Seroprevalence of BKV-Antibodies among Cancer Patients and Healthy Individuals

Abstract

BKPyV, a small DNA virus classified into the polyomaviridaefamily, is holoendemic with global distribution among human population.The objective of this study is to determine the prevalence of anti-BK polyomavirus IgG antibodies among cancer patients and healthy controls. In the present study, A total of 85 serum samples were collected (65 cancer patients and 20 healthy controls) with age range between 15-75 years, the femaleto-male ratio was 3:1. All obtained sera samples were tested using ELISA method for the detection of anti-BK polyomavirus IgG antibodies. BKV-IgG seroprevalence show high rate of exposure to the virus 48.23% (41 of 85 samples) revealed positive result (50.77% in cancer patient and 40% in healthy control). Seroprevalence was not different between female and male. The frequency of IgG antibodies decreased from 66.67% in the age group <40 years to 46.94% among age group 40-60 years, and drop again to 38.1% in >60 years old.