Seroprevalence and Risk Factors of the Helicobacter pylori Infection in Bukavu City in the Democratic Republic of Congo

Ngoma, Patrick de Jésus; Longo-Mbenza, Benjamin; Tshibangu‐Kabamba, Evariste; Matungo, Bellarmin; Lupande, David; Malu, Christian; Kengibe, Pitchou; Yaba, Antoine Tshimpi Wola; Nlombi, Charles Mbendi; Fiasse, René; Dahma, Hafid; Kabinda, Jeff Maotela; Yamaoka, Yoshio; Nkodila, Aliocha; Deyi, Véronique Yvette Miendje

doi:10.4236/oalib.1108032

Cited by 3 publications

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“…This is one of few existing studies on H. pylori in the DRC. Rare available data show that it is a common infection with rates approaching 90% 9,10 . Unfortunately, there is almost no local bacteriological data as well as national policies according to recommendations 5 .…”

Section: Discussionmentioning

confidence: 99%

“…Rare available data show that it is a common infection with rates approaching 90%. 9 , 10 Unfortunately, there is almost no local bacteriological data as well as national policies according to recommendations. 5 In these conditions, care providers are obliged to use empirical prescriptions without scientific evidence.…”

Section: Discussionmentioning

confidence: 99%

“…Nevertheless, there are some scarce studies including a community-based study which had found in 2020 a prevalence of 89% in the city of Bukavu, Eastern of DRC. 9 Three decades earlier, an endoscopic study has reported a prevalence of 90% in a rural area of the same region. 10 To our best knowledge, data on bacteriological sensitivity to currently used antibiotic drugs are very scarce.…”

Section: Introductionmentioning

confidence: 99%

“…Although the DR Congo is one of the countries with high prevalence of H. pylori infection, the overall prevalence is not well known. Nevertheless, there are some scarce studies including a community‐based study which had found in 2020 a prevalence of 89% in the city of Bukavu, Eastern of DRC 9 10 …”

Section: Introductionmentioning

confidence: 99%

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Efficacy and tolerability of Helicobacter pylori eradication regimes in South Kivu, Eastern of the Democratic Republic of Congo: A single center observational study

Shindano,

Masimango,

Kishabongo

2024

Health Science Reports

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Background and AimsTreating Helicobacter pylori infections has become a major challenge due to increased antibiotic resistance. The aim of this study was to investigate the efficacy and tolerability of the main standard regimens recommended for H. pylori eradication in Bukavu, Eastern of the Democratic Republic of Congo.MethodsThe study enrolled patients with evidence of H. pylori infection in histological examination or serology testing combined with a positive fecal antigen test. As first‐line treatment, patients were randomized to either a 10‐days (OAC‐10) or a 14‐days (OAC‐14) regimen, employing a combination of omeprazole 20 mg, amoxicillin 1 g, and clarithromycin 500 mg twice daily. In case of failure, a second line regimen was evaluated and included two others protocols: OAC‐10 regimen + levofloxacin 500 mg (OAC‐10+) and the bismuth‐based therapy (pantoprazole + bismuth salt + metronidazole + tetracycline) during 10 days. Our primary endpoint was H. pylori eradication and secondarily, the compliance and adverse effects were also evaluated.ResultsA total of 179 patients were enrolled. The eradication rate was 79.2% and 80.5% with the OAC‐10 and OAC‐14 regimen, respectively (p = 0.796). Adverse effects were significant higher in the OAC‐14 group than in the OAC‐10 group (36.5% vs. 57.8%; p < 0.001). On the other hand, the compliance rate was slightly higher in the OAC‐10 group (97.9% vs. 91.6%, p = 0.052) while clinical improvement was almost similar in both groups. Regarding the second line regimen, the bismuth‐based therapy (n = 18) seemed to show a better response with 100% of eradication rate and 100% of clinical improvement.ConclusionThe classic 10‐days triple therapy seems to be as effective as the 14‐days regimen while having in addition a good tolerance. Apart from cost issues, the bismuth‐based therapy seems to be a very good alternative in case of first‐line treatment failure.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Efficacy and tolerability of Helicobacter pylori eradication regimes in South Kivu, Eastern of the Democratic Republic of Congo: A single center observational study

