Seroprevalence of cytomegalovirus antibodies in blood donors in southern, Brazil

Souza, Marli Adelina de; Passos, Ana Maria; Treitinger, Arício; Spada, Celso

doi:10.1590/s0037-86822010000400004

Cited by 53 publications

(42 citation statements)

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“…This differs from previous studies, in which this antibody was more prevalent in older age ranges Brazil studies which showed a significantly increased seropositivity with increasing age of blood donors [14]. This may possibly due to earlier acquisition of CMV infection in Yemen in childhood compared to the western populations, leading to higher seroprevalence even in younger adults [10,19].…”

Section: Resultscontrasting

confidence: 86%

“…The seropositive for CMV IgG antibodies among Yemeni blood donors was 96.6% indicating past exposure to infection the high seroprevalence in Yemen and developing countries as India, Brazil and Nigeria is in contrast to Western literature which describes seroprevalence IgG in voluntary blood donors ranging from 38% to 75% in different parts of the developed world [13][14][15]. The high seroprevalence among Yemeni populations indicates the endemicity of infection.…”

Section: Resultsmentioning

confidence: 83%

“…This rate 96.6% is higher than that reported by other studies performed in Japan and India showed 84% and 61% of adults had the antibodies respectively [10,11]. On the other hand, WHO sponsored survey of complement-fixing antibodies against CMV and reported frequencies ranging from 40% in highly industrialized areas to 100% in developing countries of CMV-IgG antibodies [2,12].The seropositive for CMV IgG antibodies among Yemeni blood donors was 96.6% indicating past exposure to infection the high seroprevalence in Yemen and developing countries as India, Brazil and Nigeria is in contrast to Western literature which describes seroprevalence IgG in voluntary blood donors ranging from 38% to 75% in different parts of the developed world [13][14][15]. The high seroprevalence among Yemeni populations indicates the endemicity of infection.…”

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confidence: 99%

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Seroprevalence of Cytomegalovirus among Healthy Blood Donors in Sana'a City, Yemen

Al-Arnoot¹

2017

INID

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IntroductionCytomegalovirus (CMV) is a member of the human herpes family of viruses. It has emerged as a significant cause of morbidity and mortality in children and immunocompromised adults. It transmitted by direct or indirect, close or intimate person-to-person contact. Sources of the virus include oropharyngeal secretions, urine, cervical, vaginal excretions, semen, breast milk, tears, faeces and blood [1]. *Corresponding author:Saad Al-Arnoot, Microbiology Division, Department of Biology, Faculty of Science, Sana'a University, Sana'a, Yemen, Tel: +967 00967774667900; E-mail: saad.alarnoot@gmail.com According to the result of a WHO cooperative study involving equal numbers of male and female healthy blood donors between 20-40 years of age are shown. The seroprevalence of antibody in that study ranges from 40-100% [2]. However, in Yemen, a few studies have investigated the prevalence of CMV antibody which seroprevalence of CMV antibody ranges between 68%-100% among pregnant women [3][4][5].The American Association of Blood Banks has recommended transfusion from donors who are seronegative for CMV, or the use of deglycerolised Frozen Red Blood Cells (RBCs) for transfusion in a seronegative preterm (<1200 g) child born to a mother with negative or unknown immune status regarding CMV infection [6]. These guidelines have helped to eliminate transfusion-induced CMV infection syndrome in preterm infants in the West. However, since the vast majority of blood donors in developing countries are seropositive for CMV, it would be imprudent to screen blood donors for CMV as very few seronegative blood units would be available for transfusion. Other preventive strategies (such as leukoreduction filtration, saline-washed RBCs, frozen deglycerolised RBCs, etc.,) are increasingly recommended to minimize transfusion transmission of CMV. These methods may be more appropriate and cost effective in developing countries for the prevention of CMV transmission through infected blood to immunosuppressed individuals. More studies are needed to elucidate the transmission of transfusion-associated CMV before proper guidelines on routine CMV screening in blood donors can be formulated [7].Like other developing countries Yemeni blood donors are screened only for HIV, Hepatitis B Virus (HBV), Hepatitis C Virus (HCV) and Syphilis. Also, there is no published data concerning CMV seroprevalence in blood donors in Yemen. Therefore the present study was undertaken to determine the prevalence of antibodies to CMV infection among male blood donors at the National Blood Transfusion and Research Center in Sana'a city, Yemen. It's a useful study for understanding situation of CMV infection in Yemen and offering the helpful data for government policymakers. Materials and MethodsA cross-sectional study was collected from 235 male healthy voluntary donors attending National Blood Transfusion and Research Center in Sana'a city, Yemen. About 5 ml blood samples was collected from each consenting subjects by venipuncture, transferred into sterile anticoag...

