Seroprevalence of BV (Macacine Herpesvirus 1) in Bred Cynomolgus Monkeys in Cambodia

Lin, Qing; Yuan, Gailing; Ai, Lin; Li, Juan; Li, Hailong

doi:10.1292/jvms.11-0335

Cited by 4 publications

(1 citation statement)

References 7 publications

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“…This indicates an increase in viral burden with increasing age, similar to HSV in humans. Genital ulcers or lesions in sub-adults and adults could be attributed to sexual maturity and the onset of sexual activities in animals [26] . Also, female baboons begin sexual activities earlier than their male counterparts [8] , which is probably the reason for the relatively higher prevalence of the virus in female adult baboons.…”

Section: Discussionmentioning

confidence: 99%

Molecular Detection and Characterization of Herpesvirus Papio 2 (HVP2) in Wild-Caught Olive Baboons from Selected Regions in Kenya

Kemunto

Kevin²,

Joseph³

et al. 2022

IEM

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Backgrounds: There is a remarkable similarity between Herpesvirus papio 2 (HVP2) infecting baboons and human simplex virus (HSV) in terms of molecular biology, protein functions, and resulting infections. However, no definitive therapy exists, and the available drugs only improve the clinical signs of recurrent or asymptomatic infections. This research results may be useful for studies on the quest for HVP2 curative and preventive drugs in baboon models. Later, a similar study could be done on HSV in humans. Materials & Methods: A total of 60 baboons were sampled from six different counties in Kenya. Of these, 51 cases were wild caught from five counties, and nine cases were from the Institute of Primate Research (IPR) colonies designated as captive baboons. Oral and genital swabs were collected for analysis. The trigeminal ganglia of three study subjects were also aseptically sampled. Polymerase chain reaction test was used to determine the prevalence of HVP2. HVP2-positive samples were sequenced and aligned to GenBank sequences using BLAST to identify specific circulating strains and generate phylogenetic relationships. DnaSP6 was used for genetic diversity analysis. Findings: Among 60 baboons studied, 65% were positive for the virus. One strain, A951, was identified as the prevalent strain. Extremely low fixation index values (Fst) were recorded, showing low genetic diversity within and between subpopulations. Conclusion:The identified strain was non-pathogenic but could be clinically manifested as painful sores on the host's mucosal membranes and cause stillbirths. The virus prevalence was 75.86% in genital samples and 54.86% in oral samples, indicating that oral transmission is less common than genital transmission.

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Section: Discussionmentioning

confidence: 99%

Molecular Detection and Characterization of Herpesvirus Papio 2 (HVP2) in Wild-Caught Olive Baboons from Selected Regions in Kenya

Kemunto

Kevin²,

Joseph³

et al. 2022

IEM

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Low Incidence, High Lethality or Higher Incidence, Lower Lethality: What We Know and Don’t Know About Zoonotic Macacine alphaherpesvirus 1 (Monkey B Virus)

Eberle

Jones‐Engel

2020

Neglected Diseases in Monkeys

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Questioning the Extreme Neurovirulence of Monkey B Virus(Macacine alphaherpesvirus 1)

Eberle

Jones‐Engel

2018

Advances in Virology

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Monkey B virus (Macacine alphaherpesvirus 1; BV) occurs naturally in macaques of the genus Macaca, which includes rhesus and long-tailed (cynomolgus) monkeys that are widely used in biomedical research. BV is closely related to the human herpes simplex viruses (HSV), and BV infections in its natural macaque host are quite similar to HSV infections in humans. Zoonotic BV is extremely rare, having been diagnosed in only a handful of North American facilities with the last documented case occurring in 1998. However, BV is notorious for its neurovirulence since zoonotic infections are serious, usually involving the central nervous system, and are frequently fatal. Little is known about factors underlying the extreme neurovirulence of BV in humans. Here we review what is actually known about the molecular biology of BV and viral factors affecting its neurovirulence. Based on what is known about related herpesviruses, areas for future research that may elucidate mechanisms underlying the neurovirulence of this intriguing virus are also reviewed.

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Seroprevalence of BV (Macacine Herpesvirus 1) in Bred Cynomolgus Monkeys in Cambodia

Cited by 4 publications

References 7 publications

Molecular Detection and Characterization of Herpesvirus Papio 2 (HVP2) in Wild-Caught Olive Baboons from Selected Regions in Kenya

Molecular Detection and Characterization of Herpesvirus Papio 2 (HVP2) in Wild-Caught Olive Baboons from Selected Regions in Kenya

Low Incidence, High Lethality or Higher Incidence, Lower Lethality: What We Know and Don’t Know About Zoonotic Macacine alphaherpesvirus 1 (Monkey B Virus)

Questioning the Extreme Neurovirulence of Monkey B Virus(Macacine alphaherpesvirus 1)

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