Seroprevalence of Chagas disease in Southern Brazilian cardiac patients and their knowledge about the parasitosis and vectors

Dutra, A. S.; Stauffert, Dulce; Bianchi, Tanise Freitas; Ribeiro, Daniel Rios Pinto; Villela, Marcos Marreiro

doi:10.1590/1519-6984.227465

Cited by 3 publications

(3 citation statements)

References 14 publications

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“…Dutra et al . 26 carried out a study in patients with heart diseases who used the public assistance service provided by the Cardiology Outpatient Clinic that belongs to the UFPel, in Pelotas, RS State. These patients, who came from Cangucu, Herval, Pinheiro Machado and Piratini, counties in which CD was considered endemic in the 1980’s.…”

Section: Discussionmentioning

confidence: 99%

Current situation of Chagas disease vectors (Hemiptera, Reduviidae) in Southern Rio Grande do Sul State, Brazil

Bianchi

Jeske

Grala

et al. 2021

Rev. Inst. Med. trop. S. Paulo

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Chagas disease (CD) has been considered endemic in the South of Rio Grande do Sul (RS) State, Brazil. This study aimed at evaluating the occurrence of Trypanosoma cruzi vectors based on the main species captured in Southern Rio Grande do Sul State from 2008 to 2019. The study area comprised counties that belong to the 3 rd Regional Health Coordination (RHC) and to the 7 th RHC, whose headquarters are in Pelotas and Bage, respectively. The study was based on secondary data provided by the partnership between the Federal University of Pelotas, Rio Grande do Sul State (UFPel-RS) and the State Health Surveillance Center in RS (SCHS-RS). One thousand and four hundred triatomines were captured in the area supervised by the 3 rd RHC, mainly in Cangucu (37.7%), Piratini (22.4%) and Pinheiro Machado (15.1%), while, in the area supervised by the 7 th RHC, the largest number of triatomines was captured in Lavras do Sul (64.15%). In both areas, Triatoma rubrovaria (90.6%) and Panstrongylus tupynambai (7.4%) were the most common species. Most were captured inside households but T. cruzi -positive insects were not found in the period under study. The results of this study show that, in Southern Rio Grande do Sul State, there is still a high rate of triatomine household invasion and dispersal, mainly by T. rubrovaria . Thus, the entomological surveillance should be maintained with the participation of the population and further studies should be deepened in the area.

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Section: Discussionmentioning

confidence: 99%

Current situation of Chagas disease vectors (Hemiptera, Reduviidae) in Southern Rio Grande do Sul State, Brazil

Bianchi

Jeske

Grala

et al. 2021

Rev. Inst. Med. trop. S. Paulo

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“…It should be mentioned that a factor that may interfere with the number of captures of T. rubrovaria in RS is the population’s knowledge of vectors. A study showed that 45.3% of patients with cardiovascular diseases treated in Pelotas city, RS, were not capable of identifying triatomines 24 .…”

Section: Discussionmentioning

confidence: 99%

Triatoma rubrovaria (Hemiptera, Reduviidae, Triatominae) in the Pampa biome, Brazil: a retrospective study of its occurrence and abundance

Souza,

Santos,

Bedin

et al. 2023

Rev. Inst. Med. trop. S. Paulo

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Triatoma rubrovaria has been captured in some areas of Rio Grande do Sul State (RS), Brazil, as this species can be found in the Pampa biome. Its distribution across this biome should be described in detail to verify the potential of this vector to transmit Trypanosoma cruzi . This study aimed to investigate the occurrence of T. rubrovaria in the Pampa biome and transitional areas of RS. The collected information resulted from the analysis of secondary data provided by the Centro Estadual de Vigilancia em Saude (CEVS – State’s Center of Health Surveillance). The following aspects were taken into consideration: the year in which the insect was captured, the city, the number of specimens captured, invasion or domiciliation, the notification in the household, surroundings or both, and T. cruzi infection. The data comprised the period from 2009 to 2020, in 109 cities located in the Pampa biome and 98 located in transitional areas. The Pampa biome exhibited 85% of the occurrences of T. rubrovaria, while 1.2% of specimens were T. cruzi- like positive. Both the first and second biennia concentrated 64.6% of captures. Alegrete city, Cangucu city and Piratini city were the locations in the Pampa where the largest numbers of specimens were found. Regarding the transitional areas, Roque Gonzales city, Santiago city and Santana da Boa Vista city exhibited the largest numbers. Most insects were adults, which were found in households. Even though positivity for T. cruzi -like was low, the species still has epidemiological importance in the region.

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“…Trypanosoma cruzi is the causative agent of Chagas disease or American trypanosomiasis, which infects about six to seven million people worldwide, mostly in Latin America (WHO, 2020;Bianchi et al, 2021), considered a typical disease of low-income population developing countries (Dutra et al, 2021). In fact, vectorborne transmission is limited to areas of South, Central and North Americas (Bern, 2015).…”

Section: Introductionmentioning

confidence: 99%

Bioinformatics and expression analysis of the Xeroderma Pigmentosum complementation group C (XPC) of Trypanosoma evansi in Trypanosoma cruzi cells

et al. 2023

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Nucleotide excision repair (NER) acts repairing damages in DNA, such as lesions caused by cisplatin. Xeroderma Pigmentosum complementation group C (XPC) protein is involved in recognition of global genome DNA damages during NER (GG-NER) and it has been studied in different organisms due to its importance in other cellular processes. In this work, we studied NER proteins in Trypanosoma cruzi and Trypanosoma evansi, parasites of humans and animals respectively. We performed three-dimensional models of XPC proteins from T. cruzi and T. evansi and observed few structural differences between these proteins. In our tests, insertion of XPC gene from T. evansi (TevXPC) in T. cruzi resulted in slower cell growth under normal conditions. After cisplatin treatment, T. cruzi overexpressing its own XPC gene (TcXPC) was able to recover cell division rates faster than T. cruzi expressing TevXPC gene. Based on these tests, it is suggested that TevXPC (being an exogenous protein in T. cruzi) interferes negatively in cellular processes where TcXPC (the endogenous protein) is involved. This probably occurred due interaction of TevXPC with some endogenous molecules or proteins from T.cruzi but incapacity of interaction with others. This reinforces the importance of correctly XPC functioning within the cell.

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Seroprevalence of Chagas disease in Southern Brazilian cardiac patients and their knowledge about the parasitosis and vectors

Cited by 3 publications

References 14 publications

Current situation of Chagas disease vectors (Hemiptera, Reduviidae) in Southern Rio Grande do Sul State, Brazil

Current situation of Chagas disease vectors (Hemiptera, Reduviidae) in Southern Rio Grande do Sul State, Brazil

Triatoma rubrovaria (Hemiptera, Reduviidae, Triatominae) in the Pampa biome, Brazil: a retrospective study of its occurrence and abundance

Bioinformatics and expression analysis of the Xeroderma Pigmentosum complementation group C (XPC) of Trypanosoma evansi in Trypanosoma cruzi cells

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