Shindano,

Masimango,

Kishabongo

2024

Health Science Reports

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“…Indeed, eradication of Helicobacter pylori infection has become more di cult over the last decade due to the increase in antimicrobial resistance, particularly to clarithromycin and levo oxacin [11][12][13] . In a recent study conducted in Kinshasa, disturbing rates of in vitro resistance were reported in the study population 14 . While in the Western world, studies of bacterial ecology have led to the establishment of well codi ed therapeutic regimens, these are lacking in developing countries, forcing them to align themselves with Western protocols 15 .…”

Section: Introductionmentioning

confidence: 96%

Assessing of the Therapeutic Efficacy of These 2 Treatment Regimens in the Management of Helicobacter pylori Infection in Kinshasa, Democratic Republic of the Congo: A Prospective cohort study

Tshimpi

Ngoma

Nkodila

et al. 2022

Preprint

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BackgroundHelicobacter pylori (Hp) infection is a worldwide public health problem. Unfortunately, its management poses a problem because of resistance to antibiotics. However, there are codified treatment protocols covering sequential and concomitant quadritherapy with regard to first-line probabilistic treatment. The aim of this study was to assess the therapeutic efficacy of these 2 treatment regimens in the management of Hp infection at Kinshasa.MethodsThis was a mixed study, with documentary, descriptive and interventional approaches, carried out between September 1, 2018 and April 30, 2020.ResultsSixty-four patients were collected, including 36 men against 28 women with a sex ratio of 1H:1F; the mean age was 54 ± 16.5 years. There was an over-representation of senior patients (n = 29); an intermediate number of adult patients (n = 22) and a lower number of young patients (n = 13). 34 and 30 were respectively treated according to the concomitant and sequential regimens. Concomitant quadruple therapy offered an eradication rate of 91.2% compared to 56.7% for sequential quadruple therapy; concomitant treatment, advancing age and absence of risky behavior more quickly predicted the occurrence of eradication success.ConclusionThe present study showed superiority of concomitant quadruple therapy over sequential quadruple therapy in first-line treatment. Alcohol with active smoking had a negative influence, while concomitant quadruple therapy, advancement in age had a positive influence on the success of the eradication of Hp infection.

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Current and Future Perspectives in the Diagnosis and Management of Helicobacter pylori Infection

Shatila

Thomas

2022

JCM

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Helicobacter pylori (Hp) is a prevalent organism infecting almost half the global population. It is a significant concern, given its associated risk of gastric cancer, which is the third leading cause of cancer death globally. Infection can be asymptomatic or present with dyspeptic symptoms. It may also present with alarm symptoms in the case of progression to cancer. Diagnosis can be achieved non-invasively (breath tests, stool studies, or serology) or invasively (rapid urease test, biopsy, or culture). Treatment involves acid suppression and regimens containing several antibiotics and is guided by resistance rates. Eradication is essential, as it lowers the risk of complications and progression to cancer. Follow-up after eradication is similarly important, as the risk of cancer progression remains. There have been many recent advances in both diagnosis and treatment of Hp. In particular, biosensors may be effective diagnostic tools, and nanotechnology, vaccines, and potassium-competitive acid blockers may prove effective in enhancing eradication rates.

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Seroprevalence and Risk Factors of the Helicobacter pylori Infection in Bukavu City in the Democratic Republic of Congo

Cited by 3 publications

References 0 publications

Efficacy and tolerability of Helicobacter pylori eradication regimes in South Kivu, Eastern of the Democratic Republic of Congo: A single center observational study

Efficacy and tolerability of Helicobacter pylori eradication regimes in South Kivu, Eastern of the Democratic Republic of Congo: A single center observational study

Assessing of the Therapeutic Efficacy of These 2 Treatment Regimens in the Management of Helicobacter pylori Infection in Kinshasa, Democratic Republic of the Congo: A Prospective cohort study

Current and Future Perspectives in the Diagnosis and Management of Helicobacter pylori Infection

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