Séroprévalence de la cysticercose et facteurs de risque associés chez un groupe de patients vus au Centre Hospitalier Régional de Référence d’Antsirabe, Madagascar

Zafindraibe, Norosoa Julie; Ralalarinivo, Jeannine; Rakotoniaina, Andriamiarimbola Irène; Maeder, Muriel; Andrianarivelo, Mala Rakoto; Contamin, B.; Michault, Alain; Rasamindrakotroka, Andry

doi:10.11604/pamj.2017.28.260.10463

Cited by 6 publications

(4 citation statements)

References 27 publications

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“…Consumption of pork is important in the transmission of Taenia solium infections. Its prevalence is higher among consumers of pork compared to those who do not eat [29]. In our study, a patient contracted neurocysticercosis through the practice of geophagy.…”

Section: Discussionmentioning

confidence: 57%

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Epilepsy due to Neurocysticercosis: Analysis of a Hospital Cohort

Bugeme¹,

Sow²,

Mukuku³

et al. 2020

J Neurosci Neurol Disord

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Introduction: Neurocysticercosis (NCC) is a common helminthic infection of the nervous system that occurs when humans become intermediate hosts in the life cycle of the pig tapeworm (Taenia solium) after ingesting its eggs. The objective of this study was to analyze socio-demographic, clinical and paraclinical features of patients with NCC in Lubumbashi, DRC. Methods: This is a cross-sectional study conducted over a period of 2 years within the Neuropsychiatric Center of Lubumbashi. Socio-demographic, clinical, paraclinical and therapeutic features were studied. Results: A total of 18 patients with NCC were listed. Epilepsy was found in 72.2% (13/18) of the cases. The mean age of the patients was 30.2 ± 13.5 years; males accounted for 61.2% of the cases. 84.6% were consumers of pork. Generalized epilepsy was found in 84.6% of the cases and hypereosinophilia in 38% of the cases. On the neuroimaging, the parietal location of lesions represented 92.3%; calcifications were the type of lesion in 53.8% of the cases and 69.2% of the cases presented lesions in the 4th evolutionary stage. Electroencephalogram was normal in 84.4% of the cases. Phenobarbital was the antiepileptic drug used in 69.3%; albendazole and prednisone were used in 53.9% of the cases. Conclusion: This study shows that NCC is one of the causes of epilepsy in Lubumbashi. Generalized tonic-clonic seizures are the most common form of presentation and calcified parenchymal lesions are the most common radiological feature of NCC. So, any patient with acute onset of afebrile seizure should be screened for NCC provided other common causes been ruled out.

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Section: Discussionmentioning

confidence: 57%

“…We noted that 84.6% of the patients had contact with pigs (consumers, breeders and sellers). Za indraide, et al [29] found 96.6% of consumers of pork, 39% of whom were breeders. Some studies have shown the link between cysticercal prevalence and the intensity of pig farming [30].…”

Section: Discussionmentioning

confidence: 96%

Epilepsy due to Neurocysticercosis: Analysis of a Hospital Cohort

Bugeme¹,

Sow²,

Mukuku³

et al. 2020

J Neurosci Neurol Disord

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“…A serological survey of human cysticercosis including 4,375 samples between 1994-1999, using an ELISA test for screening and EITB (Enzyme-linked Immunoelectro Transfer Blot) for confirmation, showed a prevalence varying from 7 to 21% in the different provinces [10]. In 2013, a cysticercosis survey at the Antsirabe Hospital (Vakinankaratra region) using a commercial Western Blot (LD Bio Diagnostic, Lyon, France) revealed 14.7% seropositivity (35 positives out of 237) [11].…”

Section: Competing Interestsmentioning

confidence: 99%

Impact of a 3-year mass drug administration pilot project for taeniasis control in Madagascar

et al. 2020

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Taenia solium is endemic in Madagascar and presents a significant burden on the population and the health system. The parasite cycles through humans who host the adult tapeworm, and pigs that host the larval stages. Accidental infection of humans may occur with the larval stages which encyst in the nervous central system causing neurocysticercosis, a major cause of seizure disorders and a public health problem. One of the interventions to facilitate the control of the disease is mass drug administration (MDA) of the human population with taeniacide. Here we describe a pilot project conducted in Antanifotsy district of Madagascar from 2015 to 2017 where three annual rounds of MDA (praziquantel, 10mg/Kg) were undertaken in 52 villages. Changes in the prevalence of taeniasis were assessed before, during and after the treatments. A total of 221,308 treatments were given to all eligible people above 5 years of age representing a 95% coverage of the targeted population. No major adverse effects were notified related to the implementation of the MDA. The prevalence of taeniasis was measured using Kato-Katz and copro-antigen techniques. Analyses undertaken combining the results of the Kato-Katz with copro-antigen, or using the Kato-Katz results alone, showed that there was a significant reduction in taeniasis 4 months after the last MDA, but 12 months later (16 months after the last MDA) the taeniasis prevalence had returned to its original levels. Results of the pilot project emphasize the need of a multisectorial One-Health approach for the sustained control of T. solium.

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“…Taenia solium is endemic in Madagascar, where it has been reported since 1901 (Migliani et al ., 2000 ; Carod and Dorny, 2020 ). Neurocysticercosis is widespread in Madagascar (Andriantsimahavandy et al ., 2003 ), with infection levels in school-aged children a particular concern (Zafindraibe et al ., 2017 ; Carod et al ., 2021 ). It is the main cause of secondary childhood epilepsy (Carod and Dorny, 2020 ) and a major cause of late-onset epilepsy (Andriantsimahavandy et al ., 1997 ) in Madagascar.…”

Section: Introductionmentioning

confidence: 99%

Confirmation by necropsy of a high prevalence of porcine cysticercosis in a rural district of Madagascar

Mananjara,

Rakotoarinoro,

Rakotoarison

et al. 2023

Parasitology

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Neurocysticercosis is recognized as an important health issue in the Malagasy population. To date, investigations into prevalence of infection with the causative agent, Taenia solium, in the parasite's natural animal intermediate hosts, have relied on serological methods which have been found to be non-specific. We determined the prevalence of porcine cysticercosis among pigs from a contiguous area of the Betafo and Mandoto administrative districts, Vakinankaratra Region, Madagascar. One hundred and four slaughter-weight pigs were examined by detailed necropsy examination including slicing of the heart, tongue, masseter muscles, diaphragm and carcase musculature. Thirty-seven animals (35.6%) were found infected with T. solium, representing one of the highest rates of infection ever reported, worldwide. These findings highlight the importance of T. solium in Madagascar and support the need for increased efforts to prevent the parasite's transmission to reduce its burden on the health of the Malagasy population.

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Séroprévalence de la cysticercose et facteurs de risque associés chez un groupe de patients vus au Centre Hospitalier Régional de Référence d’Antsirabe, Madagascar

Cited by 6 publications

References 27 publications

Epilepsy due to Neurocysticercosis: Analysis of a Hospital Cohort

Epilepsy due to Neurocysticercosis: Analysis of a Hospital Cohort

Impact of a 3-year mass drug administration pilot project for taeniasis control in Madagascar

Confirmation by necropsy of a high prevalence of porcine cysticercosis in a rural district of Madagascar

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