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Section: Resultscontrasting

confidence: 86%

Section: Resultsmentioning

confidence: 83%

mentioning

confidence: 99%

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Seroprevalence of Cytomegalovirus among Healthy Blood Donors in Sana'a City, Yemen

Al-Arnoot¹

2017

INID

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“…However, CMV is more common in developing countries and in people belonging to lower socio-economic status (Ojide et al, 2012;Arun et al, 2012). The seroprevalence of CMV is 80 -100% in Africa and Latin America (Souza et al, 2010). Like most other herpes viruses, CMV remains latent in the host after primary infection and persists for life in the organism.…”

Section: Introductionmentioning

confidence: 99%

The Prevalence of Cytomegalovirus among Eligible Blood Donors in Keffi, Nigeria

Pennap¹,

Joseph²,

Oti³

2016

Int.J.Curr.Microbiol.App.Sci

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“…The seroprevalence rates of CMV antibodies among blood donors show geographic differences, ranging from 45.8% in Germany to 96.5% in Brazil (3,7). Primary CMV infections in blood donors occur in all age groups, with prevalence rates between 0.2 and 1.2% (3,6,8,9).…”

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confidence: 99%

Systematic Evaluation of Different Nucleic Acid Amplification Assays for Cytomegalovirus Detection: Feasibility of Blood Donor Screening

2015

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Acute primary cytomegalovirus (CMV) infections, which commonly occur asymptomatically among blood donors, represent a significant risk for serious morbidity in immunocompromised patients (a major group of transfusion recipients). We implemented a routine CMV pool screening procedure for plasma for the identification of CMV DNA-positive donors, and we evaluated the sensitivities and performance of different CMV DNA amplification systems. Minipools (MPs) of samples from 18,405 individual donors (54,451 donations) were screened for CMV DNA using the RealStar CMV PCR assay (Altona Diagnostic Technologies), with a minimum detection limit of 11.14 IU/ml. DNA was extracted with a high-volume protocol (4.8 ml, Chemagic Viral 5K kit; PerkinElmer) for blood donor pool screening (MP-nucleic acid testing [NAT]) and with the Nuclisens easyMAG system (0. H uman cytomegalovirus (CMV) is a ubiquitous viral pathogen that causes mostly asymptomatic disease in immunocompetent individuals. In immunocompromised patients, however, CMV infection represents a significant risk for serious morbidity, e.g., due to interstitial pneumonia or hepatitis (1-3). Immunocompromised patients, such as patients undergoing hematopoietic stem cell transplantation (HSCT), solid-organ transplant recipients, infants with low birth weights, fetuses, pregnant woman, HIV patients, and patients being treated for hematological malignancies, belong to the major groups of transfusion recipients, and CMV-seronegative individuals were considered high-risk patients for transfusion-transmitted (TT)-CMV infections (4-6). The introduction of leukodepletion of blood products and provision of CMV-seronegative blood products reduced the incidence of TT-CMV infections in at-risk populations by 92%. However, TT-CMV breakthrough infections occur in 1 to 3% of high-risk patients who receive transfusions (4-6), possibly due to windowphase donations during acute primary CMV infections.The seroprevalence rates of CMV antibodies among blood donors show geographic differences, ranging from 45.8% in Germany to 96.5% in Brazil (3, 7). Primary CMV infections in blood donors occur in all age groups, with prevalence rates between 0.2 and 1.2% (3,6,8,9). The disease presentation is mostly asymptomatic, frequently with a prolonged course (10, 11). Mononucleosis-like symptoms are rare, whereas nonspecific viral disease symptoms occur often but not at significantly increased rates, compared to matched control groups (3,5).Determination of the prevalence of primary CMV infections among blood donors represents an important parameter for the effective prevention of 12). The aim of the present study was implementation of routine CMV DNA screening according to the setup used for our standard viral nucleic acid MATERIALS AND METHODSBlood donors. A total of 54,451 allogeneic blood donations from 18,405 individual German blood donors were routinely screened for the presence of CMV DNA by the Uni.Blutspendedienst OWL between March and June 2013. Master pools of 96 donations were set up by combin...

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Seroprevalence of cytomegalovirus antibodies in blood donors in southern, Brazil

Cited by 53 publications

References 4 publications

Seroprevalence of Cytomegalovirus among Healthy Blood Donors in Sana'a City, Yemen

Seroprevalence of Cytomegalovirus among Healthy Blood Donors in Sana'a City, Yemen

The Prevalence of Cytomegalovirus among Eligible Blood Donors in Keffi, Nigeria

Systematic Evaluation of Different Nucleic Acid Amplification Assays for Cytomegalovirus Detection: Feasibility of Blood Donor Screening

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