Seronegative spondyloarthropathies in Greece: a population-based study of prevalence, clinical pattern, and management. The ESORDIG study

Abstract

The objective of this study was to determine the prevalence, clinical pattern, and management of seronegative spondyloarthropathies (SpA) in the general adult population of Greece. This population-based study was conducted on a target adult (> or =19-year-old) population of 14,233 subjects by rheumatologists who visited households in nine dispersed areas. An interview (standardized questionnaire) was conducted, clinical evaluation and laboratory investigation were done, and established diagnostic classification criteria were used. The age-adjusted and sex-adjusted prevalence (prevalence(asa)) of SpA was 0.49% [95% confidence interval (CI): 0.38-0.60], with a male to female ratio of 5.5:1; the prevalence increased with age until the 59- to 68-year-old age group and declined thereafter. The prevalence(asa) of ankylosing spondylitis (AS) and psoriatic arthritis (PsA) was 0.24% (95% CI: 0.16-0.32) and 0.17% (95% CI: 0.10-0.24), respectively. The mean age (years) at onset was younger in AS (25.83 +/- 6.5) than in PsA (45.24 +/- 12.94) (p < 0.01). Familial clustering was noticed in 5.3% of AS probands. Sacroiliitis was observed in 39.8% and asymmetrical oligoarthritis in 40.6% of PsA patients. Fifty-nine percent of SpA patients had previously visited rheumatologists (91.3% diagnosed correctly vs 11.6% of those who visited other specialists, p < 0.0005); 56.5% of the former had taken disease-modifying antirheumatic drugs compared to none of the latter. The SpA in Greeks are as common as in other European Caucasians, with a high male preponderance. The PsA onset occurs at an older age than AS and frequently presents with a spondylitic pattern. The correct diagnosis was arrived at and appropriate treatment was given when patients consulted rheumatologists.

The prevalences of some rheumatic diseases in western Turkey: Havsa study

“…The diagnostic criteria we used allow the inclusion of both active and inactive cases. Although Table 3 The results of HLA-B27 and HLA-B51 in the studied population and comparison the results in the other regions in our country (% frequencies) Pirim (121) Uyar ( [40,[72][73][74] 0-0.8 [75] 0.06-0.54 [46-48, 54, 76] 0.1-6.3 [60,75] 0.49 [12] 0.120 0.114-0.126 IBD 0.20-0.42 [77,78] 0.31 [79] 0.16 [80] 0.3-0.5 [81][82][83] 0.035 0.032-0.037 Ps 1.17-4.20 [84][85][86][87][88] 0.67 [56,89] 0.424 0.414-0.434…”

Axial disease in psoriatic arthritis

“…Three population-based studies reported on the prevalence of spondyloarthritis including PsA in the past 3 years [10][11][12]. In Greece, Trontzas et al [10] clinically assessed 10,647 individuals. Using the ESSG criteria, they estimated the prevalence of PsA in Greece to be 0.17%.…”

Epidemiology of Psoriasis and Psoriatic Arthritis

“…Data were not population-based, for they were obtained by examining diagnoses among rheumatology hospitals and private rheumatologists. In another study evaluating, on a population base, the prevalence of seronegative spondyloarthropaties in different geographical areas of Greece, a prevalence of 0.17% was shown (27). The prevalence was higher in men and in the age class between 49 and 68 years.…”