Seroprevalence of dengue IgG antibodies in symptomatic and asymptomatic individuals three years after an outbreak in Zhejiang Province, China

Luo, Shuang; Cui, Weihong; Li, Chan; Li, Feng; Fu, Tao; Liu, Qiyong; Ren, Jiangping; Sun, Jimin

doi:10.1186/s12879-018-3000-5

Cited by 22 publications

(22 citation statements)

References 25 publications

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“…In the present study, waning of antibody response was observed in 4.3% of children. A similar phenomenon has been observed in studies conducted in Taiwan and China [29, 30]. The study from China reported that the IgG prevalence was higher in symptomatic subjects compared to asymptomatic individuals [30].…”

Section: Discussionsupporting

confidence: 82%

“…A similar phenomenon has been observed in studies conducted in Taiwan and China [29, 30]. The study from China reported that the IgG prevalence was higher in symptomatic subjects compared to asymptomatic individuals [30]. It is also possible that the subjects with antibody response might be frequently exposed to the virus leading to a sustained response while those with waning of antibody response may not have encountered the virus after their initial exposure.…”

Section: Discussionsupporting

confidence: 72%

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Seroprevalence and incidence of primary dengue infections among children in a rural region of Maharashtra, Western India

Shah

Alagarasu

Karad³

et al. 2019

BMC Infect Dis

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Background Dengue infections have become a huge threat to public health systems in developing countries. Data on seroprevalence and incidence of dengue infections are lacking from rural regions of India. The objective of present study was to investigate the seroprevalence and incidence of dengue infection utilizing repeated serosurveys from a rural region of Maharashtra, Western India. Methods In the present study, 819 children between ages 5 to 15 years from 21 villages in Pune District of Maharashtra, India were sampled in 2014 and 2016. The sera were tested for the presence of dengue specific IgG using an indirect IgG ELISA kit. Results Overall seroprevalence of dengue was 15.3% (95% confidence intervals (CI) 12.9–17.8%) in 2014 and 20.5% (95% CI 17.8–23.4%) in 2016. Among the 694 children who were seronegative at baseline (2014), 78 seroconverted. Overall incidence rate of primary dengue was 54.2 infections/1000 children years (95% CI 43.0–67.3). Incidence of primary dengue infection was higher in children from urbanized villages compared to rural villages (Incidence rate ratio (IRR) 2.6 (95% CI 1.3–5.2)). In rural villages, incidence of primary dengue infection was higher in children aged 10 years or above as compared to those aged below 10 years (IRR 9.75 (95% CI 1.21–77.9). Conclusions The study provides the incidence rates of primary dengue infections from a rural region of India. More multi centric studies investigating the incidence of dengue will provide accurate estimate of incidence of dengue and help formulate well directed policies. The results also suggest that urbanization and transitions in demographic settings might favour dengue outbreaks in rural regions and these regions need to be targeted for vector control measures.

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Section: Discussionsupporting

confidence: 82%

Section: Discussionsupporting

confidence: 72%

Seroprevalence and incidence of primary dengue infections among children in a rural region of Maharashtra, Western India

Shah

Alagarasu

Karad³

et al. 2019

BMC Infect Dis

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“…Also in murine models, it has been reported that lethal antibody enhancement of dengue disease can be prevented by Fc modification 60 . More recently, severe dengue illness was explained by a substantial production of IgGs with enhanced affinity for the activating Fc receptor FcγRIIIA 61 , whilst another study found higher dengue IgG levels in symptomatic infections compared to asymptomatic ones 62 . Thus, the coefficients retrieved for IgG here might be an indication that children displaying increased IgG tires had high affinity IgGs.…”

Section: Discussionmentioning

confidence: 99%

Cross-serotype interactions and disease outcome prediction of dengue infections in Vietnam

Águas

Dorigatti

Coudeville

et al. 2019

Sci Rep

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Dengue pathogenesis is extremely complex. Dengue infections are thought to induce life-long immunity from homologous challenges as well as a multi-factorial heterologous risk enhancement. Here, we use the data collected from a prospective cohort study of dengue infections in schoolchildren in Vietnam to disentangle how serotype interactions modulate clinical disease risk in the year following serum collection. We use multinomial logistic regression to correlate the yearly neutralizing antibody measurements obtained with each infecting serotype in all dengue clinical cases collected over the course of 6 years (2004–2009). This allowed us to extrapolate a fully discretised matrix of serotype interactions, revealing clear signals of increased risk of clinical illness in individuals primed with a previous dengue infection. The sequences of infections which produced a higher risk of dengue fever upon secondary infection are: DEN1 followed by DEN2; DEN1 followed by DEN4; DEN2 followed by DEN3; and DEN4 followed by DEN3. We also used this longitudinal data to train a machine learning algorithm on antibody titre differences between consecutive years to unveil asymptomatic dengue infections and estimate asymptomatic infection to clinical case ratios over time, allowing for a better characterisation of the population’s past exposure to different serotypes.

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“…Administration is the weak link of urban integrated mosquito management in the city [42]. To combat mosquito-borne diseases [43,44] and to improve the quality of life of residents, we recommend that PHCS honestly reveals defects in urban mosquito management and seriously takes those exposed defects. The PHCS should strengthen PHC activities by strict adherence to NSC standards.…”

Section: Resultsmentioning

confidence: 99%

Urban mosquito management administration: Mosquito (Diptera: Culicidae) habitat surveillance and questionnaire survey in Wuhan, Central China

et al. 2020

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Background Creating National Sanitary City (CNSC) promotes appearance, environment sanitation and public health including vector management of cities in China. However, vector management especially mosquito management and the related administrative productivity of Patriotic Health Campaign System (PHCS) of National Sanitary Cities (NSCs) were questioned by many pest control professionals and citizens. In this study, we studied mosquito management of NSCs taking Wuhan as an example. The study aimed to (1) determine the distribution and abundance of immature mosquito habitats in built-up areas of Wuhan and (2) better understand the related administration procedure in CNSC. Methods Immature mosquito habitat surveillance was carried out in randomly selected premises of driving schools (DSs), schools or kindergartens (SKs), property management residential areas (PMRAs), construction sites (CSs), wide roads with storm drains (WRSDs) and urban creeks (UCs) in built-up areas of Wuhan from July to October 2015 followed by questionnaire interviews with one each of premise occupants and district departments responsible for mosquito management in these premises. Results Total of 64.1 km of route were inspected in 36 DSs, 36 SKs, 36 PMRAs, 36 CSs and 36 segments of WRSD and 2,158 potential mosquito habitats with 749 (35%) mosquito-positive habitats were found. The route index (RI) was 11.7, which was 14.6 times higher than the grade C criteria for vector density control (RI = 0.8 positive habitats/km) in CNSC. Occupants of 36 DSs, 36 SKs, 36 PMRAs, 34 CSs were interviewed and 77% of them reported no difference in mosquito infestation in their premises since 2013 and 80% of them knew about the responsibility and arrangements of PHCS of mosquito management in their

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Seroprevalence of dengue IgG antibodies in symptomatic and asymptomatic individuals three years after an outbreak in Zhejiang Province, China

Cited by 22 publications

References 25 publications

Seroprevalence and incidence of primary dengue infections among children in a rural region of Maharashtra, Western India

Seroprevalence and incidence of primary dengue infections among children in a rural region of Maharashtra, Western India

Cross-serotype interactions and disease outcome prediction of dengue infections in Vietnam

Urban mosquito management administration: Mosquito (Diptera: Culicidae) habitat surveillance and questionnaire survey in Wuhan, Central China

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