Seroprevalence and epidemiological characteristics of HDV infection among HBV patients in the Nile Delta, Egypt

El-Zefzafy, Wafaa M.; Soliman, Reham; Saleh, Layla M.; Mahmoud, Safyia; Makhlouf, Nahed A; Shiha, Gamal; Zaky, Samy

doi:10.1111/jvh.13621

Cited by 3 publications

(2 citation statements)

References 7 publications

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“…2 Similar to the authors' findings in other Middle East countries, other studies published in the last 10 years from Egypt showed variable prevalence among HBsAg-positive patients: 4.7% seroprevalence among 170 patients in Ismailia (a state in Eastern Egypt along the Suez Canal), 3 9.9% viremic prevalence among 121 patients in Cairo, 4 and 3.4% seroprevalence and 1.27% viremic prevalence among 631 patients in the Nile delta states. 5 This confirms the author's findings of lack of quality data and confirms their call for a need for "more precise data" and national surveys to highlight the magnitude of the problem and assess current and future therapy needs.…”

Section: E T T E R T O T H E E D I T O R Hepatitis Delta Virus Infect...supporting

confidence: 69%

Hepatitis delta virus infection in the Middle East

Waked¹

2022

Liver International

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Section: E T T E R T O T H E E D I T O R Hepatitis Delta Virus Infect...supporting

confidence: 69%

Hepatitis delta virus infection in the Middle East

Waked¹

2022

Liver International

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“…27 However, the prevalence of HCC among people co-infected with HBV and HDV was comparable, ranging from 8.8% to 13.6%. 27,28 International and local studies suggest that a family history of liver cancer is a significant risk factor for HCC development. 29,30 A study by Velazquez reported that the risk of developing HCC in cirrhotic patients above 54 years of age is four times higher than that in younger patients.…”

mentioning

confidence: 99%

Egyptian Society of Liver Cancer Recommendation Guidelines for the Management of Hepatocellular Carcinoma

Omar,

Kaseb,

Elbaz

et al. 2023

JHC

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Globally, hepatocellular carcinoma (HCC) is the fourth most common cause of death from cancer. The prevalence of this pathology, which has been on the rise in the last 30 years, has been predicted to continue increasing. HCC is the most common cause of cancer-related morbidity and mortality in Egypt and is also the most common cancer in males. Chronic liver diseases, including chronic hepatitis C, which is a primary health concern in Egypt, are considered major risk factors for HCC. However, HCC surveillance is recommended for patients with chronic hepatitis B virus (HBV) and liver cirrhosis; those above 40 with HBV but without cirrhosis; individuals with hepatitis D co-infection or a family history of HCC; and Nonalcoholic fatty liver disease (NAFLD) patients exhibiting significant fibrosis or cirrhosis. Several international guidelines aid physicians in the management of HCC. However, the availability and cost of diagnostic modalities and treatment options vary from one country to another. Therefore, the current guidelines aim to standardize the management of HCC in Egypt. The recommendations presented in this report represent the current management strategy at HCC treatment centers in Egypt. Recommendations were developed by an expert panel consisting of hepatologists, oncologists, gastroenterologists, surgeons, pathologists, and radiologists working under the umbrella of the Egyptian Society of Liver Cancer. The recommendations, which are based on the currently available local diagnostic aids and treatments in the country, include recommendations for future prospects.

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Prevalence and Impact of HBV and HDV Infection Globally and in MENA Region

A. Makhlouf

2024

Hepatitis B Virus - Pathogenesis and Therapeutic Approaches [Working Title]

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Globally, hepatitis B virus (HBV) infection is a major global health problem, with an estimated 296 million infections worldwide, and about 5% of them had hepatitis delta virus (HDV) infection as well. Hepatitis D virus (HDV) infection is endemic in the Middle East. Hepatitis D virus (HDV) infection has been considered a serious neglected pandemic, particularly in developing Countries. Combined HDV-HBV infection produces more severe liver affection than HBV alone. Effect varies between coinfection and superinfection. In this book chapter, we will highlight four main points. Firstly, the prevalence of hepatitis D virus infection among HBsAg positive individuals globally and in MENA Region (Middle EAST and North Africa); secondly, the clinical, laboratory, and virological characters of HDV infected patients; thirdly, the need for improving the laboratory diagnostic tests and initiating patient data registries and blood screening; and lastly, the efficacy of new drugs for chronic hepatitis D on coinfected patients.

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Seroprevalence and epidemiological characteristics of HDV infection among HBV patients in the Nile Delta, Egypt

Cited by 3 publications

References 7 publications

Hepatitis delta virus infection in the Middle East

Hepatitis delta virus infection in the Middle East

Egyptian Society of Liver Cancer Recommendation Guidelines for the Management of Hepatocellular Carcinoma

Prevalence and Impact of HBV and HDV Infection Globally and in MENA Region

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