Seroprevalence of anti-SARS-CoV-2 antibodies and risk factors among healthy blood donors in Luanda, Angola

Sebastião, Cruz S.; Galangue, Manuela; Gaston, Celestina; Van‐Dunen, Rui; Quivinja, Joltim; Lunbungululo, Emiliana; Alfredo, Domingos; Sozinho, Alberto; Teixeira, Alice; Manico, Eunice; Machado, Deodete; Mateus, António; David, Zinga; Paixão, Joana; Neto, Zoraima; Vasconcelos, Jocelyne Neto de; Morais, Joana

doi:10.1186/s12879-021-06814-0

Cited by 11 publications

(23 citation statements)

References 25 publications

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“…A previous study reported that the Angolan general population is mostly from the blood group O and Rh+, 19,29,30 which is in agreement with the ndings of our study (Table 2). Despite this, our results disagree with the results of a recent study carried out in 2020 by Sacomboio et al, where they identi ed a higher prevalence of blood group B (36.4%, n = 36/99) in a population from Luanda 22 , instead of the O group.…”

Section: Discussionsupporting

confidence: 93%

Demographic characteristics and risk factors related to high blood pressure among healthy blood donors from Luanda, Angola

Sebastião¹,

Sacomboio²,

Francisco³

et al. 2022

Preprint

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Hypertension is a public health concern, mainly in resource-limited countries. We investigated the characteristics and risk factors related to high blood pressure in healthy blood donors from Angola. This was a multicentre retrospective study that includes 343 donors from December 2019 to September 2020. Men represented 93% of the population. The mean age was 32 ± 9 years. Mean systolic blood pressure (SBP) was 131 ± 12.3mmHg (ranging from 100mmHg to 160mmHg) and diastolic blood pressure (DBP) was 80.1 ± 9.72mmHg (from 56.0mmHg to 100mmHg). DBP was related to age and gender (p < 0.05). About 7.3% of the donors had high-pressure (> 140/90mmHg). Age between 20–40 years (OR: 2.52, p = 0.043), women (OR: 1.87, p = 0.548), non-urbanized areas (OR: 0.39, p = 0.067), high educational level (OR: 0.76, p = 0.637), employed (OR: 0.49, p = 0.491), voluntary donors (OR: 0.87, p = 0.799), blood group B (OR: 2.06, p = 0.346), and Rh- (OR: 0.26, p = 0.104), were potentially related with high-pressure. The high-pressure cases increased from December 2019 (4%) to September 2020 (28%) (p = 0.019). We showed high pressure among the healthy population. Demographic characteristics, ABO/Rh group, and year’s period are features that should be considered in cardiovascular disease control strategies. Biological and non-biological features related to blood pressure changes should be considered for further studies in the Angolan population.

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Section: Discussionsupporting

confidence: 93%

Demographic characteristics and risk factors related to high blood pressure among healthy blood donors from Luanda, Angola

Sebastião¹,

Sacomboio²,

Francisco³

et al. 2022

Preprint

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“…If its presence is detected without IgM, infection occurred more than one month ago; our data is similar to some studies[10] [11]. On the other hand, other authors report lower seroprevalence of 1.5% positive for IgM and 4.7% positive for IgG in Angola[12] [13]. The high prevalence obtained in our study shows a widespread community transmission of SARS-CoV-2 and a low vaccination coverage which was 0% in our donors.These results corroborate those published by Percivalle et al in Italy indicat-…”

supporting

confidence: 89%

Seroprevalence of SARS-CoV-2 among Blood Donors in the Republic of Congo

Mokono¹,

Nanitelamio²,

Mbani³

et al. 2022

OJBD

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Corona Virus Disease 2019 (COVID-19) is a highly transmissible and pathogenic viral infection caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which erupted in Wuhan, China, in 2019 and has spread worldwide [1]. The objective of this study was to assess the seroprevalence of SARS-CoV-2 among blood donors in the Republic of Congo. Method: This is an analytical and cross-sectional study that was carried out during the period from July to December 2021. Biological analyses were performed with the serological tests n2019 rapid IgG/IgM from Beijing Diagreat Biotechnologies and antigen tests from Abbot using the serum for the detection of anti-SARS-Cov-2 antibodies and nasal mucus for the detection of SARS-Cov-2 antigens. Statistical analysis was performed using SPSS version 22. The Results: Out of 2553 donors recruited in our study, we observed a predominance of male sex with 86.1% or a ratio of 6.19, the age group of 18 -30 years was dominant with 45.9%, family donation represented 59.2%, the dominant profession was workers with 46.9% and the dominant blood group was O Rh positive with 54%. The prevalence of anti-SRAS-CoV-2 antibodies and antigens were respectively 31.4% for anti-SRAS CoV-2 IgG antibodies, 36.7% for anti-SRAS CoV-2 IgM antibodies and 2.93% for SARS-CoV-2 antigen.

