Seroprevalence and molecular characterization of<i>Leishmania</i>in dogs from an endemic area of zoonotic visceral leishmaniasis in Brazil

Lopes, José Maria de Andrade; Michalsky, Érika Monteiro; Silva, Fabiana de O. Lara; Lima, Ana C.V.M. Rocha; Avelar, Daniel Moreira de; Costa, Ailton A. Junior da; França-Silva, João Carlos; Regina-Silva, Shara; Fortes-Dias, Consuelo Latorre; Dias, Edelberto Santos

doi:10.1016/j.ijvsm.2017.02.002

Cited by 7 publications

(3 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…There are reports of significant reductions in canine and human VL cases after the removal of seropositive dogs, as well as no effect after massive euthanasia [41][42][43][44][45][46][47][48][49]. An aggravating factor is that clinically asymptomatic dogs, and infected dogs with divergent serological results are maintained in people's homes, where they act as potential sources for Leishmania vector infection and facilitate the disease transmission cycle [50][51][52][53]. Recently, the Brazilian Ministry of Health approved a proposal for the incorporation of collars impregnated with insecticide (4% deltamethrin) for the control of visceral leishmaniasis in priority municipalities [54].…”

Section: Discussionmentioning

confidence: 99%

The Program for the Control of Visceral Leishmaniasis in Brazil: The Effect of the Systematic Euthanasia of Seropositive Dogs as a Single Control Action in Porteirinha, a Brazilian City with an Intense Transmission of Visceral Leishmaniasis

França-Silva,

Giunchetti,

Mariano

et al. 2023

Pathogens

View full text Add to dashboard Cite

Background: Porteirinha is endemic for visceral leishmaniasis (VL), with intense disease transmission of the disease. We evaluated the impact of canine euthanasia as a single control measure on the incidence of VL in humans and canines. Methods: A prospective observational cohort study was carried out over four years (1998–2002) in 8 of the 12 neighborhoods of the city. The dynamics of canine visceral leishmaniasis (CVL) transmission were evaluated for 2 years, before beginning the screening–culling intervention. The comparative morbidity index (CMI) was used to stratify areas with the greatest risk of CVL, and the spatial distribution of human and canine VL cases was compared using univariate and bivariate K-functions. Results: Human cases conglomerated in three neighborhoods. Spatial clusters were detected for CVL in 1998, 2000, and 2001, but not in 1999, when greater spatial dispersion occurred. The screening and culling intervention reduced the number of human VL cases and decreased the incidence of CVL, mainly in neighborhoods with a high CMI. Conclusions: The systematic euthanasia of seropositive dogs was shown to be an effective control action of the Program for Control of Visceral Leishmaniasis (PCLV) in Brazil. The fundamental role of domestic dogs in the epidemiological chain of VL was reaffirmed.

show abstract

Section: Discussionmentioning

confidence: 99%

The Program for the Control of Visceral Leishmaniasis in Brazil: The Effect of the Systematic Euthanasia of Seropositive Dogs as a Single Control Action in Porteirinha, a Brazilian City with an Intense Transmission of Visceral Leishmaniasis

França-Silva,

Giunchetti,

Mariano

et al. 2023

Pathogens

View full text Add to dashboard Cite

show abstract

“…According to the authors, these animals presented twice the risk of seroconversion as compared to dogs with negative PCR. More recently,in an endemic region of the state of Minas Gerais, Brazil, the parasite in 73% of asymptomatic dogs was found mainly on the skin [239].…”

Section: The Dog's Role In the Visceral Leishmaniasis Transmission Cyclementioning

confidence: 99%

Global Distribution of Canine Visceral Leishmaniasis and the Role of the Dog in the Epidemiology of the Disease

