Seroprevalence of Dictyocaulus viviparus in first grazing season calves in Sweden

Höglund, Johan; Viring, S.; Törnqvist, Mats

doi:10.1016/j.vetpar.2004.07.018

Cited by 25 publications

(11 citation statements)

References 16 publications

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“…Infections with the cattle lungworm are common in cattle on pasture throughout the temperate regions of Europe [4], [9]–[12], [21]–[23]. The present study is the first to assess the distribution of dictyocaulosis in dairy farms all over Germany and, at the same time, the first providing information on geographical and epidemiological risk factors for the parasitosis.…”

Section: Discussionmentioning

confidence: 87%

“…However, in the 1990s an increase in the incidence of disease was recorded [1], [2] and coincidently there was a substantial increase in the proportion of second year grazing calves or adult cows [1], [3]. Both dairy and beef cattle can be affected [4], [5]. Outbreaks in dairy cattle herds can cause considerable economic losses due to reduced milk production, body weight and fertility or even death of infected animals on the one hand and expenses for laboratory diagnosis and treatments on the other hand [6]–[8].…”

Section: Introductionmentioning

confidence: 99%

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Lungworm Infections in German Dairy Cattle Herds — Seroprevalence and GIS-Supported Risk Factor Analysis

et al. 2013

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In November 2008, a total of 19,910 bulk tank milk (BTM) samples were obtained from dairy farms from all over Germany, corresponding to about 20% of all German dairy herds, and analysed for antibodies against the bovine lungworm Dictyocaulus viviparus by use of the recombinant MSP-ELISA. A total number of 3,397 (17.1%; n = 19,910) BTM samples tested seropositive. The prevalences in individual German federal states varied between 0.0% and 31.2% positive herds. A geospatial map was drawn to show the distribution of seropositive and seronegative herds per postal code area. ELISA results were further analysed for associations with land-use and climate data. Bivariate statistical analysis was used to identify potential spatial risk factors for dictyocaulosis. Statistically significant positive associations were found between lungworm seropositive herds and the proportion of water bodies and grassed area per postal code area. Variables that showed a statistically significant association with a positive BTM test were included in a logistic regression model, which was further refined by controlled stepwise selection of variables. The low Pseudo R2 values (0.08 for the full model and 0.06 for the final model) and further evaluation of the model by ROC analysis indicate that additional, unrecorded factors (e.g. management factors) or random effects may substantially contribute to lungworm infections in dairy cows. Veterinarians should include lungworms in the differential diagnosis of respiratory disease in dairy cattle, particularly those at pasture. Monitoring of herds through BTM screening for antibodies can help farmers and veterinarians plan and implement appropriate control measures.

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Section: Discussionmentioning

confidence: 87%

Section: Introductionmentioning

confidence: 99%

Lungworm Infections in German Dairy Cattle Herds — Seroprevalence and GIS-Supported Risk Factor Analysis

et al. 2013

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“…In a recent serological survey, we showed that 40% of the herds in Sweden were infected with D. viviparus (Höglund et al 2004b). We have also demonstrated that there is a high degree of genetic structure between isolates of D. viviparus in Sweden, based on both amplified fragment-length polymorphisms (AFLP) data and mtDNA sequences (Höglund et al 2006).…”

Section: Introductionmentioning

confidence: 83%

Limited sequence variation in the major sperm protein 1 (MSP) gene within populations and species of the genus Dictyocaulus (Nematoda)

et al. 2008

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Populations of the bovine lungworm, Dictyocaulus viviparus, are genetically structured based on variation in mtDNA and AFLP data. Our aim was to investigate if this genetic variability also is reflected in a protein recognized by the host immune system. We focused on the major sperm protein (MSP), a small and abundant protein used in diagnostic immunoassays, which has been shown to be variable in some nematodes but not others. MSP was sequenced using worm DNA from eight adult worms from each of nine populations whose genetic structure previously had been quantified. For comparison, we also analyzed MSP sequences of the closely related Dictyocaulus eckerti and Dictyocaulus capreolus and from nematodes with sequences deposited in GenBank. In contrast to previous results, this study shows that the MSP ofD. viviparus is similar to that of other nematodes. Almost no sequence variation, and thus no antigenic diversity, was detected in MSP between worms from different sub-populations or in the other Dictyocaulus species investigated. A functional test of a recombinant variant of the MSP showed that the expressed protein was recognized by antibodies in sera from infected cattle. This has practical implications for the development of species-specific markers, recombinant vaccines, and immunodiagnostics.

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“…The cattle lungworm, Dictyocaulus viviparus , is a parasitic nematode that can cause a severe pulmonary disease known as parasitic bronchitis. Dictyocaulus viviparus has a worldwide distribution, but is most common in areas with a temperate climate (reviewed in 1), and in a recent Swedish study 40% of farms were infected (2). The nematode has a direct life cycle, and cattle are infected when grazing herbage contaminated with third‐stage larvae (L 3 ) (1).…”

Section: Introductionmentioning

confidence: 99%

Mononuclear cell subsets in bronchoalveolar lavage fluid duringDictyocaulus viviparusinfection of calves: a potential role for γ/δ TCR‐expressing cells in airway immune responses?

Hagberg

Wattrang

Niskanen

et al. 2005

Parasite Immunology

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Mononuclear cell populations in the lungs of calves infected with Dictyocaulus viviparus were studied during primary infection and reinfection in order to identify cells involved in development of protective immunity to parasitic bronchitis. Three groups of calves were either inoculated with 500 third-stage larvae at both weeks 0 and 10 (n = 6), inoculated only at week 10 (n = 6), or remained uninfected (n = 3). The animals were monitored weekly by collection of bronchoalveolar lavage fluid (BALF), blood and faeces. Among mononuclear BALF-cell populations, the gamma/delta TCR-expressing cells showed a pronounced transient increase in proportion as well as in relative cell size 2 weeks post primary infection, whereas CD4-, CD8-, Ig- and CD14-expressing cells showed no significant differences related to the infection. The increase in gamma/delta TCR-expressing cells coincided with significantly increased proportions of eosinophils and recovery of adult worms in BALF. After reinfection, gamma/delta TCR-expressing cells increased again, but not until week 3 post inoculation, whereas eosinophils were increased by week 2 and reached higher levels than after primary infection. After reinfection, establishment of D. viviparus was less successful than after primary infection. In conclusion, these results indicate a role for gamma/delta TCR-expressing lymphocytes in the pathogenesis of D. viviparus infection.

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Seroprevalence of Dictyocaulus viviparus in first grazing season calves in Sweden

Cited by 25 publications

References 16 publications

Lungworm Infections in German Dairy Cattle Herds — Seroprevalence and GIS-Supported Risk Factor Analysis

Lungworm Infections in German Dairy Cattle Herds — Seroprevalence and GIS-Supported Risk Factor Analysis

Limited sequence variation in the major sperm protein 1 (MSP) gene within populations and species of the genus Dictyocaulus (Nematoda)

Mononuclear cell subsets in bronchoalveolar lavage fluid duringDictyocaulus viviparusinfection of calves: a potential role for γ/δ TCR‐expressing cells in airway immune responses?

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