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“…30,31 However, it is worth noting that advanced age (over 40 years) has previously been described as an independent risk factor for SARS-CoV-2 infection and severity, even in Angola, as shown by our research team. 4,29,32 In addition, this study reports that adults over 40 years of age are more likely to contract viral infectious diseases and also have a high chance of developing high blood pressure with potential risk for an unfavorable cardiovascular or renal clinical outcome. In terms of ABO/Rh blood groups, it is worth mentioning at the rst stage that different from the Rh + factor that represented over 50% of the Angola population, the blood group O despite being the most prevalent, no longer represents more than 50% of the population (Table 2).…”

Section: Discussionmentioning

confidence: 84%

“…This differs from the prevalence described in a study carried out in 1973 by Spielmann and colleagues, where blood group O represented between 54 to 59% of the Angolan population, 33 suggestings a decrease of blood group O in the population over the years. Indeed, a recent study carried out by our research team, showed a signi cant increase in non-O blood groups, with special attention to blood group B, 29 which, in addition to increasing its prevalence, has been associated with the risk of arterial hypertension in the Angolan population. 34,35 There are important limitations to be considered when interpreting the results of this study.…”

Section: Discussionmentioning

confidence: 92%

“…[25][26][27][28] We previously demonstrated a lower SARS-CoV-2 positivity in blood group O individuals as well as a lower risk of infection compared to non-O individuals. 29 The a nity between SARS-CoV-2 with the cells of the respiratory or gut system as a function of the host's ABO/Rh blood group, is not yet clari ed and is the subject of further investigation in the future. Furthermore, has no scienti c evidence showing whether the blood pressure of the population exposed to SARS-CoV-2 changes according to ABO/Rh blood groups.…”

Section: Discussionmentioning

confidence: 99%

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Blood pressure pattern among blood donors exposed to SARS-CoV-2 in Luanda, Angola

Sebastião

Sacomboio

Francisco

et al. 2022

Preprint

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Background SARS-CoV-2 infection is a global public health concern. Several aspects related to the pattern of infection remain unclear. Herein, we investigated the blood pressure pattern among blood donors exposed to SARS-CoV-2 in Luanda, the capital city of Angola, a sub-Saharan African country. Methods We performed a retrospective analysis containing 343 blood donors from December 2019 to September 2020. Parametric tests compared means while Chi-square and logistic regression checked features associated with high blood pressure and were considered significant when p < 0.05. Results The mean age of blood donors was 32.2 ± 8.81 years (ranging from 18 to 61 years) and 93% of the men's gender. Overall, 4.7% of the studied population had been exposed to SARS-CoV-2. High blood pressure prevalence increased from unexposed to exposed SARS-CoV-2 (6.7–18.8%, p = 0.071). SARS-CoV-2 exposure increase systole (131 ± 12.2mmHg to 136 ± 14.2mmHg, p = 0.098), diastole (79.9 ± 9.53mmHg to 84.2 ± 12.7mmHg, p = 0.086), pulse in beats per minute (72.0 ± 11.1 to 73.7 ± 8.50, p = 0.553), and decrease donating time (6.31 ± 3.72 minutes to 5.48 ± 1.61 minutes, p = 0.371). Chances of having high blood pressure were high [OR: 3.20 (95% CI: 0.85–12.1), p = 0.086] in exposed SARS-CoV-2. Blood donors exposed to SARS-CoV-2 with abnormal donation time increased from the donor up to 40 years to over 40 years (from 35.7–50%, p = 0.696). The mean systolic, diastolic, and pulse pressure were higher for non-O blood group donors (p > 0.05). A statistically significant link was observed, between the Rhesus factor and blood pressure status (p = 0.032). Conclusions We showed important variations in blood pressure indices of the Angolan population exposed to SARS-CoV-2. Older age and non-O blood groups appear to be important biological factors for SARS-CoV-2 infection, as well as the risk of developing cardiovascular disease after or during SARS-CoV-2 exposure. Further studies assessing the impact on cardiovascular functions with ongoing or long-term SARS-CoV-2 exposure in individuals from resource-limited countries should be considered.

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Seroprevalence of anti-SARS-CoV-2 antibodies and risk factors among healthy blood donors in Luanda, Angola

Cited by 11 publications

References 25 publications

Demographic characteristics and risk factors related to high blood pressure among healthy blood donors from Luanda, Angola

Demographic characteristics and risk factors related to high blood pressure among healthy blood donors from Luanda, Angola

Seroprevalence of SARS-CoV-2 among Blood Donors in the Republic of Congo

Blood pressure pattern among blood donors exposed to SARS-CoV-2 in Luanda, Angola

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