Seroprevalence of Cytomegalovirus Antibodies and Primary Infection among Women and Infants in Iran: A Meta-Analysis

Farshidi, Fereshteh; Abedi, Ghasem; Moosazadeh, Mahmood; Afshari, Mahdi

doi:10.17795/ijcp-3704

Cited by 3 publications

(2 citation statements)

References 30 publications

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“…[2,6,7] The anti-CMV IgG prevalence in the general population (Group B) was 75.2% which was also comparable to the previous studies. [8][9][10] Looking at the age distribution of the anti-CMV IgG-positive cases in Group A, 46 (92%) cases were in the age group of >40-60 years, 43 (86%) cases were in the age group of 18-40 years, and 21 (84%) cases were in the age group of >60-85 years. The previous authors have also reported similar findings.…”

Section: Discussionmentioning

confidence: 99%

Coinfection of Cytomegalovirus (Immunoglobulin G) Antibody in Anti-hepatitis C Virus Seropositive Cases at a Tertiary Care Hospital

Poorna¹,

Mohan²,

Tarana³

et al. 2021

JMSH

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Context: Cytomegalovirus (CMV) infection enhances hepatitis C virus (HCV) pathogenesis as it prevents the normal mechanisms which are responsible for HCV clearance, thus plays a key role in HCV persistence and pathogenicity. Aims: An individual develops lifetime CMV (immunoglobulin G [IgG]) seropositivity, after primary infection after which CMV establishes latency with intermittent reactivation. Thus, the present study was undertaken to look for coinfection of CMV (IgG) in HCV seropositive cases in the hospital.

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Section: Discussionmentioning

confidence: 99%

Coinfection of Cytomegalovirus (Immunoglobulin G) Antibody in Anti-hepatitis C Virus Seropositive Cases at a Tertiary Care Hospital

Poorna¹,

Mohan²,

Tarana³

et al. 2021

JMSH

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“…In general female population CMV IgG seroprevalence is 51.7-95.7%, while the IgM seroprevalence is 4.1 to 6.3%, while in women with bad obstetric history (BOH) the CMV IgG seroprevalence is with a range of 91.2% -96.6% and 3.8% to 9.46% for IgM seroprevalence [15][16][17][18][19]. The association between CMV infection and age is with conflicting results, however, some study suggest that CMV infection is increased in women with age [16].…”

Section: High-risk Womenmentioning

confidence: 99%

Maternal Infections Associated with Bad Obstetric Outcome: Cytomegalovirus and Herpes Simplex Virus.

Alsamarai¹,

Hassan

2019

Int J Med Sci

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Cytomegalovirus (CMV) infection is with global distribution and range of 30-100%. CMV infection is the most common congenital viral infection worldwide . The sign of congenital CMV infection encountered most frequently is hearing loss, which wills 12.6% of congenitally infected newborns and congenital CMV infection form 10-20% as a cause of total hearing loss in children. About10% of the live-born infants with congenital CMV infection are symptomatic at birth. Where as an additional 10% of the infected newborns will develop permanent sequelae in the following years. Herpes simplex virus (HSV) is an abundant, enveloped, and double stranded DNA virus, belonging to the family of Herpesviridae transmitted across mucosal membranes and non intact skin, with ability to induce chronic latent infection. Susceptibility to HSV infection is associated with HLA antigens. The virus type incidence is about the same for both HSV-1 and HSV-2 strains, while HSV-2 is the most predominant in recurrent infections. HVS -1 is the common strain in labial herpetic infection, while HSV-2 is the predominant in genital infection. The site of latency is the trigeminal ganglia for labial herpetic infection and lumbosacral ganglia for genital herpetic infection. Changes in sexual behaviors of young adults may partly explain its higher incidence.

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miR-155 and miR-92 levels in ALL, post-transplant aGVHD, and CMV: possible new treatment options

Saadi

Nikandish

Ghahramani

et al. 2023

J Egypt Natl Canc Inst

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Background Acute lymphoblastic leukemia (ALL) is a malignancy that leads to altered blast cell proliferation, survival, and maturation and eventually to the lethal accumulation of leukemic cells. Recently, dysregulated expression of various micro-RNAs (miRNAs) has been reported in hematologic malignancies, especially ALL. Cytomegalovirus infection can induce ALL in otherwise healthy individuals, so a more detailed evaluation of its role in ALL-endemic areas like Iran is required. Methods In this cross-sectional study, 70 newly diagnosed adults with ALL were recruited. The expression level of microRNA-155(miR-155) and microRNA-92(miR-92) was evaluated by real-time SYBR Green PCR. The correlations between the miRNAs mentioned above and the severity of disease, CMV infection, and acute graft vs. host disease after hematopoietic stem cell transplantation (HSCT) were assessed. B cell and T cell ALL distinction in the level of miRNAs was provided. Results After the statistical analysis, our results indicated a marked increase in the expression of miR-155 and miR-92 in ALL patients vs. healthy controls (*P = 0.002–*P = 0.03, respectively). Also, it was shown that the expression of miR-155 and miR-92 was higher in T cell ALL compared to B cell ALL (P = 0.01–P = 0.004, respectively), CMV seropositivity, and aGVHD. Conclusion Our study suggests that the plasma signature of microRNA expression may act as a powerful marker for diagnosis and prognosis, providing knowledge outside cytogenetics. Elevation of miR-155 in plasma can be a beneficial therapeutic target for ALL patients, with consideration of higher plasma levels of miR-92 and miR-155 in CMV + and post-HSCT aGVHD patients.

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Seroprevalence of Cytomegalovirus Antibodies and Primary Infection among Women and Infants in Iran: A Meta-Analysis

Cited by 3 publications

References 30 publications

Coinfection of Cytomegalovirus (Immunoglobulin G) Antibody in Anti-hepatitis C Virus Seropositive Cases at a Tertiary Care Hospital

Coinfection of Cytomegalovirus (Immunoglobulin G) Antibody in Anti-hepatitis C Virus Seropositive Cases at a Tertiary Care Hospital

Maternal Infections Associated with Bad Obstetric Outcome: Cytomegalovirus and Herpes Simplex Virus.

miR-155 and miR-92 levels in ALL, post-transplant aGVHD, and CMV: possible new treatment options

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