Seroprevalence of antibodies against rubella virus in pregnant women in Haiti

Désinor, Olbeg; Anselme, Renette; Laender, Fernando; Saint-Louis, Calerbe; Bien-Aimé, Jean Eddy

doi:10.1590/s1020-49892004000300002

Cited by 22 publications

(9 citation statements)

References 4 publications

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“…The rubella virus plays a significant role in the occurrence of abortion Desinor et al, 2004;Palihawadana et al, 2003). The data presented in this study has found that, the seroprevalance of Rubella virus was in agreement with those reported in other African countries in pregnant women.…”

Section: Discussionmentioning

confidence: 99%

Seroprevalence of Rubella virus among pregnant Sudanese women with history of abortion

Elamin¹,

Khidir²

2017

J. Med. Lab. Diagn.

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Mainly, rubella infections during pregnancy are considered as serious infections worldwide. Since Rubella virus not only infects susceptible women early in pregnancy, they can also be transmitted to the fetus, and might induce birth defects. Accordingly, accurate as well as meticulous diagnosis of rubella infection is crucial during pregnancy. A descriptive, retrospective cross sectional hospital based study was conducted during the period from January 2012 till January 2013; in this context, 107 pregnant women attending Khartoum teaching hospital were enrolled. Needless to mention, the entire participants have history of abortion. Moreover, demographic together with clinical data were retrieved from the patient medical file. Enzyme-linked immunosorbent assay (ELISA) was used for detecting Rubella (IgG and IgM) antibodies using commercial diagnostic kits (DRG Instruments GmbH. Germany). Quantitative analyses for Rubella (IgG and IgM) antibodies were performed; furthermore, the assay result was interpreted as IU/mL. The obtained data were statistically analyzed using Statistical Packages for Social Sciences (SSPS) version 17. Out of a total of 107 participants, 93 were examined for the presence of Rubella IgG and IgM antibodies. Mean age was calculated as 30.3 with standard deviation (SD) ±6.2. Interestingly, rubella IgM was found reactive in 5 participants (5.4%), in contrast, 48 participants (51.6%) were found reactive to Rubella IgG antibodies. The present study found that the age groups of 20-29, and 30-39 have a significant correlation with antibody sero-positive. However, since this study was cross sectional, it is difficult to state whether the occurrence of high antibody titre preceded or followed the abortions. Rubella vaccine and routine screening for rubella should be introduced for pregnant women in this setting. Further research in this area is highly recommended.

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Section: Discussionmentioning

confidence: 99%

Seroprevalence of Rubella virus among pregnant Sudanese women with history of abortion

Elamin¹,

Khidir²

2017

J. Med. Lab. Diagn.

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“…So far, the vaccination program was put in place in Cameroon less than five years ago. WHO statistics show that this virus is present in Cameroon with 83, 159, 58, and 126 confirmed cases in 2004, 2005, 2006, and 2007 respectively [13,14]. These cases were first suspected cases of measles which turned out negative and instead tested positive for Rubella.…”

Section: Introductionmentioning

confidence: 99%

Seroprevalence of Rubella IgM and IgG Antibodies and Associated Risk Factors among Pregnant Women Attending Antenatal Clinic at Bafoussam Regional Hospital, West Region of Cameroon

Noubom¹,

Tseyep²,

Sama³

et al. 2018

J Trop Dis

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Background: Rubella is a contagious vaccine-preventable viral infection. Its etiologic agent, Rubella virus has been identified as a human teratogen capable of causing a spectrum of birth defects known as Congenital Rubella Syndrome (CRS) if the infection occurs within the first trimester of pregnancy. Rubella continues to be a serious public health problem in developing countries. This study focused to find out the seroprevalence and risk factors associated with Rubella infection in pregnant women at the Bafoussam Regional Hospital. Materials and Methods: This was a cross-sectional study carried out among pregnant women attending the antenatal clinic. Clinicians carried out screening of 91 pregnant women for Rubella IgG and IgM antibodies from July to September 2016, using sandwich ELISA kit (SinoBiological Inc, India). A questionnaire captured known risk factors for Rubella among all participants. Risk factors for Rubella were analyzed in a binary logistic model in which not being positive for Rubella was considered the reference condition. Odd ratios calculated at 95% CI, were used to measure the strength of association between the risk factors and Rubella antibodies seropositivity. A p ≤ 0.05 was considered statistically significant. Results: Of the 91 pregnant women who accepted to participate in the study, 93.40% (85/91) were seropositive for Rubella IgM and IgG antibodies. Among the Rubella seropositive women, 87.91% (80/91), 5.49% (5/91) and 5.49% (5/91) were seropositive for IgG antibody, IgM antibody, and both IgM and IgG antibodies respectively. Among the risks factors evaluated, none was found to be an independent risk factor of Rubella infection. Conclusions: The findings from this study show that Rubella virus is circulating in the study area and more women have been and are perhaps still being exposed to this potentially hazardous childbearing age infection and there is a need to inform them on how they could protect themselves from contracting this virus.

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“…We identified over 220 studies that provided cross‐sectional data and nearly 180 studies that reported on immunity for women of child‐bearing age, primarily for rubella. Table summarizes the over 400 cross‐sectional and women of child‐bearing age measles and rubella serological studies…”

Section: Resultsmentioning

confidence: 99%

Systematic Review of Measles and Rubella Serology Studies

Thompson

Odahowski²

2015

Risk Analysis

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Serological tests provide information about individual immunity from historical infection or immunization. Cross-sectional serological studies provide data about the age- and sex-specific immunity levels for individuals in the studied population, and these data can provide a point of comparison for the results of transmission models. In the context of developing an integrated model for measles and rubella transmission, we reviewed the existing measles and rubella literature to identify the results of national serological studies that provided cross-sectional estimates of population immunity at the time of data collection. We systematically searched PubMed, the Science Citation Index, and references we identified from relevant articles published in English. We extracted serological data for comparison to transmission model outputs. For rubella, serological studies of women of child-bearing age provide information about the potential risks of infants born with congenital rubella syndrome. Serological studies also document the loss of maternal antibodies, which occurs at different rates for the different viruses and according to the nature of the induced immunity (i.e., infection or vaccine). The serological evidence remains limited for some areas, with studies from developed countries representing a disproportionate part of the evidence. The collection and review of serological evidence can help program managers identify immunity gaps in the population, which may help them better understand the characteristics of individuals within their populations who may participate in transmission and manage risks.

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Seroprevalence of antibodies against rubella virus in pregnant women in Haiti

Cited by 22 publications

References 4 publications

Seroprevalence of Rubella virus among pregnant Sudanese women with history of abortion

Seroprevalence of Rubella virus among pregnant Sudanese women with history of abortion

Seroprevalence of Rubella IgM and IgG Antibodies and Associated Risk Factors among Pregnant Women Attending Antenatal Clinic at Bafoussam Regional Hospital, West Region of Cameroon

Systematic Review of Measles and Rubella Serology Studies

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