Seroprevalence of Antibody to Varicella Among Somali Refugees

Nysse, Lana J.; Pinsky, Norman A.; Bratberg, Jeffrey; Babar-Weber, Azra Y.; Samuel, Terri T.; Krych, Esther H.; Ziegler, Aaron W.; Jimale, Mahamoud A.; Vierkant, Robert A.; Jacobson, Robert M.

doi:10.1016/s0025-6196(11)60995-6

Cited by 15 publications

(12 citation statements)

References 33 publications

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“…Our study cohort consisted of 89 Somali subjects (≤30 years of age) vaccinated with a single dose of measles–mumps–rubella (MMR) vaccine that were sampled from a previously recruited and described larger cohort of the Somali refugee community residing in Olmsted County, Minnesota (17, 18). We collected demographic information on vaccination status and disease history for measles, mumps and rubella with the help of a bilingual/bicultural physician assisted by a team of phlebotomists and investigators.…”

Section: Methodsmentioning

confidence: 99%

“…Measles, mumps and rubella‐specific circulating immunoglobulin (Ig)G antibody levels were tested in duplicate for each subject’s serum sample using a whole virus‐specific IgG enzyme‐linked immunosorbent assay (MEASELISA II, MUMPS ELISA II and RUBELISA II; BioWhittaker, Walkersville, MD) as a part of a previously described study (17, 18). Measles and rubella serum IgG levels with enzyme immunoassay (EIA) index values ≤0.87 were considered seronegative, index values between 0.88 and 0.99 were considered seroequivocal and index values ≥1.0 were considered seropositive (19).…”

Section: Methodsmentioning

confidence: 99%

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Associations between cytokine/cytokine receptor single nucleotide polymorphisms and humoral immunity to measles, mumps and rubella in a Somali population

et al. 2008

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We genotyped a Somali population (n=85; age ≤ 30 years) for 617 cytokine and cytokine receptor SNPs using Illumina GoldenGate genotyping to determine associations with measles, mumps and rubella immunity. Overall, sixty-one significant associations (p≤0.01) were found between SNPs belonging to cytokine receptor genes regulating Th1 (IL12RB2, IL2RA and B) and Th2 (IL4R, IL10RB) immunity, and cytokine (IL1B, TNFA, IL6 and IFNB1) and cytokine receptor (IL1RA, IFNAR2, IL18R1, TNFRSF1A and B) genes regulating innate immunity, and variations in antibody levels to measles, mumps or rubella. SNPs within two major inflammatory cytokine genes, TNFA and IL6, demonstrated associations with measles-specific antibodies. Specifically, the minor allele variant of rs1799964 (TNFA -1211 C>T) was associated with primarily seronegative values (median EIA index values ≤0.87; p=0.002; q=0.23) in response to measles disease and/or vaccination. A heterozygous variant CT for rs2069849 (IL6 +4272C>T; Phe201Phe) was also associated with seronegative values and a lower median level of antibody response to measles disease and/or vaccination (p=0.004; q=0.36) or measles vaccination alone (p=0.008). Several SNPs within the coding and regulatory regions of cytokine and cytokine receptor genes demonstrated associations with mumps and rubella antibody levels, but were less informative as strong LD patterns and lower frequencies for minor alleles were observed among these SNPs. Our study identifies specific SNPs in innate immune response genes that may play a role in modulating antibody responses to measles vaccination and/or infection in Somali subjects.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Associations between cytokine/cytokine receptor single nucleotide polymorphisms and humoral immunity to measles, mumps and rubella in a Somali population

et al. 2008

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“…Varicella occurs at older ages in tropical countries, and most of these countries do not have varicella vaccination programs, which means that a large proportion of adolescent and adult immigrants from tropical countries (about 30%) are susceptible to the disease. 39,[125][126][127][128] This is important because adults are more likely than children to contract severe varicella, with higher rates of pneumonia, encephalitis, admission to hospital and death. 129 Varicella may also result in poor outcomes for pregnant women and their fetuses and infants.…”

Section: Take-home Messagesmentioning

confidence: 99%

Evidence-based clinical guidelines for immigrants and refugees

Pottie¹,

Greenaway²,

Feightner³

et al. 2010

Canadian Medical Association Journal

397

333

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“…An outbreak of measles was reported in 2017 from Minnesota, U.S., which predominantly affected children of Somali descent [84]. Another study among Somali refugees in Minnesota reported that 18% of the study participants were seronegative for varicella, underscoring the need for enhanced education to improve varicella vaccination rates in these at-risk communities [85]. Another study from Minnesota indicated that childhood vaccination coverage at 36 months was 44% in children born to mothers from Somalia compared with 77% in children born to mothers from Central and South America [86].…”

Section: Vaccine-preventable Diseasesmentioning

confidence: 99%

Infectious Diseases among Refugee Children

Shetty

2019

Children

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In recent years, there has been a substantial increase in refugee and asylum-seeking adults, adolescents and children to high-income countries. Infectious diseases remain the most frequently identified medical diagnosis among U.S.-bound refugee children. Medical screening and immunization are key strategies to reduce the risk of infectious diseases in refugee, internationally adopted, and immigrant children. Notable infectious diseases affecting refugee and other newly arriving migrants include latent or active tuberculosis, human immunodeficiency virus type 1 (HIV), hepatitis B, hepatitis C, vaccine-preventable diseases, malaria, and other parasitic infections. The U.S. Centers for Disease Control and Prevention and the American Academy of Pediatrics have published guidelines for health assessment of newly arriving immigrant, refugee, and internationally adopted children. Although, data on the health risks and needs of refugee exists in some high-income countries, there is an urgent need to develop robust evidence-informed guidance on screening for infectious diseases and vaccination strategies on a broader scale to inform national policies. Innovative approaches to reach migrant communities in the host nations, address health and other complex barriers to improve access to high-quality integrated health services, and strong advocacy to mobilize resources to improve health, safety, and wellbeing for refugee children and their families are urgent priorities.

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Seroprevalence of Antibody to Varicella Among Somali Refugees

Cited by 15 publications

References 33 publications

Associations between cytokine/cytokine receptor single nucleotide polymorphisms and humoral immunity to measles, mumps and rubella in a Somali population

Associations between cytokine/cytokine receptor single nucleotide polymorphisms and humoral immunity to measles, mumps and rubella in a Somali population

Evidence-based clinical guidelines for immigrants and refugees

Infectious Diseases among Refugee Children

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