Seroprevalence and risk factors of Neospora caninum infection in cattle in China from 2011 to 2020: A systematic review and meta-analysis

Wei, Xinyu; An, Qi; Xue, Nian-Yu; Chen, Yu; Chen, Yingyu; Zhang, Yuan; Zhao, Quan; Wang, Chu-Ren

doi:10.1016/j.prevetmed.2022.105620

Cited by 13 publications

(11 citation statements)

References 43 publications

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“…On the other hand, although N. caninum is a major pathogen of abortion and reproduction problems in cattle and dogs (1-3), its infection in various animal species including the current animals has been reported (7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18). However, this study found higher IgM positivity rates in the horses (91.8%) and chickens (49.5%) than in the yaks and cattle.…”

Section: Discussioncontrasting

confidence: 56%

“…Of the investigated animal species in this study, the IgG positivity was from 0 (cattle) to 97.3% (donkey), while that of IgM was from 19.5 (cattle) to 91.8% (horse). These findings showed the higher epidemiology of neosporosis in current animals in the QTPA compared with the 5.14, 8.4, 1.9, 23.1, and 9.5% IgG seroprevalence in yaks, Tibetan sheep, pigs, chickens, and equines in several provinces in China (12)(13)(14)(15)(16)(17)(18). Moreover, the N. caninum positivity rates of the present animals were also higher than the 13.46% in equines in the world (17), 40% in pigs in Italy (26), and 3.9% in camels in Iran (27).…”

Section: Discussionmentioning

confidence: 90%

“…For donkeys, they were likely exposed to foods and water contaminated with oocysts in Haidong city, while the limitation of this study is that the sample size is too small for donkeys. On the other hand, although N. caninum is a major pathogen of abortion and reproduction problems in cattle and dogs ( 1 – 3 ), its infection in various animal species including the current animals has been reported ( 7 – 18 ). However, this study found higher IgM positivity rates in the horses (91.8%) and chickens (49.5%) than in the yaks and cattle.…”

Section: Discussionmentioning

confidence: 99%

“…Neospora caninum infection in a large spectrum of wild and domestic animals was described in many countries, especially cattle and dogs (1,3,5,(7)(8)(9)(10)(11). Although the prevalence of neosporosis in various animal hosts has been determined in several areas in China (12)(13)(14)(15)(16)(17)(18), limited data are available on domestic and wild animals exposed to N. caninum in the Qinghai-Tibetan Plateau Area (QTPA). For the epidemiology of neosporosis, serological ELISA diagnostic methods with highly specific and sensitive characteristics have been developed, and ELISAs based on specific antigens derived from N. caninum, especially for the case of surface antigen 1 (NcSAG1) and dense granule protein 7 (NcGRA7), were used to perform serological testing on parasitic infections in a large number of animal samples (19)(20)(21)(22)(23).…”

Section: Introductionmentioning

confidence: 99%

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Seroepidemiology of Neosporosis in Various Animals in the Qinghai-Tibetan Plateau

Yang

et al. 2022

Front. Vet. Sci.

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Neosporosis is a worldwide infectious disease caused by intracellular parasite Neospora caninum that is a major pathogen of abortion in cattle and neurological disorders in other hosts. However, limited data are available on animals exposed to N. caninum in the Qinghai-Tibetan Plateau Area (QTPA), and little is known about whether animals in the plateau area play an important role in the epidemiology of N. caninum. Therefore, indirect ELISAs based on a combination of NcSAG1 and NcGRA7 antigens were developed to examine both N. caninum-specific IgG and IgM antibodies in Tibetan sheep, yak, cow, pig, cattle, horse, chicken, camel, and donkey from the QTPA in this study. The results showed that all current species present- IgG and IgM-positive animals, and that the overall seroprevalence of N. caninum were 18.6 (703/3,782) and 48.1% (1,820/3,782) for the IgG and IgM antibodies, respectively. Further analysis found significant differences from different altitudes in IgG in Tibetan sheep and IgM in the yak. Hence, the present serological results indicate that the tested animal populations in the QTPA are suffering from N. caninum infections or have become carriers of N. caninum antibodies. To the best of our knowledge, this is the first report on current N. caninum-infected animals in the QTPA, the first epidemiology of neosporosis in cow and camel in China, and the first record of N. caninum IgM antibodies in all the surveyed animals in China. This study provides the latest valuable data on the epidemiology of neosporosis in China and in plateau areas of the world.

