Seroprevalence of antibodies against measles, rubella, mumps, varicella-zoster, and<i>B. Pertussis</i>in young adults of Madrid, Spain

González-Escalada, Alba; García-García, Laura; Viguera-Ester, Pablo; Marín-García, Patricia; García, Jesus; Miguel, Ángel Gil de; Gil-Prieto, Ruth

doi:10.4161/hv.25127

Cited by 29 publications

(19 citation statements)

References 30 publications

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“…Higher male seropositivity has also been reported in studies from Mexico ( p = .0007) [24] and Korea ( p = .023) [23]; but studies from Spain [26], Greece [21], and The Gambia [22] have reported no significant differences in seropositivity between genders. Regarding higher male likelihood of recent infection, this has been reported to be significant in a study from The Netherlands [31], non-significant in a study from Denmark [34], higher but significance not reported in one from The Gambia [22], or no significant gender differences in two studies from China [35, 36].…”

Section: Discussionmentioning

confidence: 92%

Seroprevalence of Bordetella pertussis antibodies in adults in Hungary: results of an epidemiological cross-sectional study

Torzsa

Devadiga²,

Tafalla

2017

BMC Infect Dis

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BackgroundPertussis (whooping cough) is well known to be underreported, particularly among adults, who can act as an infectious reservoir, potentially putting susceptible newborns at risk of serious illness. The purpose of this study was to estimate the seroprevalence of pertussis in adults in Hungary.MethodsThis epidemiological, cross-sectional study was conducted in adults in five general practitioners’ practices in Hungary. Serum anti-pertussis toxin immunoglobulin G (anti-PT IgG) antibody levels were analyzed using enzyme-linked immunosorbent assay. Sera were classified following manufacturer’s instructions as: strongly indicative of current/recent infection (≥1.5 optical density [OD] units); indicative of current/recent infection (≥1.0 OD units); seropositive (>0.3 OD units); or seronegative (≤0.3 OD units). Logistic regression was performed to describe the associations between seroprevalence and various characteristics.ResultsBetween 24th April 2014 and 24th April 2015, 1999 adults (60.6% female; mean age 47.4 ± 17.7 years) were included in the analysis. A total of 14.8% were seropositive for anti-PT IgG, 1.1% had a level indicative of current/recent infection, and 0.1% had a level strongly indicative of current/recent infection. Logistic regression showed significant relationships between increased rates of seropositivity and: age ≥60 years (odds ratio [OR], 1.97; 95% confidence interval [CI], 1.39–2.80; p = .0002) or 18–29 years (OR, 1.67; 95% CI, 1.13–2.46; p = .0094) vs. 45–59 years; former smoker (OR, 1.46; 95% CI, 1.08–1.97; p = .014) or current smoker (OR, 1.38; 95% CI, 1.01–1.89; p = .045) vs. never smoker; and male (OR, 1.30; 95% CI, 1.01–1.68; p = .041) vs. female. Also, between increased rates of probable current/recent infection and current smoker (OR, 7.50; 95% CI, 2.32–24.31; p = .0008) or former smoker (OR, 4.07; 95% CI, 1.21–13.64; p = .023) vs. never smoker.ConclusionsApproximately 85% of the adults studied were seronegative and therefore susceptible to pertussis infection. Approximately 1% had anti-PT IgG levels indicative of current/recent pertussis infection, which could potentially be transmitted to susceptible young infants. Vaccination of adults is a key way to indirectly protect infants.Trial registrationClinical Trials.gov NCT02014519. Prospectively registered 12 December 2013.

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Section: Discussionmentioning

confidence: 92%

Seroprevalence of Bordetella pertussis antibodies in adults in Hungary: results of an epidemiological cross-sectional study

Torzsa

Devadiga²,

Tafalla

2017

BMC Infect Dis

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“…Several authors demonstrated that vaccinated individuals have lower GMT compared with those acquiring immunity through natural infection [9,10,[15][16][17]19,[24][25][26]30,34,69,96,99]. There was insufficient information provided to determine if certain vaccination programmes resulted in a lower GMT.…”

Section: Major Findings Of the Reviewmentioning

confidence: 98%

A 16-year review of seroprevalence studies on measles and rubella

Dimech¹,

Mulders

2016

Vaccine

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“…Additionally, apparently nonspecific immune responses in the serum and CSF of MS patients involve nonbrain targets and common infectious agents. Antibodies to measles, rubella, and varicella zoster virus have a Ͼ90% seroprevalence in the population (19), but their intrathecal synthesis is a marker for MS (called MRZ reaction) (20). The antiviral response further includes EBV (also called human herpesvirus 4, HHV-4).…”

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confidence: 99%

High-Density Peptide Microarray Analysis of IgG Autoantibody Reactivities in Serum and Cerebrospinal Fluid of Multiple Sclerosis Patients

Hecker

Fitzner

Wendt

et al. 2016

Molecular & Cellular Proteomics

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Intrathecal immunoglobulin G (IgG Multiple sclerosis (MS)1 is a chronic disease of the central nervous system (CNS) that typically affects young adults, especially women. The disease is characterized by discrete areas of inflammation (lesions), demyelination, axonal loss, and astrogliosis in the brain and spinal cord. The clinical correlate of these processes is a wide range of neurological signs and symptoms involving mobility problems, vision problems, cognitive dysfunction, fatigue, and pain (1, 2). This

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Seroprevalence of antibodies against measles, rubella, mumps, varicella-zoster, andB. Pertussisin young adults of Madrid, Spain

Cited by 29 publications

References 30 publications

Seroprevalence of Bordetella pertussis antibodies in adults in Hungary: results of an epidemiological cross-sectional study

Seroprevalence of Bordetella pertussis antibodies in adults in Hungary: results of an epidemiological cross-sectional study

A 16-year review of seroprevalence studies on measles and rubella

High-Density Peptide Microarray Analysis of IgG Autoantibody Reactivities in Serum and Cerebrospinal Fluid of Multiple Sclerosis Patients

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