Vilas-Boas,

Nakasone,

Gonçalves

et al. 2024

Preprint

View full text Add to dashboard Cite

Visceral leishmaniasis is a disease caused by protozoa of the species Leishmania (Leishmania) infantum (syn=Leishmania chagasi) and Leishmania (Leishmania) donovani, which are transmitted by hematophagous in-sects of the genera Lutzomyia and Phlebotomus. The domestic dog (Canis familiaris) is considered the main ur-ban reservoir of the parasite due to the high parasite load on its skin, serving as a source of infection for sand-fly vectors and, consequently, perpetuating the disease in the urban environment. Some factors are consid-ered important in the perpetuation and spread of canine visceral leishmaniasis (CVL) in urban areas, such as stray dogs with their errant behavior and houses that have backyards with trees, shade, and organic materi-als, creating an attractive environment for sandfly vectors. CVL is found in approximately 50 countries with the number of infected dogs reaching millions and, due to the difficulty of controlling and diagnosing the disease, the number of infected animals could be even greater. In the four continents endemic for CVL there are reports of disease expansion in endemic countries such as Brazil, Italy, Morocco, and Tunisia, as well as in areas where CVL is not endemic, for example, Uruguay. Socio-environmental factors, such as migration, drought, deforestation, and global warming, have been pointed out as one of the reasons for expansion to ar-eas where it had been absent. Thus, the objective of this review is to address (i) the distribution of CVL in endemic areas (ii) the role of the dog in the visceral leishmaniasis epidemiology and the factors that influence dog infection and spread of the disease, and (iii) the challenges faced in the control of CVL.

show abstract

“…According to the authors, these animals presented twice the risk of seroconversion, as compared to dogs with negative PCR results. More recently, in an endemic region of the state of Minas Gerais, Brazil, the parasite in 73% of asymptomatic dogs was found mainly on the skin [ 212 ].…”

Section: The Dog’s Role In the Visceral Leishmaniasis Transmission Cyclementioning

confidence: 99%

Global Distribution of Canine Visceral Leishmaniasis and the Role of the Dog in the Epidemiology of the Disease

Vilas-Boas,

Nakasone,

Gonçalves

et al. 2024

Pathogens

View full text Add to dashboard Cite

Visceral leishmaniasis is a disease caused by protozoa of the species Leishmania (Leishmania) infantum (syn = Leishmania chagasi) and Leishmania (Leishmania) donovani, which are transmitted by hematophagous insects of the genera Lutzomyia and Phlebotomus. The domestic dog (Canis familiaris) is considered the main urban reservoir of the parasite due to the high parasite load on its skin, serving as a source of infection for sandfly vectors and, consequently, perpetuating the disease in the urban environment. Some factors are considered important in the perpetuation and spread of canine visceral leishmaniasis (CVL) in urban areas, such as stray dogs, with their errant behavior, and houses that have backyards with trees, shade, and organic materials, creating an attractive environment for sandfly vectors. CVL is found in approximately 50 countries, with the number of infected dogs reaching millions. However, due to the difficulty of controlling and diagnosing the disease, the number of infected animals could be even greater. In the four continents endemic for CVL, there are reports of disease expansion in endemic countries such as Brazil, Italy, Morocco, and Tunisia, as well as in areas where CVL is not endemic, for example, Uruguay. Socio-environmental factors, such as migration, drought, deforestation, and global warming, have been pointed out as reasons for the expansion into areas where it had been absent. Thus, the objective of this review is to address (i) the distribution of CVL in endemic areas, (ii) the role of the dog in the visceral leishmaniasis epidemiology and the factors that influence dog infection and the spread of the disease, and (iii) the challenges faced in the control of CVL.

show abstract

Seroprevalence and molecular characterization ofLeishmaniain dogs from an endemic area of zoonotic visceral leishmaniasis in Brazil

Cited by 7 publications

References 24 publications

The Program for the Control of Visceral Leishmaniasis in Brazil: The Effect of the Systematic Euthanasia of Seropositive Dogs as a Single Control Action in Porteirinha, a Brazilian City with an Intense Transmission of Visceral Leishmaniasis

The Program for the Control of Visceral Leishmaniasis in Brazil: The Effect of the Systematic Euthanasia of Seropositive Dogs as a Single Control Action in Porteirinha, a Brazilian City with an Intense Transmission of Visceral Leishmaniasis

Global Distribution of Canine Visceral Leishmaniasis and the Role of the Dog in the Epidemiology of the Disease

Global Distribution of Canine Visceral Leishmaniasis and the Role of the Dog in the Epidemiology of the Disease

Contact Info

Product

Resources

About