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Section: Discussioncontrasting

confidence: 56%

Section: Discussionmentioning

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Seroepidemiology of Neosporosis in Various Animals in the Qinghai-Tibetan Plateau

Yang

et al. 2022

Front. Vet. Sci.

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“…Similarity, a history of abortion was confirmed to be highly related with the seroprevalence of T. gondii in both the serum and milk samples in the present study. It is noteworthy that another very important protozoan, Neospora caninum , cannot be disregarded, it has been considered to play a crucial role in the reproductive failure of cattle and widely distributed in China [ 31 ]. Thus, it is necessary to prepare and implement routine surveillance of T. gondii and N. caninum infection at all levels, including individual, herd, and farm levels.…”

Section: Discussionmentioning

confidence: 99%

Toxoplasma gondii Antibodies in Raw Milk and Sera of Cows in China

et al. 2022

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Toxoplasma gondii is a worldwide food-borne protozoa that has harmful influences on animal and human health. Raw milk containing T. gondii has been considered as one of the possible infectious sources for humans. Although China is one of the world’s leading milk consumers, there is still no study to investigate the seroprevalence of T. gondii in raw cow milk in China; especially for cows in rural areas. Thus, we conducted this study to examine the specific anti-T. gondii IgG-antibody in the raw milk and sera of domestic cows in China. In total, 894 cows were randomly selected from rural areas in northeastern China. The positive rate of T. gondii in the milk and serum samples were 6.38% (57/894) and 7.16% (64/894), respectively. Moreover, a history of abortion (OR = 2.03, 95% CI: 1.11–3.72, p = 0.022) was identified as the only risk factor for T. gondii infection in the studied cows. This study investigated the seroprevalence of T. gondii in the raw milk and sera of cows in China; it provided timely and useful data for public health and food safety, especially in rural areas.

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Seroprevalence and associated risk factors for Neospora caninum infection in dairy cattle in South Africa

Tagwireyi,

Thompson,

Garcia

et al. 2024

Parasitol Res

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Bovine neosporosis is a widespread parasitic disease associated with significant economic losses. Its effects on the reproductive performance of cows have resulted in losses that run into the hundreds of millions of US dollars in dairy industries in various countries (Reichel et al., Int J Parasitol 43:133–142, 2013). Due to outdated and scant information on the occurrence of Neospora caninum infection in South Africa, the study aimed to determine the seroprevalence and risk factors associated with infection in dairy cattle in South Africa. A total of 1401 blood samples were randomly collected from cattle on 48 dairy farms in seven of the nine provinces in South Africa. A close-ended questionnaire was used in a cross-sectional study to obtain farm-level and animal-level data. Serological testing was done using a commercial IDvet Screen® Neospora caninum Indirect ELISA. An overall seroprevalence, adjusted for test sensitivity and specificity, of 2.3% (95% CI, 1.3–4.1) was detected and 48% (23/48) of sampled farms had at least one animal testing positive. The highest seroprevalence of N. caninum was in the KwaZulu-Natal province with 7.5% (95% CI, 3.8–14.3), and the lowest in Western Cape with 0.1% (95% CI, 0–1.2). The highest within-farm seroprevalence of 25% was detected on a farm in the North West Province. In a multivariable logistic regression model, the odds of N. caninum seropositivity were higher in Holstein–Friesian cattle when compared to other breeds. Good hygiene was identified as a protective factor. Cattle left out on pasture had increased odds of testing positive for N. caninum compared to those that were penned. The odds of testing seropositive for N. caninum was higher on farms that practised segregation of cattle into different age groups. The purchase of replacement animals was a significant risk factor, as open herds had increased odds of N. caninum seropositivity. Cattle on farms that did not have a specific calving location were more likely to be seropositive. This is the first such study in South Africa and shows that N. caninum is widely distributed in the country at a low seroprevalence, but it may be a cause of concern on certain farms.

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Seroprevalence and risk factors of Neospora caninum infection in cattle in China from 2011 to 2020: A systematic review and meta-analysis

Cited by 13 publications

References 43 publications

Seroepidemiology of Neosporosis in Various Animals in the Qinghai-Tibetan Plateau

Seroepidemiology of Neosporosis in Various Animals in the Qinghai-Tibetan Plateau

Toxoplasma gondii Antibodies in Raw Milk and Sera of Cows in China

Seroprevalence and associated risk factors for Neospora caninum infection in dairy cattle in South Africa

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