Seroprevalence of Helicobacter pylori immunoglobulin G antibodies in South African mothers and their children

Mosane, Tshepo W; Malope, Babatyi I; Ratshikhopha, Muofhe Edith; Hiss, Donavon C; Sitas, Freddy

doi:10.1097/00042737-200401000-00017

Cited by 8 publications

(5 citation statements)

References 5 publications

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“…Available data at the time of planning the study indicated that the prevalence of H. pylori infection was 74% in patients with dyspepsia referred for endoscopy in Uganda [7] and ranged from 70% to 100% in adults in Africa [24, 25]. A sample size of 322 women would be needed to estimate a prevalence of 70% with a confidence level of 95% and a precision of 5% [26].…”

Section: Methodsmentioning

confidence: 99%

Helicobacter pylori infection in pregnant women in four districts of Uganda: role of geographic location, education and water sources

2014

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Background: The prevalence of Helicobacter pylori infection varies in relation to geography, ethnicity and socioeconomic factors. Available data on the prevalence of Helicobacter pylori infection in Uganda are not representative of the general population. We sought to describe the epidemiology of this infection in pregnant women in Uganda to provide background data for a study into the effect of H. pylori infection during pregnancy on the hematological response to iron supplementation. Methods: Using a cross-sectional design, H. pylori infection was assessed by the stool antigen test among 447 pregnant women attending antenatal care clinics in Apac, Mbale, Mbarara and Rakai Districts which are in different geographical regions in Uganda, and at Kawempe Health Center which serves a low-income densely populated area in Kampala City. Socio-demographic and household data were collected by face-to-face interviews using a questionnaire. Associations between H. pylori infection and socio-demographic and household characteristics were analyzed using logistic regression. Results: The overall prevalence of H. pylori infection was 45.2% but varied by geographical location from 18.2% in Apac District to 60.5% at Kawempe Health Centre. At 18.4%, the Langi ethnic group, who were enrolled exclusively in Apac District, had the lowest prevalence of H. pylori infection while the Gisu had the highest prevalence (58.4%). H. pylori was independently associated with enrollment at clinics not in Apac (adjusted OR = 5.68; 95% CI: 3.02-10.7) and with using water from public wells, boreholes or springs (AOR = 3.20; 95% CI: 1.19-8.61) and from rivers, lakes or streams (AOR = 5.20; 95% CI: 1.58-17.05). Urban residence (AOR = 1.71; 95% CI: 1.13-2.60) and no formal education (AOR = 1.95; 95% CI: 1.03-3.67) were also independently associated with H. pylori infection. Conclusions:The unexpected variation in the prevalence of H. pylori infection in Uganda calls for population-based studies in the region and offers an opportunity to study the transmission dynamics of H. pylori infection. The association between H. pylori infection and surface water sources for household use suggests waterborne transmission of H. pylori infection highlighting the need for concerted efforts in environmental health in communities and at the household level.

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Section: Methodsmentioning

confidence: 99%

Helicobacter pylori infection in pregnant women in four districts of Uganda: role of geographic location, education and water sources

2014

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“…14 H. pylori infection seems to be common in South Africa, as might be expected in developing countries. 15,16 Although studies have reported the prevalence of the organism in the country, most adopted a sero-prevalence approach, which does not provide more information other than the presence of antibodies, which are poor markers of active infection. In Cape Town, a prevalence of 63% of the pathogen in NUD patients based on histology reports was documented, 13 and a prevalence of 81% in NUD patients based on serology testing.…”

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confidence: 99%

Helicobacter pylori prevalence in dyspeptic patients in the Eastern Cape province - race and disease status

et al. 2010

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“…Childhood acquisition is common with more than 50% of all children in South Africa being infected by the age of 10 years, with prevalence rising to 80% in adults (Kidd et al, 1999a). Pelsar et al (1997) documented a high prevalence (67 -84%) of H. pylori antibodies in children in Bloemfontein, while Mosane et al (2004) also reported H. pylori IgG antibodies in South African mothers and their children. In another study, Samie et al (2007) described a prevalence of 50.6% among children <5 years old in their study in Thohoyandou, North of South Africa.…”

Section: Prevalence Of Helicobacter Pylorimentioning

confidence: 99%

“…This apparent anomality has been termed the 'African enigma' (Holcombe, 1992;Kidd et al, 1999a;Ahmed et al, 2007). H. pylori infection is common in South Africa, as might be expected in developing countries (Pelser et al, 1997;Mosane et al, 2004). Reports on prevalence of the organism in the country are mostly derived from seroprevalence data (Kidd et al, 1999a;O'keefe et al, 2000), which does not provide more information other than the presence of antibodies, which are poor mar-kers of active infection.…”

Section: Introductionmentioning

confidence: 99%

A South African perspective on Helicobacter pylori: Prevalence, epidemiology and antimicrobial chemotherapy

Nicoline¹,

Rol²,

Ndip³

2013

Afr. J. Microbiol. Res.

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The spiral shaped Gram-negative bacterium, Helicobacter pylori colonizes the stomach of more than 50% of the world's population and can persist for a lifetime if not completely eradicated. High prevalence of the bacterium is common in most population although a majority of the infected patients remain asymptomatic; with only a small subset of infected people experiencing H. pylori-associated illnesses such as chronic gastritis, gastric and duodenal ulcers, mucosa associated lymphoid tissue lymphoma as well as adenocarcinoma. H. pylori is common in South Africa with prevalence ranging from 50 -84% as depicted in the various studies conducted across the country. Infection is usually acquired in childhood and is associated with low socio-economic status, overcrowding, poor sanitation and unclean water supplies which appear to influence the rate of transmission. Eradication of this pathogen is a global challenge due to its alarming rate of drug resistance. Triple therapy consisting of a proton pump inhibitor and clarithromycin and either metronidazole or amoxicillin, is recommended for treatment. In this article, we review the major studies conducted based on H. pylori prevalence, epidemiology and antimicrobial chemotherapy in South Africa. Overall, the results of the findings indicate a high prevalence of H. pylori, resistance to recommended therapy and identified the need to consider natural products, including medicinal plants and honey as leads, which may offer useful alternatives in the treatment of H. pylori-related infections in South Africa and the world at large.

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Seroprevalence of Helicobacter pylori immunoglobulin G antibodies in South African mothers and their children

Cited by 8 publications

References 5 publications

Helicobacter pylori infection in pregnant women in four districts of Uganda: role of geographic location, education and water sources

Helicobacter pylori infection in pregnant women in four districts of Uganda: role of geographic location, education and water sources

Helicobacter pylori prevalence in dyspeptic patients in the Eastern Cape province - race and disease status

A South African perspective on Helicobacter pylori: Prevalence, epidemiology and antimicrobial chemotherapy

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