Séroprévalence de la co-infection hépatite B, hépatite C et VIH chez des femmes accouchées à la maternité de l’hôpital Adolphe Sicé de Pointe-Noire en 2010

Bossali, F.; Taty-Taty, R.; Houssissa, P.; N’suele, W.; Ontsira, E. N.; Obengui,

doi:10.1007/s12157-012-0424-1

Cited by 7 publications

(9 citation statements)

References 17 publications

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“…In our study the risk factor significantly associated with HIV-positive pregnant women had a recent history of blood transfusion as have mounted other studies [1] [12]- [15]. This again puts in evidence the whole problem of the high risk faced by recipients of blood products in Sub-Saharan Africa.…”

Section: Discussionsupporting

confidence: 82%

“…The difference can be explained by the fact that our survey was conducted in the general population as the two results (national and serosurveillance) are in sentinel sites used by pregnant women. Our HIV prevalence is lower than that observed in studies conducted in Pointe Noire (7.6%) and Ethiopia (6.6%) [1] [12]. HIV prevalence among pregnant women appears to be a good reflection of the prevalence in the general population in the latter two countries, the overall prevalence is also higher than that of the DRC.…”

Section: Discussioncontrasting

confidence: 67%

“…The seroprevalence of hepatitis C was 4.1% in our study, but no statistically significant association was observed with the factors considered while most studies of risk factors for hepatitis C in pregnant women or in another group showed some relation to history or tattoo, or blood transfusion, or abortion [1] [19] [23] [24].…”

Section: Discussioncontrasting

confidence: 61%

“…In our study we found a prevalence lower than of countries located in highly endemic area. It is less than that found in Pointe Noire but is approaching found in studies in Tunisia and in certain African Arab countries that are part of medium-prevalence countries [1] [2] [18] [19]. It still remains far higher than the prevalence found in some Western countries such as France (0.54%) [20] and Spain [21] (0.1%).…”

Section: Discussionmentioning

confidence: 74%

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Hepatitis B, Hepatitis C and HIV in Pregnant Women in the Community in the Democratic Republic of Congo

Kabinda¹,

Akilimali²,

Miyanga³

et al. 2015

WJA

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Objectives: To determine the prevalence of HBV, HCV and HIV in pregnant women and identify risk factors. Materials and Methods: Descriptive and analytical study on pregnant women in the community Maniema (DRC) between 24 June and 24 July 2013. We enrolled a total of 581 pregnant women. Results: Prevalence among pregnant women was 4.1% (2.5% to 6.3%) for HIV, 5.9% (3.9% to 8.4%) for the HBsAg and 4.1% (2.5% to 6.4%) for hepatitis C. The risk factor was for HIV, blood transfusion history in women. For HBsAg the main risk factor was the tattoo history and no statistically significant factor was found for hepatitis C. Conclusion: To reduce the risk of transmission of hepatitis from mother to child, all pregnant women should be screened prenatally. A strengthening of routine screening of blood products must be done and a health education of the population on the mode of contamination should be conducted.

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Section: Discussionsupporting

confidence: 82%

Section: Discussioncontrasting

confidence: 67%

Section: Discussioncontrasting

confidence: 61%

Section: Discussionmentioning

confidence: 74%

See 2 more Smart Citations

Hepatitis B, Hepatitis C and HIV in Pregnant Women in the Community in the Democratic Republic of Congo

Kabinda¹,

Akilimali²,

Miyanga³

et al. 2015

WJA

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“…Global prevalence of Hepatitis B virus (HBV) infection is distributed in three areas in the world of high (≥8%), intermediate (2-7%) and low (<2%) [2]. In the Republic of Congo, the prevalence of HBsAg is high, with rates oscillating between 6.5% to 17% in the general population and depending on the departments [3][4][5][6].…”

Section: Introductionmentioning

confidence: 99%

Prevalence of Serologic Markers and Risk Factors for Hepatitis B Virus among Pregnant Women in Brazzaville, Congo

2016

IJSR

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Molecular characterization of hepatitis B virus among chronic hepatitis B patients from Pointe Noire, Republic of Congo

Angounda

Ngouloubi

Dzia

et al. 2016

Infect Agents Cancer

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BackgroundChronic Hepatitis B infection is a major health problem in Republic of Congo therefore molecular analysis of HBV strains is important to detect the patients at high risk of disease progression.MethodsSerum samples were obtained from 111 chronic HBV patients in Pointe Noire. HBsAg, HBeAg and HBeAb were detected. A fragment of the preS1 region of HBV was amplified and sequenced to determine genotypes, subgenotypes and to identify mutations.ResultsOf the 111 samples analyzed, 35 patients were asymptomatic carriers (ASC), 24 with a chronic active hepatitis (CAH), 33 with liver cirrhosis (LC) and 19 have a hepatocellular carcinoma (HCC). The mean age were 45 ± 13 year, 88 (79.3 %) were male and 23 (20.7 %) female. The prevalence of HBeAg was 15.3 % and 73 % of subjects were anti-HBe positive. The mean serum level of alanine aminotransferase transaminase (ALT) and aspartate transaminase (AST) was 25.1 ± 9 IU/L and 28.6 ± 10 IU/L respectively. Eighty two samples out of 111 (73.9 %) were genotyped by the analyzing of the S region of HBV, 58 (70.7 %) cases belonged to HBV genotype E and 24 (29.3 %) were genotype A with three subgenotypes; A3 (66.7 %), A4 (20.8 %) and A6 (12.5 %). Prevalence of genotype A was relatively high in CAH (33.3 %) and HCC (31.6 %) patients in comparison with other groups. The most prevalent amino acids substitutions were R38K found in 14 (17.1 %) sequences, following by H44L in 11 (13.4 %), K13E in 8 (9.8 %), N29K in 8 (9.8 %), A35E in 8 (9.8 %), V80I in 7 (8.5 %) and in 6 (7.3 %) sequences for S90T. Different substitutions located in the hepatocyte binding site were higher among patients with LC and HCC (p < 0.05).ConclusionsThis study have shown that HBV genotype E and A were the most frequent strains circulating in Republic of Congo patients. HBV pres1 substitutions found in this study were associated with severe clinical forms of liver diseases. This data have shown the importance of implementing an effective program to fight HBV infection.

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Séroprévalence de la co-infection hépatite B, hépatite C et VIH chez des femmes accouchées à la maternité de l’hôpital Adolphe Sicé de Pointe-Noire en 2010

Cited by 7 publications

References 17 publications

Hepatitis B, Hepatitis C and HIV in Pregnant Women in the Community in the Democratic Republic of Congo

Hepatitis B, Hepatitis C and HIV in Pregnant Women in the Community in the Democratic Republic of Congo

Prevalence of Serologic Markers and Risk Factors for Hepatitis B Virus among Pregnant Women in Brazzaville, Congo

Molecular characterization of hepatitis B virus among chronic hepatitis B patients from Pointe Noire, Republic of Congo

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