Seroprevalence of Helicobacter pylori among Tunisian blood donors (outpatients), symptomatic patients and control subjects

Mansour, K. Ben; Keita, Abdelaye; Zribi, M.; Masmoudi, A.; Zarrouk, Sonia; Labbène, M.N.; Kallel, Lamia; Karoui, Sami; Fekih, M.; Matri, Samira; Boubaker, J.; Cheikh, Imed; Chouaïb, S.; Filali, Azza; Mami, N. Ben; Najjar, Taoufik; Fendri, C.

doi:10.1016/j.gcb.2009.06.015

Cited by 16 publications

(15 citation statements)

References 35 publications

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“…Although the prevalence of H. pylori antibodies in adults was similar to other studies, 26,27 it was surprising that there was an inverse association between anemia and H. pylori seroreactivity. This finding contrasts with previous studies that have reported a positive association.…”

Section: Discussionsupporting

confidence: 84%

Anemia and Helicobacter pylori Seroreactivity in a Rural Haitian Population

Shak¹,

Sodikoff²,

Speckman³

et al. 2011

The American Society of Tropical Medicine and Hygiene

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Anemia is a significant health concern worldwide and can be the result of nutritional, environmental, social, and infectious etiologies. We estimated the prevalence of anemia in 336 pre-school children and 132 adults in the rural Central Plateau of Haiti and assessed associations with age, sex, household size, water source, sanitation, and Helicobacter pylori seroreactivity using logistic regression analysis; 80.1% (269/336) of children and 63.6% (84/132) of adults were anemic. Among children, younger age was associated with increased prevalence of anemia (adjusted odds ratio [aOR] = 4.1, 95% confidence interval [CI] = 1.5–11.1 for children 6–11 months compared with children 48–59 months). Among adults, 50.8% were H. pylori-seropositive, and seropositivity was inversely associated with anemia (aOR = 0.4, 95% CI = 0.2–0.9). Anemia prevalence in this region of Haiti is very high and not attributable to sanitary conditions or a high prevalence of H. pylori infection.

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Section: Discussionsupporting

confidence: 84%

Anemia and Helicobacter pylori Seroreactivity in a Rural Haitian Population

Shak¹,

Sodikoff²,

Speckman³

et al. 2011

The American Society of Tropical Medicine and Hygiene

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Section: Discussionmentioning

confidence: 99%

“…In 2010, the result of a HPI serological prevalence study among Tunisian blood donors was 64% [12]. It was lower than in Peru where it was reported to be 75% in that same year, and also lower than in South Africa (84.2%) and the Ivory Coast (80–90%) [12]. Nevertheless, Tunisia has a low incidence of gastric cancer (6.6/100,000 inhabitants among males and 3.7/100,000 among females) according to the latest incidence study of 2004 [13].…”

Section: Discussionmentioning

confidence: 99%

Gastric Adenocarcinomas in Central Tunisia: Evolution Specificities through Two Decades and Relation with <b><i>Helicobacter pylori</i></b>

et al. 2018

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Introduction: In developed countries, authors have reported variations over time in the seat and histological type of gastric adenocarcinomas, which were explained by Helicobacter pylori infection (HPI) incidence changes. In North-African countries and the Arabic world, epidemiological changes in gastric adenocarcinomas are still unknown. Our study aims to explore and to describe those changes in central Tunisia. Materials and Methods: This is a retrospective observational and descriptive study including 876 cases based on the National Central Tunisian Register of Cancers over a period of 21 years. Two groups were formed and compared (group A: 337 patients from 1995 to 2005; group B: 539 patients from 2006 to 2015). Results: HPI decreased from 32.6% in group A to 11.2% in group B (p < 0.05). Signet ring cell carcinomas increased in 2 decades from 14% in group A to 36% in group B (p < 0.05). Proximal cancers were 16.61% in group A and increased to 19.66% in group B (p = 0.3). Total gastrectomy rate was 10.4% in group A versus 23.2% in group B (p < 0.05). Conclusion: This study has shown a significant increase of signet ring cell carcinomas with a simultaneous decrease in HPI in the last decade in central Tunisia.

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“…The literature search identified 17 studies reporting prevalence of H. pylori infection in various groups of healthy subjects [1–17]. Characteristics of these studies are provided in Table 1.…”

Section: Prevalencementioning

confidence: 99%

“…Characteristics of these studies are provided in Table 1. Seven studies used stool antigen testing [3,5,7–9,15,16], five used serologic testing [2,4,10–12], three used carbon 13 urea breath testing [1,6,13], one used both stool antigen testing and serology in all included individuals [14], and one used stool antigen testing in some participants and histologic examination of gastric biopsy specimens in others [17]. Prevalence of infection with H. pylori varied between 7% in a study conducted among asymptomatic children in the Czech Republic [15], and 87% in a South African population from the Eastern Cape province [7].…”

Section: Prevalencementioning

confidence: 99%

Epidemiology of Helicobacter pylori infection and Public Health Implications

2010

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This article summarizes the published literature concerning the epidemiology and public health implications of Helicobacter pylori infection published from April 2009 through March 2010. Prevalence of infection varied between 7 and 87% and was lower in European studies. All retrieved studies examining transmission of infection concluded that spread is from person‐to‐person. One study collecting stool and vomitus samples from patients with acute gastroenteritis detected H. pylori DNA in 88% of vomitus and 74% of stool samples. Proposed risk factors for infection included male gender, increasing age, shorter height, tobacco use, lower socioeconomic status, obesity, and lower educational status of the parents in studies conducted among children. Decision analysis models suggest preventing acquisition of H. pylori, via vaccination in childhood, could be cost‐effective and may reduce incidence of gastric cancer by over 40%. As yet, no country has adopted public health measures to treat infected individuals or prevent infection in populations at risk.

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Seroprevalence of Helicobacter pylori among Tunisian blood donors (outpatients), symptomatic patients and control subjects

Cited by 16 publications

References 35 publications

Anemia and Helicobacter pylori Seroreactivity in a Rural Haitian Population

Anemia and Helicobacter pylori Seroreactivity in a Rural Haitian Population

Gastric Adenocarcinomas in Central Tunisia: Evolution Specificities through Two Decades and Relation with <b><i>Helicobacter pylori</i></b>

Epidemiology of Helicobacter pylori infection and Public Health Implications

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