence: 99%

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