Seroprevalence and genotyping of hepatitis C virus in multiple transfused Jordanian patients with β-thalassemia major

Al‐Sweedan, Suleimman; Jaradat, Said; Amer, Khitam; Hayajneh, Wail A.; Haddad, Hazem

doi:10.5152/tjh.2011.05

Cited by 12 publications

(10 citation statements)

References 19 publications

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“…In another study, most of the HCV infected patients younger than 45 years had genotype 3a, and other genotypes were seen in those older than 45 years. The increased prevalence of 3a patients in this study is in accordance with the above-mentioned studies (28).…”

Section: Discussionsupporting

confidence: 93%

Prevalence and Risk Factors of Hepatitis C Infection (HCV) in Birjand, Iran, 2014

et al. 2016

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Background: Hepatitis C virus (HCV) infection is an important global concern, with a frequency of 3% (i.e., 170 million of the population has HCV-Ab). Additionally, 50% of HCV and 80% of transfusion transmitted infections (TTI) are chronic. In 20% of cases, HCV occurs as an acute infection, and in the remaining 80% of cases, it becomes chronic. In chronic patients, risk of cirrhosis is up to 44%, risk of hepatocellular carcinoma (HCC) is 13%, and risk of mortality is 14%. As there is no vaccine available for the virus yet, and since most of the cases are asymptomatic, attention to the epidemiology of the disease among the population is a pressing concern. Objectives: The aim of this study is to determine the prevalence and risk factors of HCV in Birjand city. Patients and Methods:In this descriptive-analytical study, 5,235 people who live in Birjand city were selected; after gaining permission for the study, a signed consent form was obtained from each patient. Prevalence of HCV was determined by ELISA test, and positive cases underwent Polymerase chain reaction (PCR) and genotyping for confirmation. Results: The mean age of the participants was 39.7 ± 14.4. Among them, 52.2% were female and 29.9% had university degrees. Prevalence of HCV-Ab + was about 0.2% with ELISA, and 0.14% of entire group were confirmed by PCR. No significant relationship was found for age, sex, and education (P > 0.05). Also, there was no significant relationship found with risk factors such as endoscopy, blood transfusion, surgery, hospitalization, phlebotomy, and alcohol drinking (P > 0.05). HCV-Ab was 200 times more prevalent in IV-drug abusers compared to nonaddicted people. Also, the prevalence of HCV-Ab in non-IV-drug abuser addicts was 9.3 times higher than in non-addict patients. Prevalence of HCV-Ab in patients who reported illicit sexual activities was 13.3 times higher. In patients with a familial history of HCV, infection was 26.3 times more prevalent than in patients with no familial history (P < 0.001). Conclusions: In this study, the prevalence of HCV was 0.2%, which is lower than the mean prevalence in Iran (1%). Prevalence of HCV had a significant relationship with IV-drug abuse.

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Section: Discussionsupporting

confidence: 93%

Prevalence and Risk Factors of Hepatitis C Infection (HCV) in Birjand, Iran, 2014

et al. 2016

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“…Among populations at high risk ( Table 2 ), high HCV prevalence levels ranging from 21% to 49.8% were observed among hemodialysis patients. A prevalence of 32.8% was also observed among thalassemic patients [ 68 ].…”

Section: Resultsmentioning

confidence: 99%

The Epidemiology of Hepatitis C Virus in the Fertile Crescent: Systematic Review and Meta-Analysis

2015

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ObjectiveTo characterize hepatitis C virus (HCV) epidemiology in countries of the Fertile Crescent region of the Middle East and North Africa (MENA), namely Iraq, Jordan, Lebanon, Palestine, and Syria.MethodsWe systematically reviewed and synthesized available records of HCV incidence and prevalence following PRISMA guidelines. Meta-analyses were implemented using a DerSimonian-Laird random effects model with inverse weighting to estimate the country-specific HCV prevalence among the various at risk population groups.ResultsWe identified eight HCV incidence and 240 HCV prevalence measures in the Fertile Crescent. HCV sero-conversion risk among hemodialysis patients was 9.2% in Jordan and 40.3% in Iraq, and ranged between 0% and 3.5% among other populations in Iraq over different follow-up times. Our meta-analyses estimated HCV prevalence among the general population at 0.2% in Iraq (range: 0–7.2%; 95% CI: 0.1–0.3%), 0.3% in Jordan (range: 0–2.0%; 95% CI: 0.1–0.5%), 0.2% in Lebanon (range: 0–3.4%; 95% CI: 0.1–0.3%), 0.2% in Palestine (range: 0–9.0%; 95% CI: 0.2–0.3%), and 0.4% in Syria (range: 0.3–0.9%; 95% CI: 0.4–0.5%). Among populations at high risk, HCV prevalence was estimated at 19.5% in Iraq (range: 0–67.3%; 95% CI: 14.9–24.5%), 37.0% in Jordan (range: 21–59.5%; 95% CI: 29.3–45.0%), 14.5% in Lebanon (range: 0–52.8%; 95% CI: 5.6–26.5%), and 47.4% in Syria (range: 21.0–75.0%; 95% CI: 32.5–62.5%). Genotypes 4 and 1 appear to be the dominant circulating strains.ConclusionsHCV prevalence in the population at large appears to be below 1%, lower than that in other MENA sub-regions, and tending towards the lower end of the global range. However, there is evidence for ongoing HCV transmission within medical facilities and among people who inject drugs (PWID). Migration dynamics appear to have played a role in determining the circulating genotypes. HCV prevention efforts should be targeted, and focus on infection control in clinical settings and harm reduction among PWID.

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“…This rate was much higher than voluntary blood donors in Iran (4). In 2007, the prevalence of hepatitis C infection in patients with thalassemia in Iran was reported 15.7% to 63.8% (9); while it was 32% among patients with thalassemia in Jordan in 2009 (10). Two studies were conducted on patients with hemophilic in Iran between 2007 and 2003.…”

Section: Introductionmentioning

confidence: 99%

The Prevalence of Hepatitis C Virus in Mashhad, Iran: A Population-Based Study

et al. 2013

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BackgroundHepatitis C virus (HCV) infection is a significant health problem throughout the world. Chronic form of the disease is found in about 75% to 85% of the newly infected individuals. The chronic infection may lead to severe forms including chronic liver disease, cirrhosis and with a higher mortality rate, hepatocellular carcinoma. Since no vaccine has yet been developed against HCV, there is an increasing need to take measures to control the spread of the infection. Therefore, epidemiologic study of the virus is important to manage and monitor the spread of the virus in the community.ObjectivesThe aim of this study was to determine the prevalence of hepatitis C seropositivity in the general population of Mashhad, northeast of Iran.Patients and MethodsThree thousand, eight hundred and seventy (3870) individuals living in the city of Mashhad were recruited using cluster sampling method. HCV seropositivity was determined with HCV antibody detection ELISA kit and was confirmed by reverse transcriptase polymerase chain reaction (RT-PCR) method.ResultsIn this study the overall seroprevalence of hepatitis C was founded to be 0.2% by using ELISA method. However, the overall Hepatitis C virus infection prevalence was found to be 0.13% with RT-PCR method.ConclusionsOur study suggested that the prevalence rate of Hepatitis C virus is below 1% in the general population of Mashhad.

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Seroprevalence and genotyping of hepatitis C virus in multiple transfused Jordanian patients with β-thalassemia major

Cited by 12 publications

References 19 publications

Prevalence and Risk Factors of Hepatitis C Infection (HCV) in Birjand, Iran, 2014

Prevalence and Risk Factors of Hepatitis C Infection (HCV) in Birjand, Iran, 2014

The Epidemiology of Hepatitis C Virus in the Fertile Crescent: Systematic Review and Meta-Analysis

The Prevalence of Hepatitis C Virus in Mashhad, Iran: A Population-Based Study

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