Seroprevalence of Alphaviruses (Togaviridae) among Urban Population in Nouakchott, Mauritania, West Africa

Abdoullah, Bedia; Durand, Guillaume André; Basco, Leonardo K.; El Bara, Ahmed; Bollahi, Mohamed Abdallahi; Bosio, Laurent; Geulen, Manon; Briolant, Sébastien; Boukhary, Ali Ould Mohamed Salem

doi:10.3390/v15071588

Cited by 5 publications

(1 citation statement)

References 57 publications

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“…More recently, a cross-sectional seroprevalence study involving 1300 non-febrile patients consulting at the Nouakchott hospital center during 2021 reported for the first time serological evidence of previous exposure to chikungunya virus (CHIKV) with a seroprevalence of 2.8% and co-circulation of two other alphaviruses, o'nyong-nyong virus (ONNV) and Semliki Forest virus (SVF), in Nouakchott with a seroprevalence of 2.3% in the study population [75].…”

Section: Other Arbovirusesmentioning

confidence: 99%

Arthropod-Borne Viruses in Mauritania: A Literature Review

El Ghassem,

Abdoullah,

Deida

et al. 2023

Pathogens

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During the past four decades, recurrent outbreaks of various arthropod-borne viruses have been reported in Mauritania. This review aims to consolidate the current knowledge on the epidemiology of the major arboviruses circulating in Mauritania. Online databases including PubMed and Web of Science were used to retrieve relevant published studies. The results showed that numerous arboviral outbreaks of variable magnitude occurred in almost all 13 regions of Mauritania, with Rift Valley fever (RVF), Crimean–Congo hemorrhagic fever (CCHF), and dengue (DEN) being the most common infections. Other arboviruses causing yellow fever (YF), chikungunya (CHIK), o’nyong-nyong (ONN), Semliki Forest (SF), West Nile fever (WNF), Bagaza (BAG), Wesselsbron (WSL), and Ngari (NRI) diseases have also been found circulating in humans and/or livestock in Mauritania. The average case fatality rates of CCHF and RVF were 28.7% and 21.1%, respectively. RVF outbreaks have often occurred after unusually heavy rainfalls, while CCHF epidemics have mostly been reported during the dry season. The central and southeastern regions of the country have carried the highest burden of RVF and CCHF. Sheep, cattle, and camels are the main animal reservoirs for the RVF and CCHF viruses. Culex antennatus and Cx. poicilipes mosquitoes and Hyalomma dromedarii, H. rufipes, and Rhipicephalus everesti ticks are the main vectors of these viruses. DEN outbreaks occurred mainly in the urban settings, including in Nouakchott, the capital city, and Aedes aegypti is likely the main mosquito vector. Therefore, there is a need to implement an integrated management strategy for the prevention and control of arboviral diseases based on sensitizing the high-risk occupational groups, such as slaughterhouse workers, shepherds, and butchers for zoonotic diseases, reinforcing vector surveillance and control, introducing rapid point-of-care diagnosis of arboviruses in high-risk areas, and improving the capacities to respond rapidly when the first signs of disease outbreak are identified.

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Section: Other Arbovirusesmentioning

confidence: 99%

Arthropod-Borne Viruses in Mauritania: A Literature Review

El Ghassem,

Abdoullah,

Deida

et al. 2023

Pathogens

Self Cite

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Identifying determinants of waste management access in Nouakchott, Mauritania: a logistic regression model

Ebnou Abdem,

Azmi,

Diop

et al. 2024

Data & Policy

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Access to waste management services is crucial for urban sustainability, impacting public health, environmental well-being, and overall quality of life. This study employs logistic regression analysis on survey data collected from 1,032 household heads residing in Nouakchott, the capital of Mauritania. The survey investigated key household factors that determine access to waste management services. The findings reveal a significant interplay among waste service provision, the presence of cisterns, housing type and size, and access to electricity. Socioeconomic disparity in service access, with poorer housing formats like shacks receiving substandard services. In contrast, areas with robust electrification report better service access, although inconsistencies remain amid power outages. The research highlights the challenges faced by Riyadh municipality, particularly rapid growth and inadequate infrastructure, which hinder waste management efficiency. Overall, the results not only illuminate Nouakchott’s unique challenges in service provision but also propose actionable recommendations for a sustainable urban future. These recommendations aim to inform and guide targeted policies for improving living conditions and environmental sustainability in urban Mauritania.

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Analytical and clinical evaluation of a duplex RT-qPCR assay for the detection and identification of o’nyong-nyong and chikungunya virus

Wesselmann,

Luciani,

Thirion

et al. 2024

Emerging Microbes & Infections

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The mosquito-borne alphavirus o’nyong-nyong virus (ONNV) has proven its potential to cause major human outbreaks. On the African continent, ONNV causes unspecific febrile illness and co-circulates with the close relative chikungunya virus (CHIKV). The true scale of ONNV burden is poorly understood in Africa, because of the scarce availability of molecular in-house and commercial assays, strong cross-reactivity between ONNV and CHIKV in serological assays and a lack of surveillance. We designed a new RT-qPCR assay targeting the E1 gene for the detection of ONNV that can be used in monoplex or in duplex format, combined with a previously published CHIKV monoplex assay targeting the nsp1. The lower limit of detection with 95% positivity rate was determined to be <10 RNA copies/µL in monoplex and duplex format for both ONNV and CHIKV. Both monoplex assays and the duplex assay proved to be linear within the tested range of approximately 10 8 to 10 2 RNA copies/µl, and showed 100% specificity against a wide panel of arbovirus supernatants as well as several other pathogens in clinical samples. Testing of CHIKV positive serum and ONNV-spiked plasma samples confirmed the suitability of the assays in a clinical setting. The new assays provide a robust tool for molecular ONNV as well as ONNV/CHIKV simultaneous detection and may contribute to clarify the true burden of the two viruses, to improve arbovirus surveillance and to strengthen epidemics preparedness in Africa.

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Seroprevalence of Alphaviruses (Togaviridae) among Urban Population in Nouakchott, Mauritania, West Africa

Cited by 5 publications

References 57 publications

Arthropod-Borne Viruses in Mauritania: A Literature Review

Arthropod-Borne Viruses in Mauritania: A Literature Review

Identifying determinants of waste management access in Nouakchott, Mauritania: a logistic regression model

Analytical and clinical evaluation of a duplex RT-qPCR assay for the detection and identification of o’nyong-nyong and chikungunya virus

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