Seroprevalance of Human Parvovirus B19 among Blood Donor Volunteers from Sudanese Blood Bank in Khartoum State 2017

Omer, Amasi Hassan; Adam, Ayat Jamal Al-deen; Mohamed, Fatima Ali; Hamed, Fatima Hashim; Edr, Haram Hussain; Al-sedig, Marwa Ahmed; Ahmed, Romisa Hashim; Mohammed, Yoonis Ismail; Hamid, Omnia

doi:10.4172/2476-1966.1000127

Cited by 1 publication

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“…Our B19V IgG antibody seroprevalence in blood donors was lower compared with those in Belgium (74%) [ 58 ], Makkah (76.3%) [ 65 ], and Italy (79.1%) [ 66 ]. Conversely, seroprevalence was higher than in studies of blood donors in India (39.97%) [ 67 ], China (16.8%) [ 68 ], Egypt (26%) [ 59 ], Yemen (46%), Iran (27.6%) [ 69 ], and Pune (27.9%) [ 60 ]. This could be due to the variations in age distribution among the study groups, socioeconomic status, the size and demographic characteristics of the study populations, the diagnostic techniques, and seasonal timing differences, since the infection peaks predominantly during late winter and early spring [ 70 ].…”

Section: Discussionmentioning

confidence: 75%

“…This could be attributed to the fact that our study population was mostly composed of expatriates from the same age group. The lack of correlation between B19V seroprevalence and age has also been reported from studies in Egypt [ 76 ], Nigeria [ 77 ] and Sudan [ 59 ]; however, all these studies had relatively small sample sizes (≤ 180). We observed comparable seropositivity rates of B19V IgG among different age groups, with the 31–40 age group exhibiting the lowest seropositivity rate (60.6%).…”

Section: Discussionmentioning

confidence: 76%

“…Overall, there was a significant difference ( p = 0.0449) in B19V IgG seroprevalence between male and female blood donors. Similarly, various studies performed in Taiwan, the United States, Brazil, and Sudan, showed gender differences in the prevalence [ 59 , 71 , 72 , 73 ]. In contrast, other studies conducted in Brazil and Australia showed no gender differences in the prevalence [ 74 , 75 ].…”

Section: Discussionmentioning

confidence: 87%

“…This seroprevalence is comparable with previous estimates reported worldwide and in the MENA region. For instance, two studies in Tunisia and Sudan reported a B19V IgG seroprevalence of 65% and 63.3% in blood donors, respectively [ 58 , 59 ]. In North India, a study of volunteer blood donors reported a seroprevalence of 61.8% of B19V IgG antibodies [ 60 ].…”

Section: Discussionmentioning

confidence: 99%

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Prevalence and Phylogenetic Analysis of Parvovirus (B19V) among Blood Donors with Different Nationalities Residing in Qatar

Abdelrahman

Al-Sadeq

Smatti

et al. 2021

Viruses

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Human parvovirus (B19V) is the causative agent of erythema infectiosum in children and is linked to a wide range of clinical manifestations. Studies related to B19V prevalence in the Middle East and North Africa (MENA) region and other parts of Asia are very scarce. The objectives of this study were to estimate the seroprevalence (anti-B19V IgM and IgG), the viremia rate (B19V DNA), and the circulating genotypes of B19V among blood donors in Qatar. Methods: Donors’ blood samples (n = 5026) from different nationalities, mainly from the MENA region and South East Asia, were collected from 2014–2016. Samples were tested for the B19V DNA using RT-PCR. Furthermore, 1000 selected samples were tested to determine the seroprevalence of B19V antibodies using enzyme-linked immunosorbent assay (ELISA). Genotyping was performed on 65 DNA positive samples by sequencing of nested PCR fragments (NS1-VP1u region, 927 nt). Results: Only 1.4% (70/5026) of the samples had detectible B19V DNA in their blood. B19V DNA prevalence statistically decreased with age (p = 0.03). Anti-B19V IgG was detected in 60.3% (561/930) of the tested samples, while only 2.1% (20/930) were IgM-positive and 1.2% (11/930) were both IgM- and IgG-positive. B19V genotyping showed a predominance of Genotype 1 (100%). Sequence analysis of the NS1-VP1u region revealed 139 mutation sites, some of which were amino acid substitutions. Conclusion: Our results indicated a relatively high seroprevalence of B19V in Qatar. Most importantly, B19 DNA was detected among Qatari and non-Qatari blood donors. Therefore, blood banks in Qatar might need to consider screening for B19V, especially when transfusion is intended for high-risk populations, including immunocompromised